Gene/Proteome Database (LMPD)

LMPD ID
LMP012477
Gene ID
25149
Species
Rattus norvegicus (Rat)
Gene Name
estrogen receptor 2 (ER beta)
Gene Symbol
Esr2
Synonyms
Erb2; ERbeta; ER-beta;
Alternate Names
estrogen receptor beta; estrogen receptor 2 beta; nuclear receptor subfamily 3 group A member 2;
Chromosome
6
Map Location
6q24
Summary
binds estrogen and mediates transcriptional activation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Esr2

Proteins

estrogen receptor beta
Refseq ID NP_036886
Protein GI 6978817
UniProt ID Q62986
mRNA ID NM_012754
Length 485
MTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ

Gene Information

Entrez Gene ID
25149
Gene Name
estrogen receptor 2 (ER beta)
Gene Symbol
Esr2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005929 IDA:RGD C cilium
GO:0005737 IDA:RGD C cytoplasm
GO:0005739 IDA:MGI C mitochondrion
GO:0043005 IDA:RGD C neuron projection
GO:0043025 IDA:RGD C neuronal cell body
GO:0005634 IDA:RGD C nucleus
GO:0043204 IDA:RGD C perikaryon
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0005886 IDA:RGD C plasma membrane
GO:0032993 IDA:RGD C protein-DNA complex
GO:0000978 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001046 IDA:RGD F core promoter sequence-specific DNA binding
GO:0008144 IPI:RGD F drug binding
GO:0019899 IPI:RGD F enzyme binding
GO:0030284 IDA:RGD F estrogen receptor activity
GO:0034056 IDA:RGD F estrogen response element binding
GO:0042562 IDA:RGD F hormone binding
GO:0042975 IPI:RGD F peroxisome proliferator activated receptor binding
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0005496 IDA:UniProtKB F steroid binding
GO:1990239 IPI:RGD F steroid hormone binding
GO:0003707 IDA:RGD F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0060009 IEP:RGD P Sertoli cell development
GO:0060011 IMP:RGD P Sertoli cell proliferation
GO:0021764 IEP:RGD P amygdala development
GO:0001662 IDA:RGD P behavioral fear response
GO:0035690 IEP:RGD P cellular response to drug
GO:0071392 IEP:RGD P cellular response to estradiol stimulus
GO:0071259 IEP:RGD P cellular response to magnetism
GO:0071407 IEP:RGD P cellular response to organic cyclic compound
GO:0021549 IEP:RGD P cerebellum development
GO:0060209 IMP:RGD P estrus
GO:0008585 IEP:RGD P female gonad development
GO:0021854 IEP:RGD P hypothalamus development
GO:0030520 TAS:RGD P intracellular estrogen receptor signaling pathway
GO:0030518 IDA:RGD P intracellular steroid hormone receptor signaling pathway
GO:0007611 IMP:RGD P learning or memory
GO:0008584 IEP:RGD P male gonad development
GO:0048521 IDA:RGD P negative regulation of behavior
GO:0060548 IMP:RGD P negative regulation of cell death
GO:0050680 IDA:RGD P negative regulation of epithelial cell proliferation
GO:2000252 IMP:RGD P negative regulation of feeding behavior
GO:1901215 IDA:RGD P negative regulation of neuron death
GO:2000378 IMP:RGD P negative regulation of reactive oxygen species metabolic process
GO:0048662 IMP:RGD P negative regulation of smooth muscle cell proliferation
GO:0000122 IDA:RGD P negative regulation of transcription from RNA polymerase II promoter
GO:0001541 IEP:RGD P ovarian follicle development
GO:0070374 IDA:RGD P positive regulation of ERK1 and ERK2 cascade
GO:0043065 IDA:RGD P positive regulation of apoptotic process
GO:0045742 IMP:RGD P positive regulation of epidermal growth factor receptor signaling pathway
GO:0051091 ISS:UniProtKB P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IDA:RGD P positive regulation of transcription, DNA-templated
GO:0030850 IEP:RGD P prostate gland development
GO:0043523 IDA:RGD P regulation of neuron apoptotic process
GO:0014823 IEP:RGD P response to activity
GO:0071548 IEP:RGD P response to dexamethasone
GO:0042493 IEP:RGD P response to drug
GO:0032355 IEP:RGD P response to estradiol
GO:0043627 IEP:RGD P response to estrogen
GO:0045471 IEP:RGD P response to ethanol
GO:0033595 IEP:RGD P response to genistein
GO:0009725 IEP:RGD P response to hormone
GO:0044752 IEP:RGD P response to human chorionic gonadotropin
GO:0017085 IEP:RGD P response to insecticide
GO:0031667 IEP:RGD P response to nutrient levels
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:1902074 IEP:RGD P response to salt
GO:0033574 IMP:RGD P response to testosterone
GO:0009414 IEP:RGD P response to water deprivation

KEGG Pathway Links

KEGG Pathway ID Description
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR021064 Estrogen receptor beta, N-terminal
IPR028355 Estrogen receptor beta/gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR024178 Oestrogen receptor/oestrogen-related receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
estrogen receptor 2 (ER beta)
Protein Entry
ESR2_RAT
UniProt ID
Q62986
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Beta1; IsoId=Q62986-1; Sequence=Displayed; Name=2; Synonyms=Beta2; IsoId=Q62986-2; Sequence=VSP_003699; Name=3; Synonyms=Beta1-delta3; IsoId=Q62986-3; Sequence=VSP_003697; Name=4; Synonyms=Beta2-delta3; IsoId=Q62986-4; Sequence=VSP_003697, VSP_003699; Name=5; Synonyms=Beta1-delta4; IsoId=Q62986-5; Sequence=VSP_003698;
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Binds estrogens with an affinity similar to that of ER- alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER- alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
Ptm Phosphorylation at Ser-87 and Ser-105 recruits NCOA1
Sequence Caution Sequence=CAA05631.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus.
Subunit Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with PRMT2 (By similarity). Interacts with DYX1C1. {ECO:0000250, ECO:0000269|PubMed:11818503, ECO:0000269|PubMed:19423554}.
Tissue Specificity Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis.

Identical and Related Proteins

Unique RefSeq proteins for LMP012477 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978817 RefSeq NP_036886 485 estrogen receptor beta

Identical Sequences to LMP012477 proteins

Reference Database Accession Length Protein Name
GI:6978817 GenBank AAC52602.1 485 estrogen receptor beta [Rattus norvegicus]
GI:6978817 GenBank AAE28185.1 485 Sequence 2 from patent US 5958710
GI:6978817 GenBank ABL29591.1 485 Sequence 2 from patent US 7132261

Related Sequences to LMP012477 proteins

Reference Database Accession Length Protein Name
GI:6978817 GenBank AAC52602.1 485 estrogen receptor beta [Rattus norvegicus]
GI:6978817 GenBank AAE28185.1 485 Sequence 2 from patent US 5958710
GI:6978817 GenBank ABL29591.1 485 Sequence 2 from patent US 7132261