Gene/Proteome Database (LMPD)

LMPD ID
LMP012460
Gene ID
25046
Species
Rattus norvegicus (Rat)
Gene Name
polymeric immunoglobulin receptor
Gene Symbol
Pigr
Synonyms
pIgA-R; RNPIGR2;
Alternate Names
polymeric immunoglobulin receptor; poly-Ig receptor; polymeric IgA receptor;
Chromosome
13
Map Location
13q13
Summary
contains a trinucleotide repeat-rich fragment in the 3' untranslated region that may regulate gene expression [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pigr

Proteins

polymeric immunoglobulin receptor precursor
Refseq ID NP_036855
Protein GI 501354879
UniProt ID P15083
mRNA ID NM_012723
Length 769
MRLSLFALLVTVFSGVSTQSPIFGPQDVSSIEGNSVSITCYYPDTSVNRHTRKYWCRQGANGYCATLISSNGYLSKEYSGRASLINFPENSTFVINIAHLTQEDTGSYKCGLGTTNRGLFFDVSLEVSQVPEFPNDTHVYTKDIGRTVTIECRFKEGNAHSKKSLCKKRGEACEVVIDSTEYVDPSYKDRAILFMKGTSRDIFYVNISHLIPSDAGLYVCQAGEGPSADKNNADLQVLEPEPELLYKDLRSSVTFECDLGREVANDAKYLCRKNKETCDVIINTLGKRDPAFEGRILLTPRDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPVQAWQLFVNEESTIPNSRSVVKGVTGGSVAIVCPYNPKESSSLKYWCHWEADENGRCPVLVGTQALVQEGYEGRLALFDQPGSGAYTVILNQLTTQDSGFYWCLTDGDSRWRTTIELQVAEATKKPDLEVTPQNATAVIGETFTISCHYPCKFYSQEKYWCKWSNDGCHILPSHDEGARQSSVSCDQSSQIVSMTLNPVKKEDEGWYWCGVKEGQVYGETTAIYVAVEERTRGSPHINPTDANARAKDAPEEEAMESSVREDENKANLDPRLFADEREIQNAGDQAQENRASGNAGSAGGQSGSSKVLFSTLVPLGLVLAVGAVAVWVARVRHRKNVDRMSISSYRTDISMGDFRNSRDLGGNDNMGATPDTQETVLEGKDEIETTTECTTEPEESKKAKRSSKEEADMAYSAFLFQSSTIAAQVHDGPQEA
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1941 peptide sequence: MRLSLFALLVTVFSGVST mat_peptide: 19..769 product: Polymeric immunoglobulin receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P15083.1) calculated_mol_wt: 82875 peptide sequence: QSPIFGPQDVSSIEGNSVSITCYYPDTSVNRHTRKYWCRQGANGYCATLISSNGYLSKEYSGRASLINFPENSTFVINIAHLTQEDTGSYKCGLGTTNRGLFFDVSLEVSQVPEFPNDTHVYTKDIGRTVTIECRFKEGNAHSKKSLCKKRGEACEVVIDSTEYVDPSYKDRAILFMKGTSRDIFYVNISHLIPSDAGLYVCQAGEGPSADKNNADLQVLEPEPELLYKDLRSSVTFECDLGREVANDAKYLCRKNKETCDVIINTLGKRDPAFEGRILLTPRDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPVQAWQLFVNEESTIPNSRSVVKGVTGGSVAIVCPYNPKESSSLKYWCHWEADENGRCPVLVGTQALVQEGYEGRLALFDQPGSGAYTVILNQLTTQDSGFYWCLTDGDSRWRTTIELQVAEATKKPDLEVTPQNATAVIGETFTISCHYPCKFYSQEKYWCKWSNDGCHILPSHDEGARQSSVSCDQSSQIVSMTLNPVKKEDEGWYWCGVKEGQVYGETTAIYVAVEERTRGSPHINPTDANARAKDAPEEEAMESSVREDENKANLDPRLFADEREIQNAGDQAQENRASGNAGSAGGQSGSSKVLFSTLVPLGLVLAVGAVAVWVARVRHRKNVDRMSISSYRTDISMGDFRNSRDLGGNDNMGATPDTQETVLEGKDEIETTTECTTEPEESKKAKRSSKEEADMAYSAFLFQSSTIAAQVHDGPQEA

Gene Information

Entrez Gene ID
25046
Gene Name
polymeric immunoglobulin receptor
Gene Symbol
Pigr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0055038 IDA:RGD C recycling endosome membrane
GO:0030133 IDA:RGD C transport vesicle
GO:0005154 IPI:RGD F epidermal growth factor receptor binding

KEGG Pathway Links

KEGG Pathway ID Description
ko04672 Intestinal immune network for IgA production
rno04672 Intestinal immune network for IgA production

Domain Information

InterPro Annotations

Accession Description
IPR013106 Immunoglobulin V-set domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold

UniProt Annotations

Entry Information

Gene Name
polymeric immunoglobulin receptor
Protein Entry
PIGR_RAT
UniProt ID
P15083
Species
Rat

Comments

Comment Type Description
Function This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Similarity Contains 5 Ig-like V-type (immunoglobulin-like) domains
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Subcellular Location Secretory component: Secreted.

Identical and Related Proteins

Unique RefSeq proteins for LMP012460 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
501354879 RefSeq NP_036855 769 polymeric immunoglobulin receptor precursor

Identical Sequences to LMP012460 proteins

Reference Database Accession Length Protein Name
GI:501354879 GenBank AAW11608.1 769 Sequence 10 from patent US 6808709
GI:501354879 GenBank AAY01385.1 769 Sequence 3 from patent US 6855810
GI:501354879 GenBank ABT01733.1 769 Sequence 10 from patent US 7211389
GI:501354879 GenBank ACH17900.1 769 Sequence 3 from patent US 7404954

Related Sequences to LMP012460 proteins

Reference Database Accession Length Protein Name
GI:501354879 GenBank AAE83443.1 769 Sequence 10 from patent US 6303341
GI:501354879 GenBank ACH17900.1 769 Sequence 3 from patent US 7404954
GI:501354879 SwissProt P15083.1 769 RecName: Full=Polymeric immunoglobulin receptor; Short=PIgR; Short=Poly-Ig receptor; Contains: RecName: Full=Secretory component; Flags: Precursor [Rattus norvegicus]