Gene/Proteome Database (LMPD)
LMPD ID
LMP010544
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lipid phosphate phosphatase 2
Gene Symbol
Synonyms
ATLPP2; ATPAP2; F9L1.2; F9L1_2; lipid phosphate phosphatase 2; LIPID PHOSPHATE PHOSPHATASE 2; LPP2; PHOSPHATIDIC ACID PHOSPHATASE 2
Alternate Names
lipid phosphate phosphatase 2
Chromosome
1
EC Number
3.1.3.-
Summary
Encodes phosphatidic acid phosphatase. Involved in ABA signaling. Functions as a negative regulator upstream of ABI4. Expressed during germination and seed development. Expressed overall in young seedlings, in roots, hypocotyls, and vascular cells of cotyledons and leaves of 10 day-old seedlings, in flower filaments and stem elongation zones. Not expressed in anthers, pollen nor petals.
Orthologs
Proteins
| lipid phosphate phosphatase 2 | |
|---|---|
| Refseq ID | NP_172961 |
| Protein GI | 15218051 |
| UniProt ID | Q9XI60 |
| mRNA ID | NM_101377 |
| Length | 290 |
| RefSeq Status | REVIEWED |
| MPEIHLGAHTIRSHGVTVARFHMHDWLILLLLIVIEIVLNVIEPFHRFVGEDMLTDLRYPLQDNTIPFWAVPLIAVVLPFAVICVYYFIRNDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGIGIFHNVTKNVLCTGAKDVVKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDQRGHVAKLCIVILPLLVAALVGVSRVDDYWHHWQDVFGGAIIGLTVATFCYLQFFPPPYDPDGWGPHAYFQMLADSRNDVQDSAGMNHLSVRQTELESVR | |
Gene Information
Entrez Gene ID
Gene Name
lipid phosphate phosphatase 2
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | ISS:TAIR | C | integral component of plasma membrane |
| GO:0005886 | IDA:TAIR | C | plasma membrane |
| GO:0003993 | ISS:TAIR | F | acid phosphatase activity |
| GO:0008195 | IDA:TAIR | F | phosphatidate phosphatase activity |
| GO:0009738 | IGI:TAIR | P | abscisic acid-activated signaling pathway |
| GO:0016311 | IDA:GOC | P | dephosphorylation |
| GO:0006950 | IEA:UniProtKB-KW | P | response to stress |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-7039 | phosphatidate metabolism, as a signaling molecule |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
lipid phosphate phosphatase 2
Protein Entry
LPP2_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Disruption Phenotype | No visible phenotype under normal growth conditions, but mutant plants show hypersensitivity to ABA and significant PA accumulation during seed germination. {ECO:0000269|PubMed:15960620}. |
| Enzyme Regulation | PA phosphatase activity not inhibited by N- ethylmaleimide. {ECO:0000269|PubMed:11278556}. |
| Function | May play a general "housekeeping role" in lipid metabolism. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities with no preference for either substrate. May play a role downstream of the ABA signaling pathway during seed germination and in stomatal movement in leaves. {ECO:0000269|PubMed:11278556, ECO:0000269|PubMed:15960620, ECO:0000269|PubMed:21277215}. |
| Induction | Constitutively expressed. Not induced by stress, mastoparan or hypersensitive response elicitor harpin. Down- regulated by ABA. {ECO:0000269|PubMed:11278556, ECO:0000269|PubMed:21277215}. |
| Similarity | Belongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in roots, stems, leaves, buds, flowers and siliques. {ECO:0000269|PubMed:11278556, ECO:0000269|PubMed:15960620}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010544 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15218051 | RefSeq | NP_172961 | 290 | lipid phosphate phosphatase 2 |
Identical Sequences to LMP010544 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15218051 | EMBL | CBK51521.1 | 290 | unnamed protein product [Arabidopsis thaliana] |
| GI:15218051 | GenBank | AAO41959.1 | 290 | putative phosphatidic acid phosphatase [Arabidopsis thaliana] |
| GI:15218051 | GenBank | AAO50502.1 | 290 | putative phosphatidic acid phosphatase [Arabidopsis thaliana] |
| GI:15218051 | GenBank | AAO95195.1 | 290 | Sequence 12 from patent US 6495739 |
| GI:15218051 | GenBank | AEE29263.1 | 290 | lipid phosphate phosphatase 2 [Arabidopsis thaliana] |
| GI:15218051 | SwissProt | Q9XI60.1 | 290 | RecName: Full=Lipid phosphate phosphatase 2; Short=AtLPP2; AltName: Full=Phosphatidic acid phosphatase 2; Short=AtPAP2; AltName: Full=Prenyl diphosphate phosphatase [Arabidopsis thaliana] |
Related Sequences to LMP010544 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15218051 | GenBank | EFH66345.1 | 312 | ATPAP2 [Arabidopsis lyrata subsp. lyrata] |
| GI:15218051 | GenBank | EOA36930.1 | 315 | hypothetical protein CARUB_v10009800mg [Capsella rubella] |
| GI:15218051 | RefSeq | XP_002890086.1 | 312 | ATPAP2 [Arabidopsis lyrata subsp. lyrata] |
| GI:15218051 | RefSeq | XP_010496820.1 | 316 | PREDICTED: lipid phosphate phosphatase 2 [Camelina sativa] |
| GI:15218051 | RefSeq | XP_010496826.1 | 316 | PREDICTED: lipid phosphate phosphatase 2 [Camelina sativa] |
| GI:15218051 | RefSeq | XP_010459030.1 | 316 | PREDICTED: lipid phosphate phosphatase 2-like [Camelina sativa] |