Gene/Proteome Database (LMPD)

LMPD ID
LMP012393
Gene ID
24208
Species
Rattus norvegicus (Rat)
Gene Name
androgen receptor
Gene Symbol
Ar
Synonyms
Tfm; Andr;
Alternate Names
androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4; androgen receptor (Testicular feminization), same as Tfm;
Chromosome
X
Map Location
Xq22-q32
Summary
binds androgens and activates transcription; required for male sexual development [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ar

Proteins

androgen receptor
Refseq ID NP_036634
Protein GI 6978535
UniProt ID P15207
mRNA ID NM_012502
Length 902
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQETSPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQQQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPSTGSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFSASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Gene Information

Entrez Gene ID
24208
Gene Name
androgen receptor
Gene Symbol
Ar
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:RGD C axon
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0030425 IDA:RGD C dendrite
GO:0000790 ISS:UniProtKB C nuclear chromatin
GO:0005634 ISS:UniProtKB C nucleus
GO:0005886 IEA:Ensembl C plasma membrane
GO:0003677 TAS:RGD F DNA binding
GO:0005497 IMP:RGD F androgen binding
GO:0004882 ISS:UniProtKB F androgen receptor activity
GO:0050681 IPI:RGD F androgen receptor binding
GO:0008013 ISS:UniProtKB F beta-catenin binding
GO:0004879 ISS:BHF-UCL F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0019904 IPI:RGD F protein domain specific binding
GO:0005102 IPI:UniProtKB F receptor binding
GO:0043565 IEA:Ensembl F sequence-specific DNA binding
GO:0003700 ISS:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0044212 ISS:UniProtKB F transcription regulatory region DNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0033327 IEA:Ensembl P Leydig cell differentiation
GO:0060520 IEA:Ensembl P activation of prostate induction by androgen receptor signaling pathway
GO:0030521 IMP:RGD P androgen receptor signaling pathway
GO:0071383 IEP:RGD P cellular response to steroid hormone stimulus
GO:0060742 IEA:Ensembl P epithelial cell differentiation involved in prostate gland development
GO:0003382 IEA:Ensembl P epithelial cell morphogenesis
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0030522 ISS:BHF-UCL P intracellular receptor signaling pathway
GO:0060599 IEA:Ensembl P lateral sprouting involved in mammary gland duct morphogenesis
GO:0048808 IEA:Ensembl P male genitalia morphogenesis
GO:0046661 IMP:RGD P male sex differentiation
GO:0019102 IEA:Ensembl P male somatic sex determination
GO:0060749 IEA:Ensembl P mammary gland alveolus development
GO:0060571 IEA:Ensembl P morphogenesis of an epithelial fold
GO:0035264 IEA:Ensembl P multicellular organism growth
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:2001237 ISS:BHF-UCL P negative regulation of extrinsic apoptotic signaling pathway
GO:0045720 ISS:UniProtKB P negative regulation of integrin biosynthetic process
GO:0048645 IEA:Ensembl P organ formation
GO:0043410 IEA:Ensembl P positive regulation of MAPK cascade
GO:0051092 ISS:UniProtKB P positive regulation of NF-kappaB transcription factor activity
GO:0008284 ISS:UniProtKB P positive regulation of cell proliferation
GO:0043568 IEA:Ensembl P positive regulation of insulin-like growth factor receptor signaling pathway
GO:0033148 IEA:Ensembl P positive regulation of intracellular estrogen receptor signaling pathway
GO:0042327 ISS:UniProtKB P positive regulation of phosphorylation
GO:0045944 ISS:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0060740 IEA:Ensembl P prostate gland epithelium morphogenesis
GO:0060736 IEA:Ensembl P prostate gland growth
GO:0050790 IEA:Ensembl P regulation of catalytic activity
GO:0048638 IEA:Ensembl P regulation of developmental growth
GO:0090003 ISS:UniProtKB P regulation of establishment of protein localization to plasma membrane
GO:0060685 IEA:Ensembl P regulation of prostatic bud formation
GO:0003073 IEA:Ensembl P regulation of systemic arterial blood pressure
GO:0032868 IEP:RGD P response to insulin
GO:0072520 IEA:Ensembl P seminiferous tubule development
GO:0007338 IEA:Ensembl P single fertilization
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0060748 IEA:Ensembl P tertiary branching involved in mammary gland duct morphogenesis
GO:0006351 ISS:UniProtKB P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ko04114 Oocyte meiosis
rno04114 Oocyte meiosis
rno05200 Pathways in cancer
ko05215 Prostate cancer
rno05215 Prostate cancer

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR001103 Androgen receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
androgen receptor
Protein Entry
ANDR_RAT
UniProt ID
P15207
Species
Rat

Comments

Comment Type Description
Disease Note=Defects in Ar are a cause of androgen insensitivity. Rats with this syndrome are called testicular feminized (TFM).
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N- terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity)
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity)
Miscellaneous In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
Miscellaneous Transcriptional activity is enhanced by binding to RANBP9.
Ptm Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity)
Ptm Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-517 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-61 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition (By similarity)
Ptm Sumoylated on Lys-384 (major) and Lys-503 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity)
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:9725910}. Cytoplasm . Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 (By similarity)
Subunit Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with GNB2L1/RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. {ECO:0000269|PubMed:11320241, ECO:0000269|PubMed:12350225, ECO:0000269|PubMed:15037741, ECO:0000269|PubMed:15603938, ECO:0000269|PubMed:17008401, ECO:0000269|PubMed:17181141, ECO:0000269|PubMed:9725910}.
Tissue Specificity Highest levels in the seminal vesicle, ventral prostate and coagulating gland with lower levels in the kidney and levator ani muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012393 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978535 RefSeq NP_036634 902 androgen receptor

Identical Sequences to LMP012393 proteins

Reference Database Accession Length Protein Name
GI:6978535 GenBank ABL23102.1 902 Sequence 21 from patent US 7129078
GI:6978535 GenBank AED74998.1 902 Sequence 6 from patent US 7910565
GI:6978535 GenBank AGV97423.1 902 Sequence 6 from patent US 8513210
GI:6978535 pat WO 902 Sequence 4 from Patent WO 8909791

Related Sequences to LMP012393 proteins

Reference Database Accession Length Protein Name
GI:6978535 GenBank AAA40733.1 902 androgen receptor [Rattus norvegicus]
GI:6978535 pat WO 902 Sequence 4 from Patent WO 8909791
GI:6978535 SwissProt P15207.1 902 RecName: Full=Androgen receptor; AltName: Full=Dihydrotestosterone receptor; AltName: Full=Nuclear receptor subfamily 3 group C member 4 [Rattus norvegicus]