Gene/Proteome Database (LMPD)

LMPD ID
LMP012344
Gene ID
4040
Species
Homo sapiens (Human)
Gene Name
low density lipoprotein receptor-related protein 6
Gene Symbol
LRP6
Synonyms
ADCAD2;
Chromosome
12
Map Location
12p13.2
Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Orthologs
View orthologs and multiple alignments for LRP6

Proteins

low-density lipoprotein receptor-related protein 6 precursor
Refseq ID NP_002327
Protein GI 148727288
UniProt ID O75581
mRNA ID NM_002336
Length 1613
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2024 peptide sequence: MGAVLRSLLACSFCVLLRA mat_peptide: 20..1613 product: low-density lipoprotein receptor-related protein 6 calculated_mol_wt: 178425 peptide sequence: APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS

Gene Information

Entrez Gene ID
4040
Gene Name
low density lipoprotein receptor-related protein 6
Gene Symbol
LRP6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:BHF-UCL C cell surface
GO:0031410 IDA:BHF-UCL C cytoplasmic vesicle
GO:0005769 IEA:Ensembl C early endosome
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043025 IBA:RefGenome C neuronal cell body
GO:0005886 IDA:BHF-UCL C plasma membrane
GO:0043235 IBA:RefGenome C receptor complex
GO:0045202 IBA:RefGenome C synapse
GO:0042813 IBA:RefGenome F Wnt-activated receptor activity
GO:0017147 IPI:BHF-UCL F Wnt-protein binding
GO:0034185 IBA:RefGenome F apolipoprotein binding
GO:0071936 IDA:BHF-UCL F coreceptor activity involved in Wnt signaling pathway
GO:0005109 IPI:BHF-UCL F frizzled binding
GO:0042802 IPI:IntAct F identical protein binding
GO:0019210 IMP:BHF-UCL F kinase inhibitor activity
GO:0005041 IDA:MGI F low-density lipoprotein receptor activity
GO:0042803 IPI:BHF-UCL F protein homodimerization activity
GO:0005102 IPI:BHF-UCL F receptor binding
GO:0019534 IMP:BHF-UCL F toxin transporter activity
GO:0016055 IMP:BHF-UCL P Wnt signaling pathway
GO:0044332 IDA:BHF-UCL P Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0021874 IEA:Ensembl P Wnt signaling pathway involved in forebrain neuroblast division
GO:0090244 IBA:RefGenome P Wnt signaling pathway involved in somitogenesis
GO:0009952 IBA:RefGenome P anterior/posterior pattern specification
GO:0090245 IBA:RefGenome P axis elongation involved in somitogenesis
GO:0060349 IBA:RefGenome P bone morphogenesis
GO:0046849 IBA:RefGenome P bone remodeling
GO:0060444 IBA:RefGenome P branching involved in mammary gland duct morphogenesis
GO:0060070 IDA:UniProtKB P canonical Wnt signaling pathway
GO:0061310 IEA:Ensembl P canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0044335 IC:BHF-UCL P canonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0061324 IEA:Ensembl P canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0044340 IC:BHF-UCL P canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0042074 IEA:Ensembl P cell migration involved in gastrulation
GO:0071397 IMP:BHF-UCL P cellular response to cholesterol
GO:0021587 IBA:RefGenome P cerebellum morphogenesis
GO:0021795 IEA:Ensembl P cerebral cortex cell migration
GO:0021987 IBA:RefGenome P cerebral cortex development
GO:0060026 IBA:RefGenome P convergent extension
GO:0071542 IEA:Ensembl P dopaminergic neuron differentiation
GO:0048596 IBA:RefGenome P embryonic camera-type eye morphogenesis
GO:0042733 IEA:Ensembl P embryonic digit morphogenesis
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0035116 IEA:Ensembl P embryonic hindlimb morphogenesis
GO:0030326 IBA:RefGenome P embryonic limb morphogenesis
GO:0009880 IBA:RefGenome P embryonic pattern specification
GO:0060059 IBA:RefGenome P embryonic retina morphogenesis in camera-type eye
GO:0035261 IBA:RefGenome P external genitalia morphogenesis
GO:0060325 IBA:RefGenome P face morphogenesis
GO:0021861 IEA:Ensembl P forebrain radial glial cell differentiation
GO:0021943 IEA:Ensembl P formation of radial glial scaffolds
GO:0001702 IBA:RefGenome P gastrulation with mouth forming second
GO:0001947 IEA:Ensembl P heart looping
GO:0060596 IEA:Ensembl P mammary placode formation
GO:0030901 IBA:RefGenome P midbrain development
GO:0030917 IBA:RefGenome P midbrain-hindbrain boundary development
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0045599 IEA:Ensembl P negative regulation of fat cell differentiation
GO:2000151 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000168 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in neural tube closure
GO:2000164 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000149 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0006469 IMP:BHF-UCL P negative regulation of protein kinase activity
GO:0001933 IMP:BHF-UCL P negative regulation of protein phosphorylation
GO:0071901 IDA:BHF-UCL P negative regulation of protein serine/threonine kinase activity
GO:0034392 IMP:BHF-UCL P negative regulation of smooth muscle cell apoptotic process
GO:0014033 IDA:BHF-UCL P neural crest cell differentiation
GO:0014029 IDA:BHF-UCL P neural crest formation
GO:0001843 IBA:RefGenome P neural tube closure
GO:0042475 IBA:RefGenome P odontogenesis of dentin-containing tooth
GO:0060021 IBA:RefGenome P palate development
GO:0003344 IBA:RefGenome P pericardium morphogenesis
GO:2000055 IDA:BHF-UCL P positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0045780 IEA:Ensembl P positive regulation of bone resorption
GO:0090263 IDA:BHF-UCL P positive regulation of canonical Wnt signaling pathway
GO:0045787 IMP:BHF-UCL P positive regulation of cell cycle
GO:0007204 IEA:Ensembl P positive regulation of cytosolic calcium ion concentration
GO:0002053 IEA:Ensembl P positive regulation of mesenchymal cell proliferation
GO:0045778 IEA:Ensembl P positive regulation of ossification
GO:0051091 IDA:BHF-UCL P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 IDA:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IMP:BHF-UCL P positive regulation of transcription, DNA-templated
GO:0036342 IEA:Ensembl P post-anal tail morphogenesis
GO:0090009 IBA:RefGenome P primitive streak formation
GO:0090118 IBA:RefGenome P receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0060284 IEA:Ensembl P regulation of cell development
GO:0045598 IBA:RefGenome P regulation of fat cell differentiation
GO:0030278 IBA:RefGenome P regulation of ossification
GO:0051593 IEA:Ensembl P response to folic acid
GO:0043434 IEA:Ensembl P response to peptide hormone
GO:0016337 IEA:Ensembl P single organismal cell-cell adhesion
GO:0007268 IBA:RefGenome P synaptic transmission
GO:0021794 IBA:RefGenome P thalamus development
GO:1901998 IMP:GOC P toxin transport
GO:0060535 IBA:RefGenome P trachea cartilage morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04310 Wnt signaling pathway
ko04310 Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116125 Disease
REACT_228188 RNF mutants show enhanced WNT signaling and proliferation
REACT_111102 Signal Transduction
REACT_228331 Signaling by WNT in cancer
REACT_11045 Signaling by Wnt
REACT_200777 TCF dependent signaling in response to WNT
REACT_228279 XAV939 inhibits tankyrase, stabilizing AXIN
REACT_200610 disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_228096 misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_200643 negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_200716 regulation of FZD by ubiquitination

Domain Information

InterPro Annotations

Accession Description
IPR000742 Epidermal growth factor-like domain
IPR000033 LDLR class B repeat
IPR017049 Low density lipoprotein receptor-related protein, 5/6
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
low density lipoprotein receptor-related protein 6
UniProt ID
O75581
Species
Human

Comments

Comment Type Description
Disease Coronary artery disease, autosomal dominant, 2 (ADCAD2) [MIM:610947]: A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction Note=The disease is caused by mutations affecting the gene represented in this entry.
Domain The PPPSP motifs play a central role in signal transduction by being phosphorylated, leading to activate the Wnt signaling pathway
Domain The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity)
Induction Decreased levels on WNT3A stimulation
Interaction Self; NbExp=2; IntAct=EBI-910915, EBI-910915; Q9Y4X0:AMMECR1; NbExp=5; IntAct=EBI-910915, EBI-8583355; Q9H6X2:ANTXR1; NbExp=3; IntAct=EBI-910915, EBI-905643; O35625:Axin1 (xeno); NbExp=2; IntAct=EBI-910915, EBI-2365912; O70239:Axin1 (xeno); NbExp=12; IntAct=EBI-910915, EBI-6857773; Q03135:CAV1; NbExp=3; IntAct=EBI-910915, EBI-603614; P98082:DAB2; NbExp=20; IntAct=EBI-910915, EBI-1171238; O94907:DKK1; NbExp=3; IntAct=EBI-910915, EBI-742864; Q61091:Fzd8 (xeno); NbExp=4; IntAct=EBI-910915, EBI-6171689; P49840:GSK3A; NbExp=2; IntAct=EBI-910915, EBI-1044067; P49841:GSK3B; NbExp=4; IntAct=EBI-910915, EBI-373586; Q5S007:LRRK2; NbExp=3; IntAct=EBI-910915, EBI-5323863; Q9ERE8:Mesdc1 (xeno); NbExp=2; IntAct=EBI-910915, EBI-6985232; P04426:Wnt1 (xeno); NbExp=2; IntAct=EBI-910915, EBI-1570911;
Ptm Dual phosphorylation of cytoplasmic PPPSP motifs sequentially by GSK3 and CK1 is required for AXIN1-binding, and subsequent stabilization and activation of beta-catenin via preventing GSK3- mediated phosphorylation of beta-catenin. Phosphorylated, in vitro, by GRK5/6 within and outside the PPPSP motifs. Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle. Phosphorylation by GSK3B is induced by RPSO1 binding and inhibited by DKK1. Phosphorylated, in vitro, by casein kinase I on Thr-1479. {ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:17569865, ECO:0000269|PubMed:17698587, ECO:0000269|PubMed:18362152, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20059949}.
Ptm Mono-ubiquitinated which retains LRP6 in the endoplasmic reticulum. Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:18378904, ECO:0000269|PubMed:22575959}.
Ptm N-glycosylation is required for cell surface location
Ptm Palmitoylation on the two sites near the transmembrane domain leads to release of LRP6 from the endoplasmic reticulum
Ptm Undergoes gamma-secretase-dependent regulated intramembrane proteolysis (RIP). The extracellular domain is first released by shedding, and then, through the action of gamma-secretase, the intracellular domain (ICD) is released into the cytoplasm where it is free to bind to GSK3B and to activate canonical Wnt signaling.
Similarity Belongs to the LDLR family
Similarity Contains 20 LDL-receptor class B repeats
Similarity Contains 3 LDL-receptor class A domains
Similarity Contains 4 EGF-like domains
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity)
Subunit Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Forms a WNT-signaling complex formed of a WNT protein, a FZD protein and LRP5 or LRP6. Interacts (via the extracellular domain) with WNT1; the interaction is enhanced by prior formation of the Wnt/Fzd complex. Interacts (via the beta-propeller regions 3 and 4) with WNT3A. Interacts (via the beta-propeller regions 1 and 2) with WNT9B. Interacts with FZD5; the interaction forms a coreceptor complex for Wnt signaling and is inhibited by DKK1 and DRAXIN. Interacts (via beta propeller region) with DKK1; the interaction inhibits FZD5/LRP6 complex formation. Interacts with DKK2. Interacts with C1orf187/DRAXIN; the interaction inhibits Wnt signaling (By similarity). Interacts (via the phosphorylated PPPSP motifs) with AXIN1; the interaction recruits the AXIN1/GSK3B complex to cell surface LRP6 signalsomes. Interacts with GRB10; the interaction prevents AXIN1 binding, thus negatively regulating the Wnt signaling pathway (By similarity). Interacts (via the extracellular domain) with RSPO1; the interaction activates Wnt/beta-catenin signaling. Interacts (via the extracellular domain) with RSPO3 (via the cysteine rich domain); the interaction activates Wnt/beta-catenin signaling. Interacts (via the beta- propeller regions 1 and 2) with SOST; the interaction competes with DKK1 for binding for inhibiting beta-catenin signaling. Interacts with MESD; the interaction prevents the formation of LRP6 aggregates and targets LRP6 to the plasma membrane (By similarity). Interacts (via the cytoplasmic domain) with CSNKIE; the interaction phosphorylates LRP6, binds AXIN1 and inhibits AXIN1/GSK3B-mediated phosphorylation of beta-catenin. Interacts with MACF1. Interacts with DAB2; the interaction involves LRP6 phosphorylation by CK2 and sequesters LRP6 towards clathrin- mediated endocytosis. Interacts with TMEM198. {ECO:0000250, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:12857724, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:15908424, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:16815997, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:17569865, ECO:0000269|PubMed:17698587, ECO:0000269|PubMed:18362152, ECO:0000269|PubMed:20093360, ECO:0000269|PubMed:21536646, ECO:0000269|PubMed:22000856, ECO:0000269|PubMed:22491013}.
Tissue Specificity Widely coexpressed with LRP5 during embryogenesis and in adult tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP012344 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148727288 RefSeq NP_002327 1613 low-density lipoprotein receptor-related protein 6 precursor

Identical Sequences to LMP012344 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012344 proteins

Reference Database Accession Length Protein Name