Gene/Proteome Database (LMPD)
LMPD ID
LMP011641
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
platelet-derived growth factor receptor, alpha polypeptide
Gene Symbol
Synonyms
pdgfr-a; wu:fc27f02; wu:fv91b12; etID309717.20
Alternate Names
platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; platelet derived growth factor receptor alpha; alpha-type platelet-derived growth factor receptor
Chromosome
20
EC Number
2.7.10.1
Proteins
| platelet-derived growth factor receptor alpha | |
|---|---|
| Refseq ID | NP_571534 |
| Protein GI | 33636687 |
| UniProt ID | Q9DE49 |
| mRNA ID | NM_131459 |
| Length | 1059 |
| RefSeq Status | PROVISIONAL |
| MFPVLPQSVQAPLIWPQRESMEVSLHSTFRLTCRGQTELSWNGPVFIDDQTNSVKKGLFISTVTISNATAVHTGEYVCSSEPFNSTESTIYIYVPDPQTPFVPSMTPFENHVLTSYDEMEIPCRVTDPSASVSLIHMGTDQVMPSAYDSKRGFIGLFGAGTYVCRALIHGQNHDSIEYIVHGWTGGSDLRVELRAVKRTLLVGETITVDCVAKGSEVLEDHWKYPGKLANRGPKTVKENKLNLEIYYTLTVTNASPKDSGIYACSITDIMSNESQTKELTITVYDHEFVHINPLIGPVETARLDEVPEFKVDIESFPAPKVTWLKDSSVLGDDTAEISTTLLKIGETSYQGVLNLIRAKAEDSGNYTVKAEIGSISTSYSFYLQVKVPPVIVDLIDVHHGSAAGQEVVCTAGGSPFPEVDWDICKNLKHCANDSSQWMPLPINSTDITVELQMNVDNHIESHIIFHHLEGTVAVRCLARNDMGVVSREVKLMSSGPHSELTVAAAVLVLLVIVIISLIVLVIIWKQKPRYEIRWRVIESVSPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDGFLSRHTEKGKKDLDIFGINPADESSRSYVILSLEGKGDYMDMKQADTMQYVPMLEMNEASKYSPIQRSDYDHPPSHRQFNDEAESLLSDDSAEGLTTMDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLSQGKIVKICDFGLARDIMHDNNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMVVDSSFYNKIKSGYRMTKPEHASSDVYELMMKCWNSEPEKRPSFHSLSDTVASLLPSGFKRCYERVNHDFLKSDHPAVTRVQCIDNDDAYMGVLYKNQGKMKTRESGFDEQRLSSDSGYIIPLPDLDPLSNEDYSKRNRHSSQTSEESAIDTGSSSSTTKREGETLEDITLLDEMCLDSGDLVEDSFL | |
Gene Information
Entrez Gene ID
Gene Name
platelet-derived growth factor receptor, alpha polypeptide
Gene Symbol
Species
Danio rerio
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0005018 | IEA:InterPro | F | platelet-derived growth factor alpha-receptor activity |
| GO:0006935 | IEA:UniProtKB-KW | P | chemotaxis |
| GO:0007275 | IEA:UniProtKB-KW | P | multicellular organismal development |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013098 | Immunoglobulin I-set |
| IPR003599 | Immunoglobulin subtype |
| IPR003598 | Immunoglobulin subtype 2 |
| IPR007110 | Immunoglobulin-like domain |
| IPR013783 | Immunoglobulin-like fold |
| IPR027290 | Platelet-derived growth factor receptor alpha |
| IPR000719 | Protein kinase domain |
| IPR017441 | Protein kinase, ATP binding site |
| IPR011009 | Protein kinase-like domain |
| IPR001245 | Serine-threonine/tyrosine-protein kinase catalytic domain |
| IPR016243 | Tyrosine-protein kinase, CSF-1/PDGF receptor family |
| IPR008266 | Tyrosine-protein kinase, active site |
| IPR020635 | Tyrosine-protein kinase, catalytic domain |
| IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
UniProt Annotations
Entry Information
Gene Name
platelet-derived growth factor receptor, alpha polypeptide
Protein Entry
PGFRA_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}. |
| Developmental Stage | Highly expressed in fertilized eggs as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression started after the onset of segmentation and was mainly localized in the developing pharyngeal arches. Transient expression was also detected in Kupffer's vesicle, a teleost-specific structure, and in lateral trunk and tail regions surrounding the neural keel, as well as areas of the developing pronephros. {ECO:0000269|PubMed:12211169}. |
| Enzyme Regulation | Present in an inactive conformation in the absence of bound ligand. Binding of pdgfa and/or pdgfb leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity). {ECO:0000250}. |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric pdgfa, homodimeric pdgfb, heterodimers formed by pdgfa and pdgfb or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between pdgfra and pdgfrb. Phosphorylates pik3r1, plcg1, and ptpn11. Activation of plcg1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates pik3r1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of hras and of the MAP kinases mapk1/erk2 and/or mapk3/erk1. Promotes activation of STAT family members stat1, stat3 and stat5a and/or stat5b. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity). {ECO:0000250}. |
| Ptm | Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (By similarity). {ECO:0000250}. |
| Ptm | Ubiquitinated, leading to its degradation. {ECO:0000250}. |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}. |
| Similarity | Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}. |
| Similarity | Contains 5 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=The activated receptor is rapidly internalized and degraded. {ECO:0000250}. |
| Subunit | Interacts with homodimeric pdgfa, pdgfb and pdgfc, and with heterodimers formed by pdgfa and pdgfb. Monomer in the absence of bound ligand. Interaction with dimeric pdgfa, pdgfb and/or pdgfc leads to receptor dimerization, where both pdgfra homodimers and heterodimers with pdgfrb are observed (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011641 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 33636687 | RefSeq | NP_571534 | 1059 | platelet-derived growth factor receptor alpha |
Identical Sequences to LMP011641 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:33636687 | GenBank | AAG43479.1 | 1059 | platelet-derived growth factor receptor alpha [Danio rerio] |
| GI:33636687 | SwissProt | Q9DE49.1 | 1059 | RecName: Full=Platelet-derived growth factor receptor alpha; Short=PDGF-R-alpha; Short=PDGFR-alpha; AltName: Full=Alpha platelet-derived growth factor receptor; AltName: Full=Alpha-type platelet-derived growth factor receptor [Danio rerio] |
Related Sequences to LMP011641 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:33636687 | EMBL | CAI11667.1 | 1101 | platelet derived growth factor receptor alpha [Danio rerio] |
| GI:33636687 | EMBL | CAM60067.1 | 1059 | pdgfra, partial [Danio rerio] |
| GI:33636687 | EMBL | CAN88047.1 | 1059 | platelet derived growth factor receptor alpha [Danio rerio] |
| GI:33636687 | EMBL | CAN88048.1 | 1065 | platelet derived growth factor receptor alpha [Danio rerio] |
| GI:33636687 | RefSeq | XP_007257107.1 | 1449 | PREDICTED: platelet-derived growth factor receptor alpha isoform X2 [Astyanax mexicanus] |
| GI:33636687 | RefSeq | XP_007257108.1 | 1449 | PREDICTED: platelet-derived growth factor receptor alpha isoform X3 [Astyanax mexicanus] |