Gene/Proteome Database (LMPD)

LMPD ID
LMP010147
Gene ID
828798
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Dihydrolipoamide succinyltransferase
Gene Symbol
AT4G26910
Synonyms
F10M23.250; F10M23_250
Alternate Names
Dihydrolipoamide succinyltransferase
Chromosome
4
EC Number
2.3.1.61

Proteins

Dihydrolipoamide succinyltransferase
Refseq ID NP_849453
Protein GI 30687411
UniProt ID Q8H107
mRNA ID NM_179122
Length 365
RefSeq Status REVIEWED
MGESITDGTLATFLKKPGERVQADEAIAQIETDKVTIDIASPASGVIQEFLVNEGDTVEPGTKVAIISKSEDTASQVTPSQKIPETTDTKPSPPAEDKQKPRVESAPVAEKPKAPSSPPPPKQSAKEPQLPPKERERRVPMTRLRKRVATRLKDSQNTFALLTTFNEVDMTNLMKLRSQYKDAFYEKHGVKLGLMSGFIKAAVSALQHQPVVNAVIDGDDIIYRDYVDISIAVGTSKGLVVPVIRGADKMNFAEIEKTINSLAKKANEGTISIDEMAGGSFTVSNGGVYGSLISTPIINPPQSAILGMHSIVSRPMVVGGSVVPRPMMYVALTYDHRLIDGREAVYFLRRVKDVVEDPQRLLLDI
Dihydrolipoamide succinyltransferase
Refseq ID NP_567761
Protein GI 18416889
UniProt ID Q8H107
mRNA ID NM_118825
Length 464
RefSeq Status REVIEWED
MMMRAVIRRAASNGSSPSLFAKSLQSSRVAASSPSLLSGSETGAYLHRGNHAHSFHNLALPAGNSGISRSASLVSSTLQRWVRPFSAETGDTVEAVVPHMGESITDGTLATFLKKPGERVQADEAIAQIETDKVTIDIASPASGVIQEFLVNEGDTVEPGTKVAIISKSEDTASQVTPSQKIPETTDTKPSPPAEDKQKPRVESAPVAEKPKAPSSPPPPKQSAKEPQLPPKERERRVPMTRLRKRVATRLKDSQNTFALLTTFNEVDMTNLMKLRSQYKDAFYEKHGVKLGLMSGFIKAAVSALQHQPVVNAVIDGDDIIYRDYVDISIAVGTSKGLVVPVIRGADKMNFAEIEKTINSLAKKANEGTISIDEMAGGSFTVSNGGVYGSLISTPIINPPQSAILGMHSIVSRPMVVGGSVVPRPMMYVALTYDHRLIDGREAVYFLRRVKDVVEDPQRLLLDI
Dihydrolipoamide succinyltransferase
Refseq ID NP_849452
Protein GI 30687405
UniProt ID Q8H107
mRNA ID NM_179121
Length 463
RefSeq Status REVIEWED
MMMRAVIRRAASNGSSPSLFAKSLQSSRVAASSPSLLSGSETGAYLHRGNHAHSFHNLALPGNSGISRSASLVSSTLQRWVRPFSAETGDTVEAVVPHMGESITDGTLATFLKKPGERVQADEAIAQIETDKVTIDIASPASGVIQEFLVNEGDTVEPGTKVAIISKSEDTASQVTPSQKIPETTDTKPSPPAEDKQKPRVESAPVAEKPKAPSSPPPPKQSAKEPQLPPKERERRVPMTRLRKRVATRLKDSQNTFALLTTFNEVDMTNLMKLRSQYKDAFYEKHGVKLGLMSGFIKAAVSALQHQPVVNAVIDGDDIIYRDYVDISIAVGTSKGLVVPVIRGADKMNFAEIEKTINSLAKKANEGTISIDEMAGGSFTVSNGGVYGSLISTPIINPPQSAILGMHSIVSRPMVVGGSVVPRPMMYVALTYDHRLIDGREAVYFLRRVKDVVEDPQRLLLDI

Gene Information

Entrez Gene ID
828798
Gene Name
Dihydrolipoamide succinyltransferase
Gene Symbol
AT4G26910
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:TAIR C membrane
GO:0005739 IDA:TAIR C mitochondrion
GO:0045252 IEA:InterPro C oxoglutarate dehydrogenase complex
GO:0004149 IEA:UniProtKB-EC F dihydrolipoyllysine-residue succinyltransferase activity
GO:0008270 IDA:TAIR F zinc ion binding
GO:0033512 IEA:UniProtKB-UniPathway P L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0006099 IEA:UniProtKB-KW P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00310 Lysine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
6253685 Lysine catabolism

Domain Information

InterPro Annotations

Accession Description
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006255 Dihydrolipoamide succinyltransferase
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
Dihydrolipoamide succinyltransferase
Protein Entry
ODO2B_ARATH
UniProt ID
Q8H107
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8H107-1; Sequence=Displayed; Name=2; IsoId=Q8H107-2; Sequence=VSP_039870; Name=3; IsoId=Q8H107-3; Sequence=VSP_039869; Note=May be due to an intron retention. No experimental confirmation available.;
Catalytic Activity Succinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000250}; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000250};
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
Pathway Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
Sequence Caution Sequence=AAM67267.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AY096643; Type=Frameshift; Positions=207; Evidence={ECO:0000305}; Sequence=CAB36537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB79546.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:14671022}.
Subunit Forms a 24-polypeptide structural core with octahedral symmetry. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010147 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18416889 RefSeq NP_567761 464 Dihydrolipoamide succinyltransferase
30687405 RefSeq NP_849452 463 Dihydrolipoamide succinyltransferase
30687411 RefSeq NP_849453 365 Dihydrolipoamide succinyltransferase

Identical Sequences to LMP010147 proteins

Reference Database Accession Length Protein Name
GI:30687405 DBBJ BAH20297.1 463 AT4G26910 [Arabidopsis thaliana]
GI:30687405 GenBank AAN41326.1 463 putative dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687411 GenBank AEE85267.1 365 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687405 GenBank AEE85268.1 463 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:18416889 GenBank AEE85269.1 464 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:18416889 SwissProt Q8H107.2 464 RecName: Full=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E2-2; Short=OGDC-E2-2; AltName: Full=Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2; AltName: Full=E2K-2; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010147 proteins

Reference Database Accession Length Protein Name
GI:30687411 DBBJ BAH20297.1 463 AT4G26910 [Arabidopsis thaliana]
GI:18416889 DBBJ BAH20297.1 463 AT4G26910 [Arabidopsis thaliana]
GI:30687405 GenBank AAM67267.1 463 putative dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:18416889 GenBank AAM67267.1 463 putative dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687411 GenBank AAN41326.1 463 putative dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:18416889 GenBank AAN41326.1 463 putative dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687405 GenBank EFH43794.1 464 hypothetical protein ARALYDRAFT_492108 [Arabidopsis lyrata subsp. lyrata]
GI:18416889 GenBank AEE85268.1 463 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687411 GenBank AEE85268.1 463 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687405 GenBank AEE85269.1 464 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687405 RefSeq NP_567761.1 464 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687411 RefSeq NP_567761.1 464 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687411 RefSeq NP_849452.1 463 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:18416889 RefSeq NP_849452.1 463 Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]
GI:30687405 RefSeq XP_002867535.1 464 hypothetical protein ARALYDRAFT_492108 [Arabidopsis lyrata subsp. lyrata]
GI:18416889 RefSeq XP_002867535.1 464 hypothetical protein ARALYDRAFT_492108 [Arabidopsis lyrata subsp. lyrata]
GI:30687411 SwissProt Q8H107.2 464 RecName: Full=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E2-2; Short=OGDC-E2-2; AltName: Full=Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2; AltName: Full=E2K-2; Flags: Precursor [Arabidopsis thaliana]
GI:30687405 SwissProt Q8H107.2 464 RecName: Full=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E2-2; Short=OGDC-E2-2; AltName: Full=Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2; AltName: Full=E2K-2; Flags: Precursor [Arabidopsis thaliana]