Gene/Proteome Database (LMPD)

LMPD ID
LMP012401
Gene ID
24326
Species
Rattus norvegicus (Rat)
Gene Name
endothelin receptor type A
Gene Symbol
Ednra
Synonyms
Eta; ET-A; ET-AR; Endor; RGD1559432;
Alternate Names
endothelin-1 receptor; endothelin A receptor;
Chromosome
19
Map Location
19q11
Summary
binds endothelin 1 and induces an increase in intracellular calcium [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ednra

Proteins

endothelin-1 receptor precursor
Refseq ID NP_036682
Protein GI 7549758
UniProt ID P26684
mRNA ID NM_012550
Length 426
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFDFLGTTLRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2040 peptide sequence: MGVLCFLASFWLALVGGAIA mat_peptide: 21..426 product: Endothelin-1 receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P26684.2) calculated_mol_wt: 46253 peptide sequence: DNAERYSANLSSHVEDFTPFPGTEFDFLGTTLRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN

Gene Information

Entrez Gene ID
24326
Gene Name
endothelin receptor type A
Gene Symbol
Ednra
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030315 IDA:RGD C T-tubule
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:RGD C membrane
GO:0031965 IDA:RGD C nuclear membrane
GO:0004962 IDA:RGD F endothelin receptor activity
GO:0007266 IMP:RGD P Rho protein signal transduction
GO:0007568 IEP:RGD P aging
GO:0014824 IEA:Ensembl P artery smooth muscle contraction
GO:0071260 IMP:RGD P cellular response to mechanical stimulus
GO:0086100 IDA:GOC P endothelin receptor signaling pathway
GO:0048484 IEA:InterPro P enteric nervous system development
GO:0048144 IMP:RGD P fibroblast proliferation
GO:0003094 IMP:RGD P glomerular filtration
GO:0015758 IEA:Ensembl P glucose transport
GO:0060322 IEA:Ensembl P head development
GO:0007507 IEA:Ensembl P heart development
GO:0001821 IMP:RGD P histamine secretion
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0060137 IEP:RGD P maternal process involved in parturition
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0030818 IEA:Ensembl P negative regulation of cAMP biosynthetic process
GO:0014032 IEA:Ensembl P neural crest cell development
GO:0001569 IEA:Ensembl P patterning of blood vessels
GO:0043084 IMP:RGD P penile erection
GO:0070374 IMP:RGD P positive regulation of ERK1 and ERK2 cascade
GO:0051928 IMP:RGD P positive regulation of calcium ion transport
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0007204 IDA:RGD P positive regulation of cytosolic calcium ion concentration
GO:0051482 IMP:RGD P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0050729 IMP:RGD P positive regulation of inflammatory response
GO:0090184 IMP:RGD P positive regulation of kidney development
GO:0090023 IMP:RGD P positive regulation of neutrophil chemotaxis
GO:0042482 IMP:RGD P positive regulation of odontogenesis
GO:0001934 IMP:RGD P positive regulation of protein phosphorylation
GO:0051281 IMP:RGD P positive regulation of release of sequestered calcium ion into cytosol
GO:0007205 IMP:RGD P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008217 IEA:InterPro P regulation of blood pressure
GO:0050678 IMP:RGD P regulation of epithelial cell proliferation
GO:0007585 IEA:Ensembl P respiratory gaseous exchange
GO:0001666 IEA:Ensembl P response to hypoxia
GO:0032496 IMP:RGD P response to lipopolysaccharide
GO:0043278 IMP:RGD P response to morphine
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0019233 IMP:RGD P sensory perception of pain
GO:0048659 IMP:RGD P smooth muscle cell proliferation
GO:0042310 IMP:RGD P vasoconstriction

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954121 Peptide ligand-binding receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR002175 Endothelin receptor A
IPR000499 Endothelin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
endothelin receptor type A
Protein Entry
EDNRA_RAT
UniProt ID
P26684
Species
Rat

Comments

Comment Type Description
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Similarity Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with HDAC7 and KAT5
Tissue Specificity Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.

Identical and Related Proteins

Unique RefSeq proteins for LMP012401 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7549758 RefSeq NP_036682 426 endothelin-1 receptor precursor

Identical Sequences to LMP012401 proteins

Reference Database Accession Length Protein Name
GI:7549758 GenBank AAA41114.1 426 endothelin receptor [Rattus norvegicus]
GI:7549758 RefSeq XP_006255482.1 426 PREDICTED: endothelin-1 receptor isoform X1 [Rattus norvegicus]
GI:7549758 RefSeq XP_008770693.1 426 PREDICTED: endothelin-1 receptor isoform X1 [Rattus norvegicus]

Related Sequences to LMP012401 proteins

Reference Database Accession Length Protein Name
GI:7549758 GenBank AAA41114.1 426 endothelin receptor [Rattus norvegicus]
GI:7549758 RefSeq XP_006255482.1 426 PREDICTED: endothelin-1 receptor isoform X1 [Rattus norvegicus]
GI:7549758 RefSeq XP_008770693.1 426 PREDICTED: endothelin-1 receptor isoform X1 [Rattus norvegicus]