Gene/Proteome Database (LMPD)

LMPD ID
LMP010237
Gene ID
829042
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
gamma-glutamyl transpeptidase 4
Gene Symbol
GGT4
Synonyms
F17A13.30; F17A13_30; gamma-glutamyl transpeptidase 3; gamma-glutamyl transpeptidase 4; GGT3; GGT4
Alternate Names
gamma-glutamyl transpeptidase 4
Chromosome
4
EC Number
2.3.2.2
Summary
The gene encodes a gamma-glutamyltransferase (AKA gamma-glutamyl transpeptidase, EC 2.3.2.2) that is located in the vacuole and is most active in roots. The encoded enzyme is involved in the initial degradation of glutathione conjugates in this cell compartment. It is also induced by xenobiotics and contributes to xenobiotics metabolism. Note that conflicting nomenclature exists in the literature: At4g29210 is named as GGT3 in Plant J. 2007 Mar 49(5):878-88; At4g29210 is named as GGT4 and At1g69820 as GGT3 in Plant Physiol. 2007 Aug 144(4):1715-32.
Orthologs
View orthologs and multiple alignments for GGT4

Proteins

gamma-glutamyl transpeptidase 4
Refseq ID NP_194650
Protein GI 15233493
UniProt ID Q9M0G0
mRNA ID NM_119065
Length 637
RefSeq Status REVIEWED
MRDAIIADPLLAIDHETVAEKKKQSKNLKISLLLLLILLATSGYYSFSDNITTVFLSRQAIDDDHSLSLGTISDVVESENGVVAADDARCSEIGASVLRSGGHAVDAAVAITLCVGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDMYKNDASAKSLGALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIKLARDGFVVYPYLGKAISTKVAMILKDPGMRSVFSRNGQVLKTGETCYNPELAQSLETISEQGPGAFYNGTVGEKLVKDVKKAGGIITMDDLRSYKVRVTDAMSVDVMGYTVHGMPPPSGGTVGFSMVMNILDSYSNLYTASGRELGLHRLIEAMKHMFAARMDLGDPEFVNVTNSMNQMLSKAHAEEIQKRIFDNTTFPPEYYMNRWSQLRDQGTSHFCVVDADRNSVSMTSTVNYRFGAGVLSPSTGIVLNNEMDDFSTPTEITPDMLPPAPTNFIEPNKRPLSSMTPLVITKDGEFVAALGGAGGMHIIPAVLQVFLNCFVLNMKPKEAVESARIYHRLIPNVVSYENFTTINGDHIGVSEDTKMFLAERGHELKELSGGAIVQLIVQSFKEEKEEEMIIEIGRKIGKKSKPLKGLLTAVSDPRKDGKPAAV
gamma-glutamyl transpeptidase 4
Refseq ID NP_974636
Protein GI 42573079
UniProt ID Q9M0G0
mRNA ID NM_202907
Length 512
RefSeq Status REVIEWED
MRDAIIADPLLAIDHETVAEKKKQSKNLKISLLLLLILLATSGYYSFSDNITTVFLSRQAIDDDHSLSLGTISDVVESENGVVAADDARCSEIGASVLRSGGHAVDAAVAITLCVGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDMYKNDASAKSLGALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIKLARDGFVVYPYLGKAISTKVAMILKDPGMRSVFSRNGQVLKTGETCYNPELAQSLETISEQGPGAFYNGTVGEKLVKDVKKAGGIITMDDLRSYKVRVTDAMSVDVMGYTVHGMPPPSGGTVGFSMVMNILDSYSNLYTASGRELGLHRLIEAMKHMFAARMDLGDPEFVNVTNSMNQMLSKAHAEEIQKRIFDNTTFPPEYYMNRWSQLRDQGTSHFCVVDADRNSVSMTSTVNYRFGAGVLSPSTGIVLNNEMDDFSTPTEITPDMLPPAPTNFIEPNKRPLSSMTPLVITKVHNQYISTFPVIYNS

Gene Information

Entrez Gene ID
829042
Gene Name
gamma-glutamyl transpeptidase 4
Gene Symbol
GGT4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005773 IDA:TAIR C vacuole
GO:0003840 IMP:TAIR F gamma-glutamyltransferase activity
GO:0016756 IDA:TAIR F glutathione gamma-glutamylcysteinyltransferase activity
GO:0036374 IEA:UniProtKB-EC F glutathione hydrolase activity
GO:0006751 IDA:TAIR P glutathione catabolic process
GO:0009636 IEA:UniProtKB-KW P response to toxic substance
GO:0006805 IEP:TAIR P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00590 Arachidonic acid metabolism
ath00460 Cyanoamino acid metabolism
ath00480 Glutathione metabolism
ath00430 Taurine and hypotaurine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000101 Gamma-glutamyltranspeptidase
IPR029055 Nucleophile aminohydrolases, N-terminal

UniProt Annotations

Entry Information

Gene Name
gamma-glutamyl transpeptidase 4
Protein Entry
GAGT3_ARATH
UniProt ID
Q9M0G0
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9M0G0-1; Sequence=Displayed; Name=2; IsoId=Q9M0G0-2; Sequence=VSP_044955, VSP_044956; Note=No experimental confirmation available.;
Catalytic Activity A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Catalytic Activity Glutathione + H(2)O = L-cysteinylglycine + L- glutamate.
Catalytic Activity Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate.
Disruption Phenotype No visible phenotype under normal growth conditions. {ECO:0000269|PubMed:17545509}.
Function May play a role in protecting plants from some xenobiotic chemicals by degrading vacuolar glutathione conjugates into cysteine conjugates. {ECO:0000269|PubMed:17316176}.
Induction By auxin. {ECO:0000269|PubMed:17316176}.
Pathway Sulfur metabolism; glutathione metabolism.
Similarity Belongs to the gamma-glutamyltransferase family. {ECO:0000305}.
Subcellular Location Vacuole membrane {ECO:0000305|PubMed:17316176}; Single-pass membrane protein {ECO:0000305|PubMed:17316176}.
Tissue Specificity Expressed in roots, cotyledons, leaves, flowers and siliques. {ECO:0000269|PubMed:17316176, ECO:0000269|PubMed:17545509, ECO:0000269|PubMed:20959624}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010237 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15233493 RefSeq NP_194650 637 gamma-glutamyl transpeptidase 4
42573079 RefSeq NP_974636 512 gamma-glutamyl transpeptidase 4

Identical Sequences to LMP010237 proteins

Reference Database Accession Length Protein Name
GI:15233493 DBBJ BAF00492.1 637 gamma-glutamyltransferase-like protein [Arabidopsis thaliana]
GI:15233493 EMBL CAB79679.1 637 gamma-glutamyltransferase-like protein [Arabidopsis thaliana]
GI:15233493 GenBank AAO64159.1 637 putative gamma-glutamyltransferase [Arabidopsis thaliana]
GI:15233493 GenBank AEE85602.1 637 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana]
GI:42573079 GenBank AEE85603.1 512 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana]
GI:15233493 SwissProt Q9M0G0.1 637 RecName: Full=Gamma-glutamyltranspeptidase 3; AltName: Full=Gamma-glutamyltransferase 3; AltName: Full=Gamma-glutamyltranspeptidase 4; AltName: Full=Glutathione hydrolase 3 [Arabidopsis thaliana]

Related Sequences to LMP010237 proteins

Reference Database Accession Length Protein Name
GI:42573079 DBBJ BAF00492.1 637 gamma-glutamyltransferase-like protein [Arabidopsis thaliana]
GI:42573079 EMBL CAB79679.1 637 gamma-glutamyltransferase-like protein [Arabidopsis thaliana]
GI:42573079 GenBank AAO64159.1 637 putative gamma-glutamyltransferase [Arabidopsis thaliana]
GI:15233493 GenBank EFH45706.1 639 gamma-glutamyl transpeptidase 3 [Arabidopsis lyrata subsp. lyrata]
GI:42573079 GenBank AEE85602.1 637 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana]
GI:15233493 GenBank ESQ54315.1 639 hypothetical protein EUTSA_v10024658mg [Eutrema salsugineum]
GI:42573079 RefSeq NP_194650.1 637 gamma-glutamyl transpeptidase 4 [Arabidopsis thaliana]
GI:15233493 RefSeq XP_002869447.1 639 gamma-glutamyl transpeptidase 3 [Arabidopsis lyrata subsp. lyrata]
GI:15233493 RefSeq XP_010433124.1 640 PREDICTED: gamma-glutamyltranspeptidase 3-like [Camelina sativa]
GI:15233493 RefSeq XP_010438326.1 637 PREDICTED: gamma-glutamyltranspeptidase 3-like [Camelina sativa]
GI:15233493 RefSeq XP_010447878.1 639 PREDICTED: gamma-glutamyltranspeptidase 3-like [Camelina sativa]
GI:42573079 SwissProt Q9M0G0.1 637 RecName: Full=Gamma-glutamyltranspeptidase 3; AltName: Full=Gamma-glutamyltransferase 3; AltName: Full=Gamma-glutamyltranspeptidase 4; AltName: Full=Glutathione hydrolase 3 [Arabidopsis thaliana]