Gene/Proteome Database (LMPD)

LMPD ID
LMP009799
Gene ID
827864
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ADP-ribosylation factor GTPase-activating protein AGD12
Gene Symbol
ZAC
Synonyms
AGD12; ARF-GAP domain 12; ZAC
Alternate Names
ADP-ribosylation factor GTPase-activating protein AGD12
Chromosome
4
Summary
ADP-ribosylation factor GTPase-activating protein containing zinc finger and C2 domains and a novel PI-3-P-binding protein region. Binds PI-3-P. Highest expression levels in flowering tissue, rosettes and roots. A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes.
Orthologs
View orthologs and multiple alignments for ZAC

Proteins

ADP-ribosylation factor GTPase-activating protein AGD12
Refseq ID NP_567620
Protein GI 18415638
UniProt ID Q9FVJ3
mRNA ID NM_118235
Length 337
RefSeq Status REVIEWED
MSYSGAGLGKPGSGKRRIRDLLTQSDNRVCADCGAPDPKWASANIGVFICLKCCGVHRSLGSHISKVLSVTLDEWSDEEVDSMIEIGGNASANSIYEAFIPEGSSKPGPDASHDQRMRFIRSKYEHQEFLKPSLRITSVRGSSTKTPAFLSSSLSKKIVDSFRTNSSSQQPQLEGMVEFIGLLKVTIKKGTNMAIRDMMSSDPYVVLTLGQQKAQSTVVKSNLNPVWNEELMLSVPHNYGSVKLQVFDYDTFSADDIMGEAEIDIQPLITSAMAFGDPEMFGDMQIGKWLKSHDNALIEDSIINIADGKVKQEVQIKLQNVESGELELEMEWLPLEQ
ADP-ribosylation factor GTPase-activating protein AGD12
Refseq ID NP_974581
Protein GI 42572969
UniProt ID Q9FVJ3
mRNA ID NM_202852
Length 337
RefSeq Status REVIEWED
Protein sequence is identical to GI:18415638 (mRNA isoform)
ADP-ribosylation factor GTPase-activating protein AGD12
Refseq ID NP_974582
Protein GI 42572971
UniProt ID Q9FVJ3
mRNA ID NM_202853
Length 337
RefSeq Status REVIEWED
Protein sequence is identical to GI:18415638 (mRNA isoform)
ADP-ribosylation factor GTPase-activating protein AGD12
Refseq ID NP_849416
Protein GI 30685338
UniProt ID Q9FVJ3
mRNA ID NM_179085
Length 337
RefSeq Status REVIEWED
Protein sequence is identical to GI:18415638 (mRNA isoform)

Gene Information

Entrez Gene ID
827864
Gene Name
ADP-ribosylation factor GTPase-activating protein AGD12
Gene Symbol
ZAC
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:TAIR C Golgi apparatus
GO:0005886 IDA:TAIR C plasma membrane
GO:0005773 IDA:TAIR C vacuole
GO:0008060 IDA:TAIR F ARF GTPase activator activity
GO:0005543 IDA:TAIR F phospholipid binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006886 TAS:TAIR P intracellular protein transport
GO:0043547 IDA:GOC P positive regulation of GTPase activity
GO:0032312 IEA:InterPro P regulation of ARF GTPase activity

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ko04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR001164 Arf GTPase activating protein
IPR000008 C2 domain

UniProt Annotations

Entry Information

Gene Name
ADP-ribosylation factor GTPase-activating protein AGD12
Protein Entry
AGD12_ARATH
UniProt ID
Q9FVJ3
Species
Arabidopsis

Comments

Comment Type Description
Domain The C2 domain binds anionic phospholipids promiscuously in the presence of calcium while the N-terminal region (1-174) show a specific affinity for phosphatidylinositol 3-monophosohate.
Function GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Binds phosphatidylinositol 3-monophosohate (PI-3-P) and anionic phospholipids.
Sequence Caution Sequence=CAA17535.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB79116.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Contains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular Location Golgi apparatus {ECO:0000269|PubMed:11202441}. Cell membrane {ECO:0000269|PubMed:11202441}.
Tissue Specificity Expressed in roots, leaves, flowers and siliques. Low levels of expression in seeds and stems. {ECO:0000269|PubMed:11202441}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009799 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18415638 RefSeq NP_567620 337 ADP-ribosylation factor GTPase-activating protein AGD12

Identical Sequences to LMP009799 proteins

Reference Database Accession Length Protein Name
GI:18415638 GenBank AEE84411.1 337 ADP-ribosylation factor GTPase-activating protein AGD12 [Arabidopsis thaliana]
GI:18415638 GenBank AEE84412.1 337 ADP-ribosylation factor GTPase-activating protein AGD12 [Arabidopsis thaliana]
GI:18415638 GenBank AEE84413.1 337 ADP-ribosylation factor GTPase-activating protein AGD12 [Arabidopsis thaliana]
GI:18415638 GenBank AEE84414.1 337 ADP-ribosylation factor GTPase-activating protein AGD12 [Arabidopsis thaliana]
GI:18415638 RefSeq NP_974582.1 337 ADP-ribosylation factor GTPase-activating protein AGD12 [Arabidopsis thaliana]
GI:18415638 SwissProt Q9FVJ3.1 337 RecName: Full=ADP-ribosylation factor GTPase-activating protein AGD12; Short=ARF GAP AGD12; AltName: Full=Protein ARF-GAP DOMAIN 12; Short=AtAGD12; AltName: Full=Zinc- and calcium-binding protein; Short=AtZAC [Arabidopsis thaliana]

Related Sequences to LMP009799 proteins

Reference Database Accession Length Protein Name
GI:18415638 DBBJ BAF01268.1 337 hypothetical protein [Arabidopsis thaliana]
GI:18415638 EMBL CAA17535.1 369 putative protein [Arabidopsis thaliana]
GI:18415638 EMBL CAB79116.1 369 putative protein [Arabidopsis thaliana]
GI:18415638 GenBank AAM65970.1 337 putative GTPase activating protein [Arabidopsis thaliana]
GI:18415638 RefSeq XP_010434226.1 337 PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD12 isoform X1 [Camelina sativa]
GI:18415638 RefSeq XP_010434227.1 337 PREDICTED: ADP-ribosylation factor GTPase-activating protein AGD12 isoform X1 [Camelina sativa]