Gene/Proteome Database (LMPD)

LMPD ID
LMP008863
Gene ID
36390
Species
Drosophila melanogaster (Drosophila)
Gene Name
Imitation SWI
Gene Symbol
Iswi
Synonyms
ACF; anon-EP1279744.124; CG8625; CHRAC; dCHRAC; dISWI; Dmel\CG8625; dNURF; ISW; iswi; ISWI; NURF; NURF 140; Nurf-140; NURF-140; p140; p140/ISWI; SWI
Alternate Names
CG8625-PA; CG8625-PB; CG8625-PC; ISWI; ISWI ATPase; Iswi-PA; Iswi-PB; Iswi-PC; imitation SW; imitation SWI; imitation switch; imitation-SWI; nucleosome remodeling factor; nucleosome remodeling factor - 140kD
Chromosome
2R
Map Location
49B10-49B10
EC Number
3.6.4.-

Proteins

imitation SWI, isoform A
Refseq ID NP_523719
Protein GI 17737463
UniProt ID Q24368
mRNA ID NM_078995
Length 1027
RefSeq Status REVIEWED
MSKTDTAAVEATEENSNETTSDAATSSSGEKEAEFDNKIEADRSRRFDFLLKQTEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEKDVADHRHRKTEQEEDEELLAEDSATKEIFRFDASPAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHIVIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFKKFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSEDFDEWFNTNTCLGDDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQRDWYTKVLLKDIDVVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDTHLVYNSGKMAILDKLLPKLQEQGSRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDKMVIQGGRLVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDEDIDVILERGEAKTAEQKAALDSLGESSLRTFTMDTNGEAGTSSVYQFEGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYYFRKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPLTEEEIQEKENLLSQGFTAWTKRDFNQFIKANEKYGRDDIDNIAKDVEGKTPEEVIEYNAVFWERCTELQDIERIMGQIERGEGKIQRRLSIKKALDQKMSRYRAPFHQLRLQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAIRASPQFRFDWFIKSRTALELQRRCNTLITLIERENIELEEKERAEKKKKAPKGSVSAGSGSASSNTPAPAPQPKASQKRKSEVVATSSNSKKKKK
imitation SWI, isoform B
Refseq ID NP_725203
Protein GI 24653132
UniProt ID Q24368
mRNA ID NM_165930
Length 1027
RefSeq Status REVIEWED
Protein sequence is identical to GI:17737463 (mRNA isoform)
imitation SWI, isoform C
Refseq ID NP_725204
Protein GI 24653134
UniProt ID Q24368
mRNA ID NM_165931
Length 1027
RefSeq Status REVIEWED
Protein sequence is identical to GI:17737463 (mRNA isoform)

Gene Information

Entrez Gene ID
36390
Gene Name
Imitation SWI
Gene Symbol
Iswi
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016590 IDA:FlyBase C ACF complex
GO:0008623 IDA:FlyBase C CHRAC
GO:0016589 IDA:FlyBase C NURF complex
GO:0031213 IPI:FlyBase C RSF complex
GO:0005634 IDA:FlyBase C nucleus
GO:0005700 IDA:FlyBase C polytene chromosome
GO:0005667 IPI:FlyBase C transcription factor complex
GO:0005524 ISS:FlyBase F ATP binding
GO:0003677 IEA:InterPro F DNA binding
GO:0003678 TAS:FlyBase F DNA helicase activity
GO:0008094 IDA:FlyBase F DNA-dependent ATPase activity
GO:0003682 IEA:InterPro F chromatin binding
GO:0070615 IDA:FlyBase F nucleosome-dependent ATPase activity
GO:0000166 TAS:FlyBase F nucleotide binding
GO:0008134 IPI:FlyBase F transcription factor binding
GO:0006200 IDA:GOC P ATP catabolic process
GO:0043044 IEA:InterPro P ATP-dependent chromatin remodeling
GO:0032508 TAS:GOC P DNA duplex unwinding
GO:0006333 IDA:FlyBase P chromatin assembly or disassembly
GO:0006325 IMP:FlyBase P chromatin organization
GO:0006338 ISS:FlyBase P chromatin remodeling
GO:0048813 IMP:FlyBase P dendrite morphogenesis
GO:0035076 IGI:FlyBase P ecdysone receptor-mediated signaling pathway
GO:0007517 IMP:FlyBase P muscle organ development
GO:0045892 IMP:FlyBase P negative regulation of transcription, DNA-templated
GO:0035063 IMP:FlyBase P nuclear speck organization
GO:0006334 IDA:FlyBase P nucleosome assembly
GO:0042766 IDA:FlyBase P nucleosome mobilization
GO:0016584 IDA:FlyBase P nucleosome positioning
GO:0045944 IMP:FlyBase P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 TAS:FlyBase P positive regulation of transcription, DNA-templated
GO:0042752 IMP:FlyBase P regulation of circadian rhythm
GO:0006357 IMP:FlyBase P regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:FlyBase P regulation of transcription, DNA-templated
GO:0006351 IDA:FlyBase P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR020838 DBINO domain
IPR014001 Helicase superfamily 1/2, ATP-binding domain
IPR001650 Helicase, C-terminal
IPR009057 Homeodomain-like
IPR015194 ISWI, HAND domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR017884 SANT domain
IPR001005 SANT/Myb domain
IPR015195 SLIDE domain
IPR000330 SNF2-related

UniProt Annotations

Entry Information

Gene Name
Imitation SWI
Protein Entry
ISWI_DROME
UniProt ID
Q24368
Species
Drosophila

Comments

Comment Type Description
Developmental Stage Present throughout embryonic, larval and pupal development and in female adults. Present at low levels in adult males (at protein level). {ECO:0000269|PubMed:8521502}.
Function Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. {ECO:0000269|PubMed:12502740, ECO:0000269|PubMed:16264191, ECO:0000269|PubMed:8521501, ECO:0000269|PubMed:8521502}.
Interaction P18824:arm; NbExp=2; IntAct=EBI-367628, EBI-216128;
Similarity Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. {ECO:0000305}.
Similarity Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00541}.
Similarity Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00542}.
Similarity Contains 2 SANT domains. {ECO:0000255|PROSITE- ProRule:PRU00624}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00624, ECO:0000269|PubMed:8521502}.
Subunit Component of the NURF complex composed of Caf1, E(bx), Nurf-38 and Iswi. {ECO:0000269|PubMed:8521502}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008863 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17737463 RefSeq NP_523719 1027 imitation SWI, isoform A

Identical Sequences to LMP008863 proteins

Reference Database Accession Length Protein Name
GI:17737463 GenBank ACI15757.1 1027 FI04427p [Drosophila melanogaster]
GI:17737463 gnl FlyBase 1027 imitation SWI, isoform A [Drosophila melanogaster]
GI:17737463 gnl FlyBase 1027 imitation SWI, isoform B [Drosophila melanogaster]
GI:17737463 gnl FlyBase 1027 imitation SWI, isoform C [Drosophila melanogaster]
GI:17737463 RefSeq NP_725203.1 1027 imitation SWI, isoform B [Drosophila melanogaster]
GI:17737463 RefSeq NP_725204.1 1027 imitation SWI, isoform C [Drosophila melanogaster]

Related Sequences to LMP008863 proteins

Reference Database Accession Length Protein Name
GI:17737463 GenBank AAM11261.1 1027 RH13158p [Drosophila melanogaster]
GI:17737463 GenBank EDW47607.1 1027 GM21414 [Drosophila sechellia]
GI:17737463 GenBank EDW90729.1 1027 GE12485 [Drosophila yakuba]
GI:17737463 RefSeq XP_001975876.1 1027 GG20326 [Drosophila erecta]
GI:17737463 RefSeq XP_002033594.1 1027 GM21414 [Drosophila sechellia]
GI:17737463 RefSeq XP_002091017.1 1027 GE12485 [Drosophila yakuba]