Gene/Proteome Database (LMPD)

LMPD ID
LMP010146
Gene ID
835598
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1
Gene Symbol
AT5G55070
Synonyms
MCO15.2; MCO15_2
Alternate Names
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1
Chromosome
5
EC Number
2.3.1.61

Proteins

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1
Refseq ID NP_200318
Protein GI 15240454
UniProt ID Q9FLQ4
mRNA ID NM_124889
Length 464
RefSeq Status REVIEWED
MMLRAVFRRASIRGSSSASGLGKSLQSSRVAVSAQFHSVSATETLVPRGNHAHSFHHRSCPGCPDCSRTIINGYQGTALQRWVRPFSSDSGDVVEAVVPHMGESITDGTLAAFLKKPGDRVEADEAIAQIETDKVTIDIASPASGVIQEFLVKEGDTVEPGNKVARISTSADAVSHVAPSEKAPEKPAPKPSPPAEKPKVESTKVAEKPKAPSPPPPPPSKQSAKEPQLPPKDRERRVPMTRLRKRVATRLKDSQNTFALLTTFNEVDMTNLMKLRSQYKDAFLEKHGVKLGLMSGFIKAAVSALQHQPVVNAVIDGDDIIYRDYVDISIAVGTSKGLVVPVIRDADKMNFADIEKTINGLAKKATEGTISIDEMAGGSFTVSNGGVYGSLISTPIINPPQSAILGMHSIVQRPMVVGGSVVPRPMMYVALTYDHRLIDGREAVYFLRRIKDVVEDPQRLLLDI

Gene Information

Entrez Gene ID
835598
Gene Name
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1
Gene Symbol
AT5G55070
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0022626 IDA:TAIR C cytosolic ribosome
GO:0005739 IDA:TAIR C mitochondrion
GO:0045252 IEA:InterPro C oxoglutarate dehydrogenase complex
GO:0004149 IEA:UniProtKB-EC F dihydrolipoyllysine-residue succinyltransferase activity
GO:0008270 IDA:TAIR F zinc ion binding
GO:0033512 IEA:UniProtKB-UniPathway P L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0006979 IDA:TAIR P response to oxidative stress
GO:0006099 IEA:UniProtKB-KW P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00310 Lysine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
6253685 Lysine catabolism

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006255 Dihydrolipoamide succinyltransferase
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1
Protein Entry
ODO2A_ARATH
UniProt ID
Q9FLQ4
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000250};
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
Pathway Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:14671022}.
Subunit Forms a 24-polypeptide structural core with octahedral symmetry. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010146 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15240454 RefSeq NP_200318 464 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1

Identical Sequences to LMP010146 proteins

Reference Database Accession Length Protein Name
GI:15240454 DBBJ BAB08576.1 464 2-oxoglutarate dehydrogenase E2 subunit [Arabidopsis thaliana]
GI:15240454 GenBank AAK68837.1 464 2-oxoglutarate dehydrogenase E2 subunit [Arabidopsis thaliana]
GI:15240454 GenBank AAM91126.1 464 2-oxoglutarate dehydrogenase E2 subunit [Arabidopsis thaliana]
GI:15240454 gnl TAIR 464 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1 [Arabidopsis thaliana]
GI:15240454 SwissProt Q9FLQ4.1 464 RecName: Full=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E2-1; Short=OGDC-E2-1; AltName: Full=Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1; AltName: Full=E2K-1; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010146 proteins

Reference Database Accession Length Protein Name
GI:15240454 EMBL CAA11553.1 462 2-oxoglutarate dehydrogenase E2 subunit [Arabidopsis thaliana]
GI:15240454 GenBank EFH40632.1 463 2-oxoglutarate dehydrogenase E2 subunit [Arabidopsis lyrata subsp. lyrata]
GI:15240454 RefSeq XP_002864373.1 463 2-oxoglutarate dehydrogenase E2 subunit [Arabidopsis lyrata subsp. lyrata]
GI:15240454 RefSeq XP_010449000.1 462 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [Camelina sativa]
GI:15240454 RefSeq XP_010449007.1 462 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [Camelina sativa]
GI:15240454 RefSeq XP_010482928.1 464 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial [Camelina sativa]