Gene/Proteome Database (LMPD)
Proteins
| squalene monooxygenase 2 | |
|---|---|
| Refseq ID | NP_197802 |
| Protein GI | 15237900 |
| UniProt ID | O65403 |
| mRNA ID | NM_122319 |
| Length | 516 |
| RefSeq Status | REVIEWED |
| MTYAWLWTLLAFVLTWMVFHLIKMKKAATGDLEAEAEARRDGATDVIIVGAGVAGASLAYALAKDGRRVHVIERDLKEPQRFMGELMQAGGRFMLAQLGLEDCLEDIDAQEAKSLAIYKDGKHATLPFPDDKSFPHEPVGRLLRNGRLVQRLRQKAASLSNVQLEEGTVKSLIEEEGVVKGVTYKNSAGEEITAFAPLTVVCDGCYSNLRRSLVDNTEEVLSYMVGYVTKNSRLEDPHSLHLIFSKPLVCVIYQITSDEVRCVAEVPADSIPSISNGEMSTFLKKSMAPQIPETGNLREIFLKGIEEGLPEIKSTATKSMSSRLCDKRGVIVLGDAFNMRHPIIASGMMVALSDICILRNLLKPLPNLSNTKKVSDLVKSFYIIRKPMSATVNTLASIFSQVLVATTDEAREGMRQGCFNYLARGDFKTRGLMTILGGMNPHPLTLVLHLVAITLTSMGHLLSPFPSPRRFWHSLRILAWALQMLGAHLVDEGFKEMLIPTNAAAYRRNYIATTTV | |
Gene Information
Entrez Gene ID
Gene Name
squalene monooxygenase 2
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
| GO:0004506 | IEA:UniProtKB-EC | F | squalene monooxygenase activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00909 | Sesquiterpenoid and triterpenoid biosynthesis |
| ath00100 | Steroid biosynthesis |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O. |
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Function | Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. |
| Miscellaneous | SEQ4 or SEQ5 are unable to complement seq1 mutants. {ECO:0000305|PubMed:17426032}. |
| Pathway | Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. |
| Similarity | Belongs to the squalene monooxygenase family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed mainly in seedlings and inflorescences. {ECO:0000269|PubMed:17426032}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011309 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15237900 | RefSeq | NP_197802 | 516 | squalene monooxygenase 2 |
Identical Sequences to LMP011309 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15237900 | DBBJ | BAB11574.1 | 516 | squalene monooxygenase 2 (squalene epoxidase 2) (SE 2) [Arabidopsis thaliana] |
| GI:15237900 | EMBL | CAA06771.1 | 516 | squalene epoxidase homologue [Arabidopsis thaliana] |
| GI:15237900 | GenBank | AAE55203.1 | 516 | Sequence 2 from patent US 6153815 |
| GI:15237900 | gnl | TAIR | 516 | squalene monooxygenase 2 [Arabidopsis thaliana] |
| GI:15237900 | SwissProt | O65403.1 | 516 | RecName: Full=Squalene epoxidase 4; Short=AtSQE4; AltName: Full=Squalene monooxygenase 2; Short=SE 2 [Arabidopsis thaliana] |
Related Sequences to LMP011309 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15237900 | GenBank | EFH50430.1 | 503 | hypothetical protein ARALYDRAFT_326701 [Arabidopsis lyrata subsp. lyrata] |
| GI:15237900 | GenBank | EOA22647.1 | 519 | hypothetical protein CARUB_v10003339mg [Capsella rubella] |
| GI:15237900 | RefSeq | XP_002874171.1 | 503 | hypothetical protein ARALYDRAFT_326701 [Arabidopsis lyrata subsp. lyrata] |
| GI:15237900 | RefSeq | XP_006289749.1 | 519 | hypothetical protein CARUB_v10003339mg [Capsella rubella] |
| GI:15237900 | RefSeq | XP_010421225.1 | 518 | PREDICTED: squalene epoxidase 4 [Camelina sativa] |
| GI:15237900 | RefSeq | XP_010495422.1 | 523 | PREDICTED: squalene epoxidase 4-like [Camelina sativa] |