Gene/Proteome Database (LMPD)
LMPD ID
LMP012424
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
protein kinase, cAMP dependent regulatory, type II beta
Gene Symbol
Synonyms
RATDNA;
Alternate Names
cAMP-dependent protein kinase type II-beta regulatory subunit; Type II beta regulatory subunit of cAMP-dependent protein kinase;
Chromosome
6
Map Location
6q16
Summary
acts as a regulatory subunit of type II cAMP-dependent protein kinase [RGD, Feb 2006]
Orthologs
Proteins
| cAMP-dependent protein kinase type II-beta regulatory subunit | |
|---|---|
| Refseq ID | NP_001025191 |
| Protein GI | 158081759 |
| UniProt ID | P12369 |
| mRNA ID | NM_001030020 |
| Length | 416 |
| MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGTPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA | |
Gene Information
Entrez Gene ID
Gene Name
protein kinase, cAMP dependent regulatory, type II beta
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005952 | IDA:RGD | C | cAMP-dependent protein kinase complex |
| GO:0005737 | IDA:RGD | C | cytoplasm |
| GO:0043198 | ISS:ParkinsonsUK-UCL | C | dendritic shaft |
| GO:0043197 | ISS:ParkinsonsUK-UCL | C | dendritic spine |
| GO:0045121 | IDA:RGD | C | membrane raft |
| GO:0005743 | IDA:RGD | C | mitochondrial inner membrane |
| GO:0048471 | IDA:RGD | C | perinuclear region of cytoplasm |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0030552 | IDA:RGD | F | cAMP binding |
| GO:0008603 | IDA:RGD | F | cAMP-dependent protein kinase regulator activity |
| GO:0019904 | IMP:RGD | F | protein domain specific binding |
| GO:0034236 | IC:RGD | F | protein kinase A catalytic subunit binding |
| GO:0045859 | IDA:RGD | P | regulation of protein kinase activity |
| GO:0097332 | IEP:RGD | P | response to antipsychotic drug |
| GO:0097338 | IEP:RGD | P | response to clozapine |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000595 | Cyclic nucleotide-binding domain |
| IPR018488 | Cyclic nucleotide-binding, conserved site |
| IPR018490 | Cyclic nucleotide-binding-like |
| IPR003117 | Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit |
| IPR014710 | RmlC-like jelly roll fold |
| IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| IPR002373 | cAMP/cGMP-dependent protein kinase |
UniProt Annotations
Entry Information
Gene Name
protein kinase, cAMP dependent regulatory, type II beta
Protein Entry
KAP3_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| Interaction | Q5S007:LRRK2 (xeno); NbExp=3; IntAct=EBI-6096160, EBI-5323863; P17612:PRKACA (xeno); NbExp=2; IntAct=EBI-6096160, EBI-476586; |
| Ptm | Phosphorylated by the activated catalytic chain |
| Similarity | Belongs to the cAMP-dependent kinase regulatory chain family |
| Similarity | Contains 2 cyclic nucleotide-binding domains |
| Subcellular Location | Cytoplasm . Cell membrane . Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane |
| Subunit | The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2 (By similarity) |
| Tissue Specificity | Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Brain. Present in a few pyramidal neurons and mostly in mossy fibers. Colocalizes with PJA2 in dentate granule cells and at postsynaptic sites of primary hippocampal neurons |
Identical and Related Proteins
Unique RefSeq proteins for LMP012424 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 158081759 | RefSeq | NP_001025191 | 416 | cAMP-dependent protein kinase type II-beta regulatory subunit |
Identical Sequences to LMP012424 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:158081759 | GenBank | EDM03262.1 | 416 | protein kinase, cAMP dependent regulatory, type II beta, isoform CRA_a [Rattus norvegicus] |
| GI:158081759 | GenBank | EDM03263.1 | 416 | protein kinase, cAMP dependent regulatory, type II beta, isoform CRA_a [Rattus norvegicus] |
| GI:158081759 | SwissProt | P12369.3 | 416 | RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit [Rattus norvegicus] |
Related Sequences to LMP012424 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:158081759 | GenBank | EDM03262.1 | 416 | protein kinase, cAMP dependent regulatory, type II beta, isoform CRA_a [Rattus norvegicus] |
| GI:158081759 | GenBank | EDM03263.1 | 416 | protein kinase, cAMP dependent regulatory, type II beta, isoform CRA_a [Rattus norvegicus] |
| GI:158081759 | SwissProt | P12369.3 | 416 | RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit [Rattus norvegicus] |