Gene/Proteome Database (LMPD)

LMPD ID
LMP009946
Gene ID
830067
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
myo-inositol monophosphatase like 2
Gene Symbol
IMPL2
Synonyms
HISN7; HISTIDINE BIOSYNTHESIS 7; IMPL2; myo-inositol monophosphatase like 2; T22F8.20; T22F8_20
Alternate Names
myo-inositol monophosphatase like 2
Chromosome
4
EC Number
3.1.3.15
Summary
Encodes a chloroplast-localized member of the myo-inositol monophosphatase family, IMPL2 (myo-Inositol monophosphatase like 2) that seems to have multiple enzymatic activities. It contributes to histidine biosynthesis based on it histidinol-phosphate phosphatase activity. In addition, the protein can act as an inositol monophosphatase and an L-galactose-1-phosphate phosphatase in vitro.
Orthologs
View orthologs and multiple alignments for IMPL2

Proteins

myo-inositol monophosphatase like 2
Refseq ID NP_195623
Protein GI 334187306
UniProt ID Q6NPM8
mRNA ID NM_120072
Length 375
RefSeq Status REVIEWED
MRLHNRDLSIQTFSVVDDWLFRELPTHSKMLAQSHFFSKSFDLIPPQSPALRSANPSLRISSSYSNSRLSFLSSSAIAVPVSRRRFCLTMASNSKRPNISNESPSELSDTELDRFAAVGNALADASGEVIRKYFRKKFDIVDKDDMSPVTIADQMAEEAMVSIIFQNLPSHAIYGEEKGWRCKEESADYVWVLDPIDGTKSFITGKPVFGTLIALLYKGKPILGLIDQPILKERWIGMNGRRTKLNGEDISTRSCPKLSQAYLYTTSPHLFSEEAEKAYSRVRDKVKVPLYGCDCYAYALLASGFVDLVIESGLKPYDFLALVPVIEGAGGTITDWTGKRFLWEASSSAVATSFNVVAAGDSDIHQQALESLEWH

Gene Information

Entrez Gene ID
830067
Gene Name
myo-inositol monophosphatase like 2
Gene Symbol
IMPL2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:UniProtKB C chloroplast
GO:0004401 IGI:UniProtKB F histidinol-phosphatase activity
GO:0008934 IEA:UniProtKB-EC F inositol monophosphate 1-phosphatase activity
GO:0052832 IEA:UniProtKB-EC F inositol monophosphate 3-phosphatase activity
GO:0052833 IEA:UniProtKB-EC F inositol monophosphate 4-phosphatase activity
GO:0052834 IGI:UniProtKB F inositol monophosphate phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016311 IGI:GOC P dephosphorylation
GO:0000105 IGI:UniProtKB P histidine biosynthetic process
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-882 L-ascorbate biosynthesis I (L-galactose pathway)
HISTSYN-PWY histidine biosynthesis
PWY-2301 myo-inositol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR011809 Histidinol-phosphate phosphatase, putative, inositol monophosphatase
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
myo-inositol monophosphatase like 2
Protein Entry
HIS7_ARATH
UniProt ID
Q6NPM8
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
Catalytic Activity Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental Stage Expressed at all developmental stages. Detected in globular to heart stage embryos. {ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.
Disruption Phenotype Embryo lethality. {ECO:0000269|PubMed:19339506, ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.
Function Phosphatase required for histidine production. Acts also on L-galactose 1-phosphate (L-Gal 1-P), D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P). {ECO:0000269|PubMed:19339506, ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.
Miscellaneous No redundancy with IMPL1 or VTC4.
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
Sequence Caution Sequence=AEE87019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC43548.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB43627.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB80575.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the inositol monophosphatase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast {ECO:0000269|PubMed:18431481, ECO:0000269|PubMed:20023146}.
Tissue Specificity Ubiquitous. High expression in roots. Expressed in pistil and seed endosperm. {ECO:0000269|PubMed:20023146, ECO:0000269|PubMed:20960216}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009946 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
334187306 RefSeq NP_195623 375 myo-inositol monophosphatase like 2

Identical Sequences to LMP009946 proteins

Reference Database Accession Length Protein Name
GI:334187306 GenBank AEE87019.1 375 myo-inositol monophosphatase like 2 [Arabidopsis thaliana]

Related Sequences to LMP009946 proteins

Reference Database Accession Length Protein Name
GI:334187306 DBBJ BAD43296.1 346 Inositol monophosphatase - like protein [Arabidopsis thaliana]
GI:334187306 DBBJ BAD93756.1 346 Inositol monophosphatase - like protein [Arabidopsis thaliana]
GI:334187306 EMBL CBG10455.1 346 unnamed protein product [Arabidopsis thaliana]
GI:334187306 GenBank AAR24669.1 346 At4g39120 [Arabidopsis thaliana]
GI:334187306 GenBank AGY02015.1 346 Sequence 84236 from patent US 8541208
GI:334187306 SwissProt Q6NPM8.1 346 RecName: Full=Bifunctional phosphatase IMPL2, chloroplastic; AltName: Full=Histidinol-phosphatase; AltName: Full=Histidinol-phosphate phosphatase; Short=HPP; AltName: Full=Inositol-phosphate phosphatase; AltName: Full=Protein HISTIDINE BIOSYNTHESIS 7; AltName: Full=Protein MYO-INOSITOL MONOPHOSPHATASE-LIKE 2; Flags: Precursor [Arabidopsis thaliana]