Gene/Proteome Database (LMPD)

LMPD ID
LMP012421
Gene ID
24653
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Symbol
Pla2g4a
Synonyms
Pla2c; cPLA2; Pla2g4;
Alternate Names
cytosolic phospholipase A2; phospholipase A2 cytosolic; phospholipase A2 group IVA;
Chromosome
13
Map Location
13q21
Summary
catalyzes the synthesis of COX-2 substrate arachidonic acid (AA); may play a role in epileptogenesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pla2g4a

Proteins

cytosolic phospholipase A2
Refseq ID NP_598235
Protein GI 126722674
UniProt ID Q6IRF5
mRNA ID NM_133551
Length 752
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSTTLSSLKEKVSAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMTPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEDAEREYQNDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLRDFSPQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPTAESI

Gene Information

Entrez Gene ID
24653
Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Symbol
Pla2g4a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0005509 IEA:Ensembl F calcium ion binding
GO:0047498 IEA:Ensembl F calcium-dependent phospholipase A2 activity
GO:0005544 IEA:Ensembl F calcium-dependent phospholipid binding
GO:0050482 IEA:Ensembl P arachidonic acid secretion
GO:0071236 IEA:Ensembl P cellular response to antibiotic
GO:0046456 IEA:Ensembl P icosanoid biosynthetic process
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0042127 IEA:Ensembl P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04724 Glutamatergic synapse
rno04724 Glutamatergic synapse
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko04912 GnRH signaling pathway
rno04912 GnRH signaling pathway
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko00591 Linoleic acid metabolism
rno00591 Linoleic acid metabolism
ko04730 Long-term depression
rno04730 Long-term depression
ko04010 MAPK signaling pathway
rno04010 MAPK signaling pathway
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
rno04611 Platelet activation
rno04014 Ras signaling pathway
rno04726 Serotonergic synapse
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954238 ADP signalling through P2Y purinoceptor 1
5954472 Acyl chain remodeling of CL
5954464 Acyl chain remodelling of PC
5954471 Acyl chain remodelling of PE
5954465 Acyl chain remodelling of PG
5954468 Acyl chain remodelling of PI
5954470 Acyl chain remodelling of PS
5953493 Arachidonic acid metabolism
5953387 Ca-dependent events
5953389 G-protein mediated events
5953473 Glycerophospholipid biosynthesis
5953645 Hemostasis
5954469 Hydrolysis of LPC
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953390 Opioid Signalling
5953388 PLC beta mediated events
5953474 Phospholipid metabolism
5953644 Platelet activation, signaling and aggregation
5953658 Platelet homeostasis
5954271 Platelet sensitization by LDL
5953381 Signal Transduction
5954205 Signal amplification
5953391 Signaling by GPCR
5953472 Synthesis of PA
5953596 phospho-PLA2 pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Protein Entry
Q6IRF5_RAT
UniProt ID
Q6IRF5
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012421 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
126722674 RefSeq NP_598235 752 cytosolic phospholipase A2

Identical Sequences to LMP012421 proteins

Reference Database Accession Length Protein Name
GI:126722674 GenBank AAH70940.1 752 Phospholipase A2, group IVA (cytosolic, calcium-dependent) [Rattus norvegicus]
GI:126722674 GenBank EDM09590.1 752 phospholipase A2, group IVA (cytosolic, calcium-dependent) [Rattus norvegicus]
GI:126722674 GenBank AEU43310.1 752 Sequence 59 from patent US 8052970

Related Sequences to LMP012421 proteins

Reference Database Accession Length Protein Name
GI:126722674 GenBank AAH70940.1 752 Phospholipase A2, group IVA (cytosolic, calcium-dependent) [Rattus norvegicus]
GI:126722674 GenBank EDM09590.1 752 phospholipase A2, group IVA (cytosolic, calcium-dependent) [Rattus norvegicus]
GI:126722674 GenBank AEU43310.1 752 Sequence 59 from patent US 8052970