Gene/Proteome Database (LMPD)

LMPD ID
LMP009072
Gene ID
40404
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG14577 gene product from transcript CG14577-RA
Gene Symbol
ORMDL
Synonyms
CG14577; Dmel\CG14577
Alternate Names
CG14577-PA; ORMDL; ORMDL-PA
Chromosome
3L
Map Location
78E1-78E1

Proteins

ORMDL
Refseq ID NP_730669
Protein GI 24668274
UniProt ID Q9VP04
mRNA ID NM_168929
Length 154
RefSeq Status REVIEWED
MTSIAGGHGEANPNSSWLSARGFWLAYLLGLLSVHLLFLSVPFVSIPWAWTATNLLHNAAHLYFLHVIKGAPWLSTENDPSRRWTHWEQIDDGVQMTTTRKFLTAVPIVLFLLTCLYTRNNTEHFIPNFISLVVVTLPKLPQFHGVRLFNINKY

Gene Information

Entrez Gene ID
40404
Gene Name
CG14577 gene product from transcript CG14577-RA
Gene Symbol
ORMDL
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:UniProtKB C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane

Domain Information

InterPro Annotations

Accession Description
IPR007203 ORMDL family

UniProt Annotations

Entry Information

Gene Name
CG14577 gene product from transcript CG14577-RA
Protein Entry
ORMDL_DROME
UniProt ID
Q9VP04
Species
Drosophila

Comments

Comment Type Description
Function Negative regulator of sphingolipid synthesis. {ECO:0000250}.
Interaction Q960E8:Tfb1; NbExp=1; IntAct=EBI-153636, EBI-104674;
Similarity Belongs to the ORM family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Ubiquitously and homogeneously expressed in the syncytial blastoderm and during the cellularization stage. In stages 11-12, it is expressed in the germ-band layer In later stages (stage 14), it is mainly detected in the ectodermal tissues. In imaginal disks of third-instar larvae, it is uniformly and homogeneously expressed in eye-antenna, leg, wing and haltere imaginal disks, which is consistent with the former ectodermal expression detected in latestage embryos. {ECO:0000269|PubMed:12093374}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009072 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24668274 RefSeq NP_730669 154 ORMDL

Identical Sequences to LMP009072 proteins

Reference Database Accession Length Protein Name
GI:24668274 GenBank AAY55780.1 154 IP01962p [Drosophila melanogaster]
GI:24668274 GenBank ABK56983.1 154 IP01963p [Drosophila melanogaster]
GI:24668274 GenBank ACL88154.1 154 ORMDL-PA, partial [synthetic construct]
GI:24668274 GenBank ACL92490.1 154 ORMDL-PA [synthetic construct]
GI:24668274 gnl FlyBase 154 ORMDL [Drosophila melanogaster]
GI:24668274 SwissProt Q9VP04.1 154 RecName: Full=ORM1-like protein; AltName: Full=dORMDL [Drosophila melanogaster]

Related Sequences to LMP009072 proteins

Reference Database Accession Length Protein Name
GI:24668274 GenBank AAU51230.1 158 Sequence 32175 from patent US 6703491
GI:24668274 GenBank AAU66447.1 158 Sequence 47392 from patent US 6703491
GI:24668274 GenBank EDW44397.1 154 GM22391 [Drosophila sechellia]
GI:24668274 GenBank EDX11416.1 154 GD14981 [Drosophila simulans]
GI:24668274 RefSeq XP_002040844.1 154 GM22391 [Drosophila sechellia]
GI:24668274 RefSeq XP_002085831.1 154 GD14981 [Drosophila simulans]