Gene/Proteome Database (LMPD)
LMPD ID
LMP012426
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
protein kinase C, gamma
Gene Symbol
Synonyms
PKC; PKCI; Prkc; Prkcc; RATPKCI;
Alternate Names
protein kinase C gamma type; PKC-gamma; protein kinase C type I (gamma type);
Chromosome
1
Map Location
1q12
EC Number
2.7.11.13;
Summary
enriched in the neurons of the central nervous system and the spinal cord [RGD, Feb 2006]
Orthologs
Proteins
| protein kinase C gamma type | |
|---|---|
| Refseq ID | NP_036760 |
| Protein GI | 6981400 |
| UniProt ID | P63319 |
| mRNA ID | NM_012628 |
| Length | 697 |
| MAGLGPGGGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTSDEIHITVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDSKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIAPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005911 | IEA:Ensembl | C | cell-cell junction |
| GO:0005829 | IDA:UniProtKB | C | cytosol |
| GO:0030425 | IDA:UniProtKB | C | dendrite |
| GO:0043005 | IDA:RGD | C | neuron projection |
| GO:0005634 | IEA:Ensembl | C | nucleus |
| GO:0048471 | IDA:UniProtKB | C | perinuclear region of cytoplasm |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0097060 | IEA:Ensembl | C | synaptic membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0004698 | IDA:RGD | F | calcium-dependent protein kinase C activity |
| GO:0004697 | IDA:RGD | F | protein kinase C activity |
| GO:0004712 | IEA:Ensembl | F | protein serine/threonine/tyrosine kinase activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0007635 | IEA:Ensembl | P | chemosensory behavior |
| GO:0060384 | IEA:Ensembl | P | innervation |
| GO:0035556 | NAS:RGD | P | intracellular signal transduction |
| GO:0007611 | IEP:RGD | P | learning or memory |
| GO:0043524 | IMP:UniProtKB | P | negative regulation of neuron apoptotic process |
| GO:0042177 | IEA:Ensembl | P | negative regulation of protein catabolic process |
| GO:0031397 | IEA:Ensembl | P | negative regulation of protein ubiquitination |
| GO:0032425 | IEA:Ensembl | P | positive regulation of mismatch repair |
| GO:0046777 | IDA:RGD | P | protein autophosphorylation |
| GO:0043278 | ISS:UniProtKB | P | response to morphine |
| GO:0048265 | ISS:UniProtKB | P | response to pain |
| GO:0006950 | IDA:UniProtKB | P | response to stress |
| GO:0007268 | NAS:RGD | P | synaptic transmission |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko05143 | African trypanosomiasis |
| rno05143 | African trypanosomiasis |
| ko04960 | Aldosterone-regulated sodium reabsorption |
| rno04960 | Aldosterone-regulated sodium reabsorption |
| ko05146 | Amoebiasis |
| rno05146 | Amoebiasis |
| ko05031 | Amphetamine addiction |
| rno05031 | Amphetamine addiction |
| ko04020 | Calcium signaling pathway |
| rno04020 | Calcium signaling pathway |
| rno04725 | Cholinergic synapse |
| ko04713 | Circadian entrainment |
| rno04713 | Circadian entrainment |
| ko04728 | Dopaminergic synapse |
| rno04728 | Dopaminergic synapse |
| ko04961 | Endocrine and other factor-regulated calcium reabsorption |
| rno04961 | Endocrine and other factor-regulated calcium reabsorption |
| ko04012 | ErbB signaling pathway |
| rno04012 | ErbB signaling pathway |
| ko04664 | Fc epsilon RI signaling pathway |
| rno04664 | Fc epsilon RI signaling pathway |
| ko04666 | Fc gamma R-mediated phagocytosis |
| rno04666 | Fc gamma R-mediated phagocytosis |
| ko04510 | Focal adhesion |
| rno04510 | Focal adhesion |
| ko04727 | GABAergic synapse |
| rno04727 | GABAergic synapse |
| ko04540 | Gap junction |
| rno04540 | Gap junction |
| ko04971 | Gastric acid secretion |
| rno04971 | Gastric acid secretion |
| ko05214 | Glioma |
| rno05214 | Glioma |
| ko04724 | Glutamatergic synapse |
| rno04724 | Glutamatergic synapse |
| rno04066 | HIF-1 signaling pathway |
| rno05161 | Hepatitis B |
| ko04750 | Inflammatory mediator regulation of TRP channels |
| rno04750 | Inflammatory mediator regulation of TRP channels |
| rno04911 | Insulin secretion |
| ko04670 | Leukocyte transendothelial migration |
| rno04670 | Leukocyte transendothelial migration |
| ko04730 | Long-term depression |
| rno04730 | Long-term depression |
| ko04720 | Long-term potentiation |
| rno04720 | Long-term potentiation |
| ko04010 | MAPK signaling pathway |
| rno04010 | MAPK signaling pathway |
| ko04916 | Melanogenesis |
| rno04916 | Melanogenesis |
| ko05206 | MicroRNAs in cancer |
| rno05206 | MicroRNAs in cancer |
| ko05032 | Morphine addiction |
| rno05032 | Morphine addiction |
| ko04650 | Natural killer cell mediated cytotoxicity |
| rno04650 | Natural killer cell mediated cytotoxicity |
| ko05223 | Non-small cell lung cancer |
| rno05223 | Non-small cell lung cancer |
| ko04921 | Oxytocin signaling pathway |
| rno04921 | Oxytocin signaling pathway |
| ko04972 | Pancreatic secretion |
| rno04972 | Pancreatic secretion |
| rno05200 | Pathways in cancer |
| ko04070 | Phosphatidylinositol signaling system |
| rno04070 | Phosphatidylinositol signaling system |
| ko05205 | Proteoglycans in cancer |
| rno05205 | Proteoglycans in cancer |
| ko04015 | Rap1 signaling pathway |
| rno04015 | Rap1 signaling pathway |
| rno04014 | Ras signaling pathway |
| ko04723 | Retrograde endocannabinoid signaling |
| rno04723 | Retrograde endocannabinoid signaling |
| ko04970 | Salivary secretion |
| rno04970 | Salivary secretion |
| rno04726 | Serotonergic synapse |
| rno04919 | Thyroid hormone signaling pathway |
| ko04918 | Thyroid hormone synthesis |
| rno04918 | Thyroid hormone synthesis |
| ko04530 | Tight junction |
| rno04530 | Tight junction |
| ko04370 | VEGF signaling pathway |
| rno04370 | VEGF signaling pathway |
| ko04270 | Vascular smooth muscle contraction |
| rno04270 | Vascular smooth muscle contraction |
| ko04310 | Wnt signaling pathway |
| rno04310 | Wnt signaling pathway |
| ko04150 | mTOR signaling pathway |
| rno04150 | mTOR signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953387 | Ca-dependent events |
| 5953386 | CaM pathway |
| 5953598 | Calmodulin induced events |
| 5953392 | DAG and IP3 signaling |
| 5953408 | DAP12 interactions |
| 5953407 | DAP12 signaling |
| 5953253 | Disease |
| 5953652 | Disinhibition of SNARE formation |
| 5953396 | Downstream signal transduction |
| 5953399 | Downstream signaling of activated FGFR |
| 5953402 | EGFR interacts with phospholipase C-gamma |
| 5954206 | G alpha (z) signalling events |
| 5953389 | G-protein mediated events |
| 5953642 | GPCR downstream signaling |
| 5954212 | Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity |
| 5953645 | Hemostasis |
| 5953410 | Immune System |
| 5953409 | Innate Immune System |
| 5953394 | NGF signalling via TRKA from the plasma membrane |
| 5953277 | Neuronal System |
| 5953606 | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| 5953390 | Opioid Signalling |
| 5954628 | PCP/CE pathway |
| 5953388 | PLC beta mediated events |
| 5953393 | PLC-gamma1 signalling |
| 5953405 | PLCG1 events in ERBB2 signaling |
| 5953398 | Phospholipase C-mediated cascade |
| 5953644 | Platelet activation, signaling and aggregation |
| 5953646 | Response to elevated platelet cytosolic Ca2+ |
| 5953381 | Signal Transduction |
| 5953403 | Signaling by EGFR |
| 5953404 | Signaling by EGFR in Cancer |
| 5953406 | Signaling by ERBB2 |
| 5953400 | Signaling by FGFR |
| 5953401 | Signaling by FGFR in disease |
| 5953391 | Signaling by GPCR |
| 5953397 | Signaling by PDGF |
| 5953803 | Signaling by Wnt |
| 5953395 | Signalling by NGF |
| 5954228 | Trafficking of AMPA receptors |
| 5954229 | Trafficking of GluR2-containing AMPA receptors |
| 5953276 | Transmission across Chemical Synapses |
| 5954639 | WNT5A-dependent internalization of FZD4 |
| 5953802 | beta-catenin independent WNT signaling |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000961 | AGC-kinase, C-terminal |
| IPR000008 | C2 domain |
| IPR020454 | Diacylglycerol/phorbol-ester binding |
| IPR014375 | Protein kinase C, alpha/beta/gamma types |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| IPR000719 | Protein kinase domain |
| IPR017441 | Protein kinase, ATP binding site |
| IPR017892 | Protein kinase, C-terminal |
| IPR011009 | Protein kinase-like domain |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR002290 | Serine/threonine/dual specificity protein kinase, catalytic domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. ; |
| Enzyme Regulation | Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation. |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53- dependent apoptosis in response to DNA damage (By similarity) |
| Ptm | Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4 |
| Ptm | Ubiquitinated |
| Similarity | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily |
| Similarity | Contains 1 AGC-kinase C-terminal domain |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 protein kinase domain |
| Similarity | Contains 2 phorbol-ester/DAG-type zinc fingers |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, dendrite. Note=Translocates to synaptic membranes on stimulation. |
| Subunit | Interacts with CDCP1 (By similarity). Interacts with GRIA4. Interacts with TP53INP1 and p53/TP53 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012426 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6981400 | RefSeq | NP_036760 | 697 | protein kinase C gamma type |
Identical Sequences to LMP012426 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981400 | DBBJ | BAE25881.1 | 697 | unnamed protein product [Mus musculus] |
| GI:6981400 | GenBank | ABK42349.1 | 697 | protein kinase C gamma1 [synthetic construct] |
| GI:6981400 | GenBank | EDL31175.1 | 697 | protein kinase C, gamma [Mus musculus] |
| GI:6981400 | GenBank | EDL84948.1 | 697 | protein kinase C, gamma [Rattus norvegicus] |
Related Sequences to LMP012426 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981400 | EMBL | CAA30267.1 | 697 | unnamed protein product [Rattus rattus] |
| GI:6981400 | GenBank | AAA41874.1 | 697 | protein kinase C type II [Rattus norvegicus] |
| GI:6981400 | GenBank | AAA39939.1 | 697 | protein kinase C gamma [Mus musculus domesticus] |