Gene/Proteome Database (LMPD)

LMPD ID
LMP010845
Gene ID
835981
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphoinositide phospholipase C 1
Gene Symbol
PLC1
Synonyms
ARABIDOPSIS THALIANA PHOSPHOLIPASE C; ATPLC; ATPLC1; MZN1.12; MZN1_12; PHOSPHOLIPASE C; phospholipase C 1; phospholipase C1; PLC1
Alternate Names
phosphoinositide phospholipase C 1
Chromosome
5
EC Number
3.1.4.11

Proteins

phosphoinositide phospholipase C 1
Refseq ID NP_568881
Protein GI 18424132
UniProt ID Q39032
mRNA ID NM_125254
Length 561
RefSeq Status REVIEWED
MKESFKVCFCCVRNFKVKSSEPPEEIKNLFHDYSQDDRMSADEMLRFVIQVQGETHADINYVKDIFHRLKHHGVFHPRGIHLEGFYRYLLSDFNSPLPLTREVWQDMNQPLSHYFLYTGHNSYLTGNQLNSNSSIEPIVKALRNGVRVIELDLWPNSSGKEAEVRHGGTLTSREDLQKCLNVVKENAFQVSAYPVVLTLEDHLTPILQKKVAKMVSKTFGGSLFQCTDETTECFPSPESLKNKILISTKPPKEYLQTQISKGSTTDESTRAKKISDAEEQVQEEDEESVAIEYRDLISIHAGNRKGGLKNCLNGDPNRVIRLSMSEQWLETLAKTRGPDLVKFTQRNLLRIFPKTTRFDSSNYDPLVGWIHGAQMVAFNMQSHGRYLWMMQGMFKANGGCGYVKKPDVLLSNGPEGEIFDPCSQNLPIKTTLKVKIYTGEGWNMDFPLDHFDRYSPPDFYAKVGIAGVPLDTASYRTEIDKDEWFPIWDKEFEFPLRVPELSLLCITVKDYDSNTQNDFAGQTCFPLSEVRPGIRAVRLHDRAGEVYKHVRLLMRFVLEPR

Gene Information

Entrez Gene ID
835981
Gene Name
phosphoinositide phospholipase C 1
Gene Symbol
PLC1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004629 IDA:TAIR F phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0009738 TAS:TAIR P abscisic acid-activated signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0009737 IMP:TAIR P response to abscisic acid
GO:0009409 IEP:TAIR P response to cold
GO:0009651 IEP:TAIR P response to salt stress
GO:0009414 IEP:TAIR P response to water deprivation

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254172 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
6253932 GPVI-mediated activation cascade
6254346 Signaling by FGFR1 fusion mutants

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phosphoinositide phospholipase C 1
Protein Entry
PLCD1_ARATH
UniProt ID
Q39032
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for secondary responses to abscisic acid signals. {ECO:0000269|PubMed:11340187, ECO:0000269|PubMed:7732004, ECO:0000269|Ref.7}.
Induction By abscisic acid, osmotic stress and environmental stresses such as dehydration, salinity and low temperature. {ECO:0000269|PubMed:7732004, ECO:0000269|Ref.7}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 EF-hand domain. {ECO:0000305}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Expressed in stems, leaves, roots, flowers and siliques. Predominant in the vascular tissues of roots and leaves. {ECO:0000269|PubMed:7732004, ECO:0000269|Ref.7}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010845 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18424132 RefSeq NP_568881 561 phosphoinositide phospholipase C 1

Identical Sequences to LMP010845 proteins

Reference Database Accession Length Protein Name
GI:18424132 EMBL CBU87794.1 561 unnamed protein product [Arabidopsis thaliana]
GI:18424132 EMBL CBU96741.1 561 unnamed protein product [Arabidopsis thaliana]
GI:18424132 GenBank AGD05592.1 561 Sequence 3048 from patent US 8343764
GI:18424132 GenBank AGX54729.1 561 Sequence 9814 from patent US 8541208
GI:18424132 GenBank AGX64169.1 561 Sequence 28448 from patent US 8541208
GI:18424132 gnl TAIR 561 phosphoinositide phospholipase C 1 [Arabidopsis thaliana]

Related Sequences to LMP010845 proteins

Reference Database Accession Length Protein Name
GI:18424132 GenBank AAC05023.1 561 phosphoinositol-specific phospholipase C delta [Arabidopsis thaliana]
GI:18424132 GenBank EFH42542.1 563 ATPLC1 [Arabidopsis lyrata subsp. lyrata]
GI:18424132 GenBank AGD03245.1 568 Sequence 701 from patent US 8343764
GI:18424132 GenBank EOA13152.1 561 hypothetical protein CARUB_v10026170mg [Capsella rubella]
GI:18424132 RefSeq XP_002866283.1 563 ATPLC1 [Arabidopsis lyrata subsp. lyrata]
GI:18424132 RefSeq XP_006280254.1 561 hypothetical protein CARUB_v10026170mg [Capsella rubella]