Gene/Proteome Database (LMPD)

LMPD ID
LMP010020
Gene ID
836595
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
cellulose synthase A catalytic subunit 6 [UDP-forming]
Gene Symbol
CESA6
Synonyms
cellulose synthase 6; CESA6; E112; ISOXABEN RESISTANT 2; IXR2; MVP7.7; MVP7_7; PRC1; PROCUSTE 1
Alternate Names
cellulose synthase A catalytic subunit 6 [UDP-forming]
Chromosome
5
EC Number
2.4.1.12

Proteins

cellulose synthase A catalytic subunit 6 [UDP-forming]
Refseq ID NP_201279
Protein GI 15238231
UniProt ID Q94JQ6
mRNA ID NM_125870
Length 1084
RefSeq Status REVIEWED
MNTGGRLIAGSHNRNEFVLINADENARIRSVQELSGQTCQICRDEIELTVDGEPFVACNECAFPVCRPCYEYERREGNQACPQCKTRFKRLKGSPRVEGDEEEDDIDDLDNEFEYGNNGIGFDQVSEGMSISRRNSGFPQSDLDSAPPGSQIPLLTYGDEDVEISSDRHALIVPPSLGGHGNRVHPVSLSDPTVAAHPRPMVPQKDLAVYGYGSVAWKDRMEEWKRKQNEKLQVVRHEGDPDFEDGDDADFPMMDEGRQPLSRKIPIKSSKINPYRMLIVLRLVILGLFFHYRILHPVKDAYALWLISVICEIWFAVSWVLDQFPKWYPIERETYLDRLSLRYEKEGKPSGLSPVDVFVSTVDPLKEPPLITANTVLSILAVDYPVDKVACYVSDDGAAMLTFEALSETAEFARKWVPFCKKYCIEPRAPEWYFCHKMDYLKNKVHPAFVRERRAMKRDYEEFKVKINALVATAQKVPEDGWTMQDGTPWPGNSVRDHPGMIQVFLGSDGVRDVENNELPRLVYVSREKRPGFDHHKKAGAMNSLIRVSGVLSNAPYLLNVDCDHYINNSKALREAMCFMMDPQSGKKICYVQFPQRFDGIDRHDRYSNRNVVFFDINMKGLDGLQGPIYVGTGCVFRRQALYGFDAPKKKKGPRKTCNCWPKWCLLCFGSRKNRKAKTVAADKKKKNREASKQIHALENIEEGRVTKGSNVEQSTEAMQMKLEKKFGQSPVFVASARMENGGMARNASPACLLKEAIQVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHSHGWRSVYCTPKLAAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPIWYGYGGGLKWLERLSYINSVVYPWTSLPLIVYCSLPAICLLTGKFIVPEISNYASILFMALFSSIAITGILEMQWGKVGIDDWWRNEQFWVIGGVSAHLFALFQGLLKVLAGVDTNFTVTSKAADDGEFSDLYLFKWTSLLIPPMTLLIINVIGVIVGVSDAISNGYDSWGPLFGRLFFALWVIIHLYPFLKGLLGKQDRMPTIIVVWSILLASILTLLWVRVNPFVAKGGPILEICGLDCL

Gene Information

Entrez Gene ID
836595
Gene Name
cellulose synthase A catalytic subunit 6 [UDP-forming]
Gene Symbol
CESA6
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:TAIR C Golgi apparatus
GO:0010330 NAS:TAIR C cellulose synthase complex
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:TAIR C membrane
GO:0005886 IDA:TAIR C plasma membrane
GO:0016760 IEA:UniProtKB-EC F cellulose synthase (UDP-forming) activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0016049 IMP:TAIR P cell growth
GO:0071555 IEA:UniProtKB-KW P cell wall organization
GO:0030244 IMP:TAIR P cellulose biosynthetic process
GO:0043622 IMP:TAIR P cortical microtubule organization
GO:0009833 IMP:TAIR P primary cell wall biogenesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-1001 cellulose biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR005150 Cellulose synthase
IPR027934 Cellulose synthase, RING-type zinc finger
IPR029044 Nucleotide-diphospho-sugar transferases
IPR001841 Zinc finger, RING-type
IPR013083 Zinc finger, RING/FYVE/PHD-type

UniProt Annotations

Entry Information

Gene Name
cellulose synthase A catalytic subunit 6 [UDP-forming]
Protein Entry
CESA6_ARATH
UniProt ID
Q94JQ6
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
Developmental Stage Not found in embryos. Higher levels in tissues undergoing primary cell wall formation, and drop of expression when secondary wall synthesis takes place. High levels in developing seedlings and elongating stems, with a decrease at later growth stages. {ECO:0000269|PubMed:11148287}.
Function Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. The presence of each protein CESA1 and CESA6 is critical for cell expansion. The hypocotyl elongation is based on a CESA6-dependent cell elongation in dark and a CESA6-independent cell elongation in light. The transition between these two mechanisms requires photosynthesis and PHYB, but not CRY1. The CESA6-dependent cell elongation seems to be independent of gibberellic acid, auxin and ethylene. May be involved in sensitivity to isoxaben. Associates with and moves along cortical microtubules for the process of cellulose deposition. {ECO:0000269|PubMed:11148287, ECO:0000269|PubMed:11842152, ECO:0000269|PubMed:16627697, ECO:0000269|PubMed:17878302, ECO:0000269|PubMed:17878303, ECO:0000269|PubMed:7743935, ECO:0000269|PubMed:8625819}.
Pathway Glycan metabolism; plant cellulose biosynthesis.
Sequence Caution Sequence=AAC29067.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK53023.1; Type=Frameshift; Positions=645; Evidence={ECO:0000305};
Similarity Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. {ECO:0000305}.
Similarity Contains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Subunit Interacts with CESA1 and CESA3. {ECO:0000269|PubMed:17878302, ECO:0000269|PubMed:17878303}.
Tissue Specificity Expressed in germinating seeds, seedlings, roots, stems, leaves and flowers. Not present in mature flowers. {ECO:0000269|PubMed:11148287, ECO:0000269|PubMed:12481071}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010020 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15238231 RefSeq NP_201279 1084 cellulose synthase A catalytic subunit 6 [UDP-forming]

Identical Sequences to LMP010020 proteins

Reference Database Accession Length Protein Name
GI:15238231 EMBL CBC92859.1 1084 unnamed protein product [Arabidopsis thaliana]
GI:15238231 EMBL CBC93623.1 1084 unnamed protein product [Arabidopsis thaliana]
GI:15238231 GenBank AFL33710.1 1084 Sequence 28 from patent US 8173866
GI:15238231 GenBank AFX48895.1 1084 Sequence 50728 from patent US 8299318
GI:15238231 GenBank AID66000.1 1084 glycosyltransferase, partial [Arabidopsis thaliana]
GI:15238231 gnl TAIR 1084 cellulose synthase A catalytic subunit 6 [UDP-forming] [Arabidopsis thaliana]

Related Sequences to LMP010020 proteins

Reference Database Accession Length Protein Name
GI:15238231 GenBank AFX28255.1 3678 Sequence 9315 from patent US 8299318
GI:15238231 GenBank AFX48894.1 3678 Sequence 50727 from patent US 8299318
GI:15238231 GenBank AGF13946.1 3678 Sequence 13365 from patent US 8362325
GI:15238231 GenBank EOA12641.1 1084 hypothetical protein CARUB_v10027598mg [Capsella rubella]
GI:15238231 RefSeq XP_006279743.1 1084 hypothetical protein CARUB_v10027598mg [Capsella rubella]
GI:15238231 RefSeq XP_010484268.1 1084 PREDICTED: cellulose synthase A catalytic subunit 6 [UDP-forming] [Camelina sativa]