Gene/Proteome Database (LMPD)

LMPD ID
LMP008708
Gene ID
180992
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SUR-5
Gene Symbol
sur-5
Synonyms
CELE_K03A1.5
Alternate Names
Protein SUR-5
Chromosome
X
EC Number
6.2.1.16

Proteins

Protein SUR-5
Refseq ID NP_509229
Protein GI 17569507
UniProt ID Q21166
mRNA ID NM_076828
Length 700
RefSeq Status REVIEWED
MTAVSANGKTTEKHENGAHTNGTTNGTTNGSMNGNEISHVQKLQPVYYKPPQNLETFELSLRNHFEEKTNKKFADYREFHRFTCDNYGIFWEDLLKLSDVKLHQNYNQVIDHNLKINERPRWFNGATLNYTENVIERGTATDIAVLNASIEETVTEYTYDNLRKDVYRIATSLRNYGIGPGDTVCGFVPNTYDTLVAVFATAAVGAAWCSASVDFGPAGVLDRFRQVHPKVLFTVNHVTYKKKLIDQTDKINEIVKELPTLEKIVVSDTFTSVKFDATKYNQSDKFSSLEEFKTPIADVVLPFVYTPVPFSDPLFVMFSSGTTGIPKAMVHTVGGTLLKHIEEHLVQGDSKKHDRMFFYTTCGWMMYNWMISFLYSKGSVVLFDECPLAPDTHIIMKIAAKTQSTMIGMGAKLYDEYLRLQIPFNTLYDLSKIHTVYSTGSPLKKECFAYINTYIAPGALIASISGGTDIIGCFVGGIKSLSITPGECQCLFLGMDIKSFNYMDEEIINSDEQGELVCVTPFPSMPSHFLNDTDGKKYRDAYFARLEPFWAHGDFVRVNHSTGGVEMLGRSDATLNRGGVRIGTAEIYSVVEKIPHIADCIVAGRLVEEGMDEEVLLFVKMVPGQELTHSIQAAIVSKLRNDMSPRHVPNKIYAVDDIPYTSSGKKVEVAVKQIVSGKAVQKASSIRNPESLDHFVQYRL

Gene Information

Entrez Gene ID
180992
Gene Name
Protein SUR-5
Gene Symbol
sur-5
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0030729 IEA:UniProtKB-EC F acetoacetate-CoA ligase activity
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
cel00650 Butanoate metabolism
ko00650 Butanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR005914 Acetoacetyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
Protein SUR-5
Protein Entry
SUR5_CAEEL
UniProt ID
Q21166
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
Function Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. {ECO:0000250, ECO:0000269|PubMed:9671465}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9671465}. Nucleus {ECO:0000269|PubMed:9671465}.
Tissue Specificity Present in most cells of the organism. {ECO:0000269|PubMed:9671465}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008708 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17569507 RefSeq NP_509229 700 Protein SUR-5

Identical Sequences to LMP008708 proteins

Reference Database Accession Length Protein Name
GI:17569507 EMBL CCD72541.1 700 Protein SUR-5 [Caenorhabditis elegans]
GI:17569507 GenBank AAE69079.1 700 Sequence 4 from patent US 6225456
GI:17569507 GenBank AAM44123.1 700 SUR-5 [Caenorhabditis elegans]
GI:17569507 GenBank ABZ32883.1 700 Sequence 6821 from patent US 7314974
GI:17569507 SwissProt Q21166.1 700 RecName: Full=Acetoacetyl-CoA synthetase; AltName: Full=Suppressor of activated let-60 Ras protein 5 [Caenorhabditis elegans]

Related Sequences to LMP008708 proteins

Reference Database Accession Length Protein Name
GI:17569507 EMBL CAP30256.1 691 Protein CBR-SUR-5 [Caenorhabditis briggsae]
GI:17569507 GenBank EFO82746.1 692 CRE-SUR-5 protein [Caenorhabditis remanei]
GI:17569507 GenBank ADY43053.1 662 Acetoacetyl-CoA synthetase [Ascaris suum]
GI:17569507 GenBank EGT53033.1 764 hypothetical protein CAEBREN_30458 [Caenorhabditis brenneri]
GI:17569507 RefSeq XP_002645018.1 691 C. briggsae CBR-SUR-5 protein [Caenorhabditis briggsae]
GI:17569507 RefSeq XP_003118148.1 692 CRE-SUR-5 protein [Caenorhabditis remanei]