Gene/Proteome Database (LMPD)

LMPD ID
LMP010141
Gene ID
827307
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
dihydrolipoyl dehydrogenase
Gene Symbol
AT4G16155
Alternate Names
dihydrolipoyl dehydrogenase
Chromosome
4
EC Number
1.8.1.4

Proteins

dihydrolipoyl dehydrogenase
Refseq ID NP_567487
Protein GI 240255914
UniProt ID F4JLP5
mRNA ID NM_117711
Length 630
RefSeq Status REVIEWED
MGSELDIIAGNFEISGLKTRNVTRVISALISPPPLVGVRLVQTCHLRHSLFLYTDLSFTLSYTMQSVLSLSFSQASLPLANRTLCSSNAAPSTPRNLRFCGLRREAFCFSPSKQLTSCRFHIQSRRIEVSAAASSSAGNGAPSKSFDYDLIIIGAGVGGHGAALHAVEKGLKTAIIEGDVVGGTCVNRGCVPSKALLAVSGRMRELQNEHHMKAFGLQVSAAGYDRQGVADHASNLATKIRNNLTNSMKALGVDILTGFGAVLGPQKVKYGDNIITGKDIIIATGSVPFVPKGIEVDGKTVITSDHALKLESVPDWIAIVGSGYIGLEFSDVYTALGSEVTFIEALDQLMPGFDPEISKLAQRVLINTRKIDYHTGVFASKITPAKDGKPVLIELIDAKTKEPKDTLEVDAALIATGRAPFTNGLGLENINVTTQRGFIPVDERMRVIDGNGKLVPHLYCIGDANGKLMLAHAASAQGISVVEQVTGRDHVLNHLSIPAACFTHPEISMVGLTEPQAREKAEKEGFKVSIAKTSFKANTKALAENEGEGLAKMIYRPDNGEILGVHIFGLHAADLIHEASNAIALGTRIQDIKLAVHAHPTLSEVVDELFKAAKVDSPASVTAQSVKVTV

Gene Information

Entrez Gene ID
827307
Gene Name
dihydrolipoyl dehydrogenase
Gene Symbol
AT4G16155
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0009570 IDA:TAIR C chloroplast stroma
GO:0004148 IEA:UniProtKB-EC F dihydrolipoyl dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0045454 IEA:InterPro P cell redox homeostasis
GO:0046685 IMP:UniProtKB P response to arsenic-containing substance

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00260 Glycine, serine and threonine metabolism
ath00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

UniProt Annotations

Entry Information

Gene Name
dihydrolipoyl dehydrogenase
Protein Entry
PLPD2_ARATH
UniProt ID
F4JLP5
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
Disruption Phenotype Arsenate hypersensitivity. {ECO:0000269|PubMed:20488895}.
Function Lipoamide dehydrogenase is a component of the plastidial pyruvate dehydrogenase complex (PDC). {ECO:0000269|PubMed:11056213}.
Miscellaneous The active site is a redox-active disulfide bond. {ECO:0000250}.
Sequence Caution Sequence=AEE83704.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast stroma {ECO:0000250}.
Subunit Homodimer (By similarity). Part of the plastidial pyruvate dehydrogenase complex (PDC) containing multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000250}.
Tissue Specificity Expressed mainly in flower buds and immature siliques, and to a lesser extend in flowers. {ECO:0000269|PubMed:11056213}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010141 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
240255914 RefSeq NP_567487 630 dihydrolipoyl dehydrogenase

Identical Sequences to LMP010141 proteins

Reference Database Accession Length Protein Name
GI:240255914 GenBank AEE83704.1 630 dihydrolipoyl dehydrogenase [Arabidopsis thaliana]

Related Sequences to LMP010141 proteins

Reference Database Accession Length Protein Name
GI:240255914 GenBank AAL06856.1 567 AT3g16950/K14A17_7 [Arabidopsis thaliana]
GI:240255914 GenBank AAM45006.1 567 unknown protein [Arabidopsis thaliana]
GI:240255914 GenBank AAV24574.1 567 Sequence 30 from patent US 6764851
GI:240255914 GenBank ABA65432.1 567 Sequence 30 from patent US 6942994
GI:240255914 GenBank ACR90702.1 567 Sequence 30 from patent US 7524678
GI:240255914 SwissProt F4JLP5.2 567 RecName: Full=Dihydrolipoyl dehydrogenase 2, chloroplastic; Short=ptLPD2; AltName: Full=Dihydrolipoamide dehydrogenase 2; AltName: Full=Protein LIPOAMIDE DEHYDROGENASE 2; AltName: Full=Pyruvate dehydrogenase complex E3 subunit 2; Short=E3-2; Short=PDC-E3 2; Flags: Precursor [Arabidopsis thaliana]