Gene/Proteome Database (LMPD)
LMPD ID
LMP011251
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
["bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase"]
Gene Symbol
Synonyms
ALTERED EXPRESSION OF APX2 8; ALX8; ATSAL1; FIERY1; FRY1; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 2; HOS2; MBM17.8; MBM17_8; RON1; ROTUNDA 1; SAL1
Alternate Names
bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase
Chromosome
5
EC Number
3.1.3.7
Proteins
| bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase | |
|---|---|
| Refseq ID | NP_201203 |
| Protein GI | 145359623 |
| UniProt ID | Q42546 |
| mRNA ID | NM_125794 |
| Length | 407 |
| RefSeq Status | REVIEWED |
| MMSINCFRTAKAPLQSFVAVRTNSRPRNSSNRLVSVFGRKSSSPSFVTLRVVSSMAYEKELDAAKKAASLAARLCQKVQKALLQSDVQSKSDKSPVTVADYGSQAVVSLVLEKELSSEPFSLVAEEDSGDLRKDGSQDTLERITKLVNDTLATEESFNGSTLSTDDLLRAIDCGTSEGGPNGRHWVLDPIDGTKGFLRGDQYAVALGLLEEGKVVLGVLACPNLPLASIAGNNKNKSSSDEIGCLFFATIGSGTYMQLLDSKSSPVKVQVSSVENPEEASFFESFEGAHSLHDLSSSIANKLGVKAPPVRIDSQAKYGALSRGDGAIYLRFPHKGYREKIWDHVAGAIVVTEAGGIVTDAAGKPLDFSKGKYLDLDTGIIVANEKLMPLLLKAVRDSIAEQEKASAL | |
Gene Information
Entrez Gene ID
Gene Name
["bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase"]
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0008441 | IEA:UniProtKB-EC | F | 3'(2'),5'-bisphosphate nucleotidase activity |
| GO:0004441 | IEA:UniProtKB-EC | F | inositol-1,4-bisphosphate 1-phosphatase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0009738 | IEA:UniProtKB-KW | P | abscisic acid-activated signaling pathway |
| GO:0046854 | IEA:InterPro | P | phosphatidylinositol phosphorylation |
| GO:0006790 | IEA:InterPro | P | sulfur compound metabolic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
["bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase"]
Protein Entry
DPNP1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D- myo-inositol 4-phosphate + phosphate. |
| Catalytic Activity | Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate. |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| Enzyme Regulation | Inhibited by Li(+) (IC(50)=0.20 millimolar) and Na(+) (IC(50)=200 millimolar). |
| Function | Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is also involved in salt tolerance. Acts as a suppressor of virus- and transgene-induced silencing. {ECO:0000269|PubMed:11485991, ECO:0000269|PubMed:17993620, ECO:0000269|PubMed:8721754}. |
| Miscellaneous | Mutation in the FRY1 gene results in super- induction of abscisic acid (ABA)- and stress-responsive genes, due to inositol 1,4,5-trisphosphate (IP3) accumulation. |
| Miscellaneous | Substrate preference is 3'-phosphoadenosine 5'- phosphate (PAP) = adenosine 3'-phosphate 5'-phosphosulfate (PAPS)> inositol 1,4-bisphosphate >> inositol 1,4,5-trisphosphate. No activity observed against 3' or 5'-AMP, inositol monophosphate and fructose-1,6-bisphosphate. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Sequence Caution | Sequence=AED97825.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the inositol monophosphatase family. {ECO:0000305}. |
| Tissue Specificity | Expressed in roots, leaves, stems, flowers and siliques. {ECO:0000269|PubMed:10205895, ECO:0000269|PubMed:11485991}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011251 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 145359623 | RefSeq | NP_201203 | 407 | bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase |
Identical Sequences to LMP011251 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:145359623 | gnl | TAIR | 407 | bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase [Arabidopsis thaliana] |
Related Sequences to LMP011251 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:145359623 | GenBank | EFH41139.1 | 406 | hypothetical protein ARALYDRAFT_496591 [Arabidopsis lyrata subsp. lyrata] |
| GI:145359623 | GenBank | EOA12535.1 | 406 | hypothetical protein CARUB_v10026515mg [Capsella rubella] |
| GI:145359623 | RefSeq | XP_002864880.1 | 406 | hypothetical protein ARALYDRAFT_496591 [Arabidopsis lyrata subsp. lyrata] |
| GI:145359623 | RefSeq | XP_006279637.1 | 406 | hypothetical protein CARUB_v10026515mg [Capsella rubella] |
| GI:145359623 | RefSeq | XP_010461252.1 | 405 | PREDICTED: SAL1 phosphatase-like [Camelina sativa] |
| GI:145359623 | RefSeq | XP_010484166.1 | 405 | PREDICTED: SAL1 phosphatase [Camelina sativa] |