Gene/Proteome Database (LMPD)

LMPD ID
LMP010535
Gene ID
841944
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lipoxygenase 1
Gene Symbol
LOX1
Synonyms
ARABIDOPSIS LIPOXYGENASE 1; ATLOX1; LIPOXYGENASE; lipoxygenase 1; LOX1
Alternate Names
lipoxygenase 1
Chromosome
1
EC Number
1.13.11.58
Summary
lipoxygenase, a defense gene conferring resistance Xanthomonas campestris
Orthologs
View orthologs and multiple alignments for LOX1

Proteins

lipoxygenase 1
Refseq ID NP_175900
Protein GI 15221970
UniProt ID Q06327
mRNA ID NM_104376
Length 859
RefSeq Status REVIEWED
MFGELRDLLTGGGNETTTKKVKGTVVLMKKNVLDFNDFNASFLDRLHEFLGNKITLRLVSSDVTDSENGSKGKLGKAAHLEDWITTITSLTAGESAFKVTFDYETDFGYPGAFLIRNSHFSEFLLKSLTLEDVPGHGRVHYICNSWIYPAKHYTTDRVFFSNKTYLPHETPATLLKYREEELVSLRGTGEGELKEWDRVYDYAYYNDLGVPPKNPRPVLGGTQEYPYPRRGRTGRKPTKEDPQTESRLPITSSLDIYVPRDERFGHLKMSDFLAYALKAIAQFIQPALEAVFDDTPKEFDSFEDVLKIYEEGIDLPNQALIDSIVKNIPLEMLKEIFRTDGQKFLKFPVPQVIKEDKTAWRTDEEFAREMLAGLNPVVIQLLKEFPPKSKLDSESYGNQNSTITKSHIEHNLDGLTVEEALEKERLFILDHHDTLMPYLGRVNTTTTKTYASRTLLFLKDDGTLKPLVIELSLPHPNGDKFGAVSEVYTPGEGVYDSLWQLAKAFVGVNDSGNHQLISHWMQTHASIEPFVIATNRQLSVLHPVFKLLEPHFRDTMNINALARQILINGGGIFEITVFPSKYAMEMSSFIYKNHWTFPDQALPAELKKRGMAVEDPEAPHGLRLRIKDYPYAVDGLEVWYAIESWVRDYIFLFYKIEEDIQTDTELQAWWKEVREEGHGDKKSEPWWPKMQTREELVESCTIIIWVASALHAAVNFGQYPVAGYLPNRPTISRQYMPKENTPEFEELEKNPDKVFLKTITAQLQTLLGISLIEILSTHSSDEVYLGQRDSKEWAAEKEALEAFEKFGEKVKEIEKNIDERNDDETLKNRTGLVKMPYTLLFPSSEGGVTGRGIPNSVSI

Gene Information

Entrez Gene ID
841944
Gene Name
lipoxygenase 1
Gene Symbol
LOX1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009536 IDA:TAIR C plastid
GO:0005506 IEA:InterPro F iron ion binding
GO:0016165 IEA:InterPro F linoleate 13S-lipoxygenase activity
GO:1990136 IDA:UniProtKB F linoleate 9S-lipoxygenase activity
GO:0010311 IMP:UniProtKB P lateral root formation
GO:0034440 IDA:TAIR P lipid oxidation
GO:0031408 IEA:UniProtKB-UniPathway P oxylipin biosynthetic process
GO:0009737 IEP:UniProtKB P response to abscisic acid
GO:0009753 IEP:UniProtKB P response to jasmonic acid
GO:0048364 IMP:TAIR P root development

KEGG Pathway Links

KEGG Pathway ID Description
ath00591 Linoleic acid metabolism
ko00591 Linoleic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6253812 Arachidonic acid metabolism
6254374 Synthesis of 15-eicosatetraenoic acid derivatives

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR027433 Lipoxygenase, domain 3
IPR020833 Lipoxygenase, iron binding site
IPR001246 Lipoxygenase, plant
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
lipoxygenase 1
Protein Entry
LOX1_ARATH
UniProt ID
Q06327
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy- 10,12-octadecadienoate. {ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:18949503}.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. Iron is tightly bound. {ECO:0000255|PROSITE-ProRule:PRU00726};
Developmental Stage Transiently expressed during germination, within 1 day after imbibition, especially in the epidermis and the aleurone layer. Later present in the epidermis of the radicle and the adaxial side of the cotyledons. In roots, confined to the pericycle cells and in the lateral root primordia (LRP), and declined at the time of lateral root emergence. Expression is greatly increased in leaves during leaf senescence. {ECO:0000269|PubMed:11891244, ECO:0000269|PubMed:12232208, ECO:0000269|PubMed:17369372}.
Disruption Phenotype Increment in the number of lateral roots, and moderate increase in the length of the primary root. {ECO:0000269|PubMed:17369372}.
Function 9S-lipoxygenase that can use linoleic acid or linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Function as regulators of root development by controlling the emergence of lateral roots. {ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:18949503}.
Induction By pathogens (e.g. Pseudomonas syringae), wounding, abscisic acid (ABA) and methyl jasmonate (MeJA). Higher levels in light than in dark conditions. {ECO:0000269|PubMed:12232208, ECO:0000269|PubMed:7506426}.
Pathway Lipid metabolism; oxylipin biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00726}.
Similarity Belongs to the lipoxygenase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Subcellular Location Cytoplasm.
Subunit Monomer.
Tissue Specificity Seedlings, roots, leaves, and flowers (at protein level). {ECO:0000269|PubMed:12232208, ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:7506426, ECO:0000269|Ref.7}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010535 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15221970 RefSeq NP_175900 859 lipoxygenase 1

Identical Sequences to LMP010535 proteins

Reference Database Accession Length Protein Name
GI:15221970 GenBank AAA17036.1 859 lipoxygenase 1 [Arabidopsis thaliana]
GI:15221970 GenBank AAG51123.1 859 lipoxygenase, putative [Arabidopsis thaliana]
GI:15221970 GenBank AAM13103.1 859 lipoxygenase, putative [Arabidopsis thaliana]
GI:15221970 GenBank AAQ56801.1 859 At1g55020 [Arabidopsis thaliana]
GI:15221970 GenBank AEE33175.1 859 lipoxygenase 1 [Arabidopsis thaliana]
GI:15221970 SwissProt Q06327.1 859 RecName: Full=Linoleate 9S-lipoxygenase 1; AltName: Full=Lipoxygenase 1; Short=AtLOX1 [Arabidopsis thaliana]

Related Sequences to LMP010535 proteins

Reference Database Accession Length Protein Name
GI:15221970 GenBank EFH68193.1 857 hypothetical protein ARALYDRAFT_474776 [Arabidopsis lyrata subsp. lyrata]
GI:15221970 GenBank EOA33292.1 859 hypothetical protein CARUB_v10019783mg [Capsella rubella]
GI:15221970 RefSeq XP_002891934.1 857 hypothetical protein ARALYDRAFT_474776 [Arabidopsis lyrata subsp. lyrata]
GI:15221970 RefSeq XP_006300394.1 859 hypothetical protein CARUB_v10019783mg [Capsella rubella]
GI:15221970 RefSeq XP_010414944.1 860 PREDICTED: linoleate 9S-lipoxygenase 1-like [Camelina sativa]
GI:15221970 RefSeq XP_010480214.1 860 PREDICTED: linoleate 9S-lipoxygenase 1 [Camelina sativa]