Gene/Proteome Database (LMPD)

LMPD ID
LMP012418
Gene ID
24614
Species
Rattus norvegicus (Rat)
Gene Name
orosomucoid 1
Gene Symbol
Orm1
Synonyms
AGP; OMD; Orm; Agpa1;
Alternate Names
alpha-1-acid glycoprotein;
Chromosome
5
Map Location
5q24
Summary
an acute phase reactant protein; may have a role in the acute inflammation response [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Orm1

Proteins

alpha-1-acid glycoprotein precursor
Refseq ID NP_445740
Protein GI 16757980
UniProt ID P02764
mRNA ID NM_053288
Length 205
MALHMVLVVLSLLPLLEAQNPEPANITLGIPITNETLKWLSDKWFYMGAAFRDPVFKQAVQTIQTEYFYLTPNLINDTIELREFQTTDDQCVYNFTHLGVQRENGTLSKCAGAVKIFAHLIVLKKHGTFMLAFNLTDENRGLSFYAKKPDLSPELRKIFQQAVKDVGMDESEIVFVDWTKDKCSEQQKQQLELEKETKKETKKDP
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1963 peptide sequence: MALHMVLVVLSLLPLLEA mat_peptide: 19..205 product: alpha-1-acid glycoprotein calculated_mol_wt: 21631 peptide sequence: QNPEPANITLGIPITNETLKWLSDKWFYMGAAFRDPVFKQAVQTIQTEYFYLTPNLINDTIELREFQTTDDQCVYNFTHLGVQRENGTLSKCAGAVKIFAHLIVLKKHGTFMLAFNLTDENRGLSFYAKKPDLSPELRKIFQQAVKDVGMDESEIVFVDWTKDKCSEQQKQQLELEKETKKETKKDP

Gene Information

Entrez Gene ID
24614
Gene Name
orosomucoid 1
Gene Symbol
Orm1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0008144 IDA:RGD F drug binding
GO:0002438 IEP:RGD P acute inflammatory response to antigenic stimulus
GO:0006953 IEA:UniProtKB-KW P acute-phase response
GO:0071385 IEP:RGD P cellular response to glucocorticoid stimulus
GO:0071378 IEP:RGD P cellular response to growth hormone stimulus
GO:0071300 IEP:RGD P cellular response to retinoic acid
GO:0002439 IEP:RGD P chronic inflammatory response to antigenic stimulus
GO:0031100 IEP:RGD P organ regeneration
GO:0002682 IEA:InterPro P regulation of immune system process
GO:0042493 IEP:RGD P response to drug
GO:0032496 IEP:RGD P response to lipopolysaccharide
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0033197 IEP:RGD P response to vitamin E
GO:0006810 IEA:UniProtKB-KW P transport

Domain Information

InterPro Annotations

Accession Description
IPR001500 A1A_glycop
IPR012674 Calycin
IPR011038 Calycin-like
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
orosomucoid 1
Protein Entry
A1AG_RAT
UniProt ID
P02764
Species
Rat

Comments

Comment Type Description
Domain Contains a beta-barrel that binds various ligands in its interior
Function Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction
Induction Alpha-1-AGP is synthesized in the liver, the synthesis being controlled by glucocorticoids, interleukin-1 and interleukin-6, it increases 5- to 50-fold upon inflammation.
Similarity Belongs to the calycin superfamily. Lipocalin family
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP012418 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16757980 RefSeq NP_445740 205 alpha-1-acid glycoprotein precursor

Identical Sequences to LMP012418 proteins

Reference Database Accession Length Protein Name
GI:16757980 GenBank AAA40700.1 205 alpha-1-acid glycoprotein [Rattus norvegicus]
GI:16757980 GenBank AAA40701.1 205 alpha-1 acid glycoprotein [Rattus norvegicus]
GI:16757980 GenBank EDM10527.1 205 orosomucoid 1 [Rattus norvegicus]
GI:16757980 pat EP 205 Sequence 4 from Patent EP 0335654

Related Sequences to LMP012418 proteins

Reference Database Accession Length Protein Name
GI:16757980 GenBank AAA40699.1 205 alpha1-acid glycoprotein precursor [Rattus norvegicus]
GI:16757980 GenBank AAA40700.1 205 alpha-1-acid glycoprotein [Rattus norvegicus]
GI:16757980 SwissProt P02764.1 205 RecName: Full=Alpha-1-acid glycoprotein; AltName: Full=Orosomucoid; Short=OMD; Flags: Precursor [Rattus norvegicus]