Gene/Proteome Database (LMPD)

LMPD ID
LMP012399
Gene ID
24310
Species
Rattus norvegicus (Rat)
Gene Name
angiotensin I converting enzyme
Gene Symbol
Ace
Synonyms
Dcp1; StsRR92;
Alternate Names
angiotensin-converting enzyme; kininase II; dipeptidyl carboxypeptidase I; angiotensin 1 converting enzyme 1; angiotensin I converting enzyme 1; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1);
Chromosome
10
Map Location
10q32.1
EC Number
3.2.1.-
Summary
catalyzes the conversion of angiotensin I to angiotensin II; plays a role in regulation of blood pressure [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ace

Proteins

angiotensin-converting enzyme precursor
Refseq ID NP_036676
Protein GI 6978757
UniProt ID P47820
mRNA ID NM_012544
Length 1313
MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYNSSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTDQKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLDPELTNILASSRNYAKVLFAWEGWHDAVGIPLKPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQARVGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS
sig_peptide: 1..35 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3635 peptide sequence: MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPA mat_peptide: 36..1313 product: Angiotensin-converting enzyme experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P47820.1) calculated_mol_wt: 147263 peptide sequence: LDPGLQPGNFSADEAGAQLFADSYNSSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTDQKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLDPELTNILASSRNYAKVLFAWEGWHDAVGIPLKPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQARVGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS

Gene Information

Entrez Gene ID
24310
Gene Name
angiotensin I converting enzyme
Gene Symbol
Ace
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009925 IDA:RGD C basal plasma membrane
GO:0031526 IDA:RGD C brush border membrane
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005615 IDA:RGD C extracellular space
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:RGD C plasma membrane
GO:0031982 IDA:RGD C vesicle
GO:0004180 IEA:UniProtKB-KW F carboxypeptidase activity
GO:0008144 IPI:RGD F drug binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0008237 IDA:RGD F metallopeptidase activity
GO:0042277 IDA:RGD F peptide binding
GO:0008241 IDA:RGD F peptidyl-dipeptidase activity
GO:0007568 IEP:RGD P aging
GO:0060978 IMP:RGD P angiogenesis involved in coronary vascular morphogenesis
GO:0010815 IDA:RGD P bradykinin catabolic process
GO:0007420 IEP:RGD P brain development
GO:0071333 IEP:RGD P cellular response to glucose stimulus
GO:0042755 IMP:RGD P eating behavior
GO:0007565 IEP:RGD P female pregnancy
GO:0001822 IEP:RGD P kidney development
GO:0048286 IMP:RGD P lung alveolus development
GO:0030324 IEP:RGD P lung development
GO:0008584 IEP:RGD P male gonad development
GO:0090281 IMP:RGD P negative regulation of calcium ion import
GO:0031100 IMP:RGD P organ regeneration
GO:0043171 IDA:RGD P peptide catabolic process
GO:0006518 IMP:RGD P peptide metabolic process
GO:0043065 IMP:RGD P positive regulation of apoptotic process
GO:0050729 IMP:RGD P positive regulation of inflammatory response
GO:0050769 IMP:RGD P positive regulation of neurogenesis
GO:0003084 IMP:RGD P positive regulation of systemic arterial blood pressure
GO:0006508 IDA:RGD P proteolysis
GO:0008217 IDA:BHF-UCL P regulation of blood pressure
GO:0014910 IDA:BHF-UCL P regulation of smooth muscle cell migration
GO:0071548 IEP:RGD P response to dexamethasone
GO:0042493 IEP:RGD P response to drug
GO:0001666 IEP:RGD P response to hypoxia
GO:0034616 IEP:RGD P response to laminar fluid shear stress
GO:0032496 IMP:RGD P response to lipopolysaccharide
GO:0031667 IEP:RGD P response to nutrient levels
GO:0097066 IEP:RGD P response to thyroid hormone
GO:0019233 IMP:RGD P sensory perception of pain
GO:0042310 IMP:RGD P vasoconstriction

KEGG Pathway Links

KEGG Pathway ID Description
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko05410 Hypertrophic cardiomyopathy (HCM)
rno05410 Hypertrophic cardiomyopathy (HCM)
ko04614 Renin-angiotensin system
rno04614 Renin-angiotensin system

Domain Information

InterPro Annotations

Accession Description
IPR001548 Peptidase_M2

UniProt Annotations

Entry Information

Gene Name
angiotensin I converting enzyme
Protein Entry
ACE_RAT
UniProt ID
P47820
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Somatic; IsoId=P47820-1; Sequence=Displayed; Name=Testis-specific; Synonyms=ACE-T; IsoId=P47820-2, Q8CFN1-1; Sequence=VSP_037642, VSP_037643;
Catalytic Activity Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 2 Zn(2+) ions per subunit. Isoform Testis-specific only binds 1 Zn(2+) ion per subunit. ;
Cofactor Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence= ; Note=Binds 3 chloride ions per subunit. ;
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity)
Induction Up-regulated after myocardial infarction
Ptm Phosphorylated by CK2 on Ser-1306; which allows membrane retention
Similarity Belongs to the peptidase M2 family
Subcellular Location Angiotensin-converting enzyme, soluble form: Secreted .
Subcellular Location Cell membrane ; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm . Note=Detected in both cell membrane and cytoplasm in neurons
Tissue Specificity Testis-specific isoform is expressed in spermatocytes, adult testis. Also expressed in brain, kidney, lung, skeletal muscle and heart

Identical and Related Proteins

Unique RefSeq proteins for LMP012399 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978757 RefSeq NP_036676 1313 angiotensin-converting enzyme precursor

Identical Sequences to LMP012399 proteins

Reference Database Accession Length Protein Name
GI:6978757 GenBank AAA82111.1 1313 angiotensin converting enzyme [Rattus norvegicus]

Related Sequences to LMP012399 proteins

Reference Database Accession Length Protein Name
GI:6978757 GenBank AAA82111.1 1313 angiotensin converting enzyme [Rattus norvegicus]
GI:6978757 GenBank AAH85760.1 1313 Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Rattus norvegicus]
GI:6978757 GenBank EDM06348.1 1313 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, isoform CRA_a [Rattus norvegicus]