Gene/Proteome Database (LMPD)
Proteins
| fibroblast growth factor receptor 3 precursor | |
|---|---|
| Refseq ID | NP_571681 |
| Protein GI | 18858677 |
| UniProt ID | Q9I8X3 |
| mRNA ID | NM_131606 |
| Length | 800 |
| RefSeq Status | PROVISIONAL |
| MVPLCLLLYLATLVFPPVYSAHLLSPEPTDWVSSEVEVFLEDYVAGVGDTVVLSCTPQDFLLPIVWQKDGDAVSSSNRTRVGQKALRIINVSYEDSGVYSCRHAHKSMLLSNYTVKVIDSLSSGDDEDYDEDEDEAGNGNAEAPYWTRSDRMEKKLLAVPAANTVKFRCPAAGNPTPSIHWLKNGKEFKGEQRMGGIKLRHQQWSLVMESAVPSDRGNYTCVVQNKYGSIKHTYQLDVLERSPHRPILQAGLPANQTVVVGSDVEFHCKVYSDAQPHIQWLKHIEVNGSQYGPNGAPYVNVLKTAGINTTDKELEILYLTNVSFEDAGQYTCLAGNSIGYNHHSAWLTVLPAVEMEREDDYADILIYVTSCVLFILTMVIIILCRMWINTQKTLPAPPVQKLSKFPLKRQVSLESNSSMNSNTPLVRIARLSSSDGPMLPNVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPNKPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDPAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRVLSMTSTDEYLDLSVPFEQYSPTCPDSNSTCSSGDDSVFAHDPLPEEPCLPKHHHSNGVIRT | |
Gene Information
Entrez Gene ID
Gene Name
fibroblast growth factor receptor 3
Gene Symbol
Species
Danio rerio
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0005007 | IEA:InterPro | F | fibroblast growth factor-activated receptor activity |
| GO:0006915 | IEA:UniProtKB-KW | P | apoptotic process |
| GO:0008284 | IEA:InterPro | P | positive regulation of cell proliferation |
| GO:0001501 | IEA:InterPro | P | skeletal system development |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028176 | Fibroblast growth factor receptor 3 |
| IPR016248 | Fibroblast growth factor receptor family |
| IPR013098 | Immunoglobulin I-set |
| IPR003598 | Immunoglobulin subtype 2 |
| IPR007110 | Immunoglobulin-like domain |
| IPR013783 | Immunoglobulin-like fold |
| IPR000719 | Protein kinase domain |
| IPR017441 | Protein kinase, ATP binding site |
| IPR011009 | Protein kinase-like domain |
| IPR001245 | Serine-threonine/tyrosine-protein kinase catalytic domain |
| IPR020635 | Tyrosine-protein kinase, catalytic domain |
UniProt Annotations
Entry Information
Gene Name
fibroblast growth factor receptor 3
Protein Entry
FGFR3_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Developmental Stage | Expression occurs in the axial mesoderm, the diencephalon, the anterior hindbrain and the anterior spinal cord. In the hindbrain, a differential expression was detected at several levels of intensity, with the highest expression in the posterior rhombomere 1 that is morphologically distinct from the anterior part, which develops into the cerebellum. {ECO:0000269|PubMed:11287195}. |
| Domain | The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. {ECO:0000250}. |
| Enzyme Regulation | Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity). {ECO:0000250}. |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity). {ECO:0000250}. |
| Ptm | Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}. |
| Similarity | Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}. |
| Similarity | Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Subunit | Monomer. Homodimer after ligand binding (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011496 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18858677 | RefSeq | NP_571681 | 800 | fibroblast growth factor receptor 3 precursor |
Identical Sequences to LMP011496 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18858677 | GenBank | AAF80344.1 | 800 | fibroblast growth factor receptor 3 [Danio rerio] |
| GI:18858677 | GenBank | ADA04688.1 | 800 | Sequence 28 from patent US 7598027 |
| GI:18858677 | GenBank | ADC23723.1 | 800 | Sequence 28 from patent US 7645570 |
| GI:18858677 | GenBank | AFS91902.1 | 800 | Sequence 28 from patent US 8257914 |
| GI:18858677 | GenBank | AGU27968.1 | 800 | Sequence 28 from patent US 8497081 |
| GI:18858677 | SwissProt | Q9I8X3.1 | 800 | RecName: Full=Fibroblast growth factor receptor 3; Short=FGFR-3; Flags: Precursor [Danio rerio] |
Related Sequences to LMP011496 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18858677 | EMBL | CAM73234.1 | 802 | fgfr3 [Danio rerio] |
| GI:18858677 | GenBank | AAI62517.1 | 800 | Fgfr3 protein [Danio rerio] |
| GI:18858677 | RefSeq | XP_009305458.1 | 821 | PREDICTED: fibroblast growth factor receptor 3 isoform X1 [Danio rerio] |
| GI:18858677 | RefSeq | XP_009305460.1 | 820 | PREDICTED: fibroblast growth factor receptor 3 isoform X3 [Danio rerio] |
| GI:18858677 | RefSeq | XP_009305462.1 | 817 | PREDICTED: fibroblast growth factor receptor 3 isoform X5 [Danio rerio] |
| GI:18858677 | RefSeq | XP_009305463.1 | 816 | PREDICTED: fibroblast growth factor receptor 3 isoform X6 [Danio rerio] |