Gene/Proteome Database (LMPD)

LMPD ID
LMP008309
Gene ID
180441
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SEL-12
Gene Symbol
sel-12
Synonyms
CELE_F35H12.3
Alternate Names
Protein SEL-12
Chromosome
X

Proteins

Protein SEL-12
Refseq ID NP_508175
Protein GI 17569443
UniProt ID P52166
mRNA ID NM_075774
Length 444
RefSeq Status REVIEWED
MPSTRRQQEGGGADAETHTVYGTNLITNRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVFTMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLIHGWLIVSSFLLLFLFTTIYVQEVLKSFDVSPSALLVLFGLGNYGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREPTSSDSNTSTAFPGEASCSSETPKRPKVKRIPQKVQIESNTTASTTQNSGVRVERELAAERPTVQDANFHRHEEEERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTLVLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQKCLLY

Gene Information

Entrez Gene ID
180441
Gene Name
Protein SEL-12
Gene Symbol
sel-12
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0030018 IBA:RefGenome C Z disc
GO:0016324 IBA:RefGenome C apical plasma membrane
GO:0030424 IBA:RefGenome C axon
GO:0005938 IBA:RefGenome C cell cortex
GO:0009986 IBA:RefGenome C cell surface
GO:0035253 IBA:RefGenome C ciliary rootlet
GO:0043198 IBA:RefGenome C dendritic shaft
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0030426 IBA:RefGenome C growth cone
GO:0005887 IBA:RefGenome C integral component of plasma membrane
GO:0005765 IBA:RefGenome C lysosomal membrane
GO:0045121 IBA:RefGenome C membrane raft
GO:0005743 IBA:RefGenome C mitochondrial inner membrane
GO:0031594 IBA:RefGenome C neuromuscular junction
GO:0043025 IBA:RefGenome C neuronal cell body
GO:0005634 IBA:RefGenome C nucleus
GO:0048471 IDA:WormBase C perinuclear region of cytoplasm
GO:0004190 IEA:InterPro F aspartic-type endopeptidase activity
GO:0004175 IBA:RefGenome F endopeptidase activity
GO:0007220 IBA:RefGenome P Notch receptor processing
GO:0007219 NAS:UniProtKB P Notch signaling pathway
GO:0042987 IBA:RefGenome P amyloid precursor protein catabolic process
GO:0045176 IDA:WormBase P apical protein localization
GO:0050435 IBA:RefGenome P beta-amyloid metabolic process
GO:0006816 IBA:RefGenome P calcium ion transport
GO:0001708 IMP:WormBase P cell fate specification
GO:0016048 IMP:UniProtKB P detection of temperature stimulus
GO:0006509 IBA:RefGenome P membrane protein ectodomain proteolysis
GO:0043066 IBA:RefGenome P negative regulation of apoptotic process
GO:0007399 IMP:UniProtKB P nervous system development
GO:0018991 IMP:WormBase P oviposition
GO:0045747 IGI:WormBase P positive regulation of Notch signaling pathway
GO:0048563 IMP:WormBase P post-embryonic organ morphogenesis
GO:0017015 IGI:WormBase P regulation of transforming growth factor beta receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
cel04330 Notch signaling pathway
ko04330 Notch signaling pathway
cel04310 Wnt signaling pathway
ko04310 Wnt signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001108 Peptidase A22A, presenilin
IPR001686 Peptidase A22A, presenilin, nematode type
IPR006639 Presenilin/signal peptide peptidase

UniProt Annotations

Entry Information

Gene Name
Protein SEL-12
Protein Entry
PSN_CAEEL
UniProt ID
P52166
Species
C. elegans

Comments

Comment Type Description
Developmental Stage Expressed both maternally and zygotically. Ubiquitously expressed throughout the development and in the adult. {ECO:0000269|PubMed:12668626}.
Domain The PAL motif is required for normal active site conformation. {ECO:0000250}.
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. {ECO:0000269|PubMed:10917532, ECO:0000269|PubMed:12413907}.
Sequence Caution Sequence=AAA85511.1; Type=Frameshift; Positions=413; Evidence={ECO:0000305};
Similarity Belongs to the peptidase A22A family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Subunit Homodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable). {ECO:0000305}.
Tissue Specificity Expressed in most neurons. {ECO:0000269|PubMed:10917532}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008309 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17569443 RefSeq NP_508175 444 Protein SEL-12

Identical Sequences to LMP008309 proteins

Reference Database Accession Length Protein Name
GI:17569443 EMBL CCD70617.1 444 Protein SEL-12 [Caenorhabditis elegans]
GI:17569443 GenBank AAD50991.1 444 presenilin SEL-12 [Caenorhabditis elegans]
GI:17569443 SwissProt P52166.2 444 RecName: Full=Presenilin sel-12; AltName: Full=Suppressor/enhancer of lin-12 protein 12 [Caenorhabditis elegans]

Related Sequences to LMP008309 proteins

Reference Database Accession Length Protein Name
GI:17569443 GenBank AAA85511.1 461 membrane protein [Caenorhabditis elegans]
GI:17569443 GenBank AAO00636.1 445 Sequence 5 from patent US 6489459
GI:17569443 GenBank ABC05316.1 461 Sequence 6 from patent US 6958320
GI:17569443 PIR - 461 sel-12 protein - Caenorhabditis elegans [Caenorhabditis elegans]
GI:17569443 PIR - 836 protein F35H12.3 [imported] - Caenorhabditis elegans [Caenorhabditis elegans]
GI:17569443 PRF - 461 membrane protein sel-12 [Caenorhabditis elegans]