Gene/Proteome Database (LMPD)

LMPD ID
LMP012502
Gene ID
25344
Species
Rattus norvegicus (Rat)
Gene Name
prohibitin
Gene Symbol
Phb
Alternate Names
prohibitin;
Chromosome
10
Map Location
chromosome:10
Summary
inhibits entry into S phase of the mitotic cell cycle; involved in negative regulation of cell proliferation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Phb

Proteins

prohibitin
Refseq ID NP_114039
Protein GI 13937353
UniProt ID P67779
mRNA ID NM_031851
Length 272
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ

Gene Information

Entrez Gene ID
25344
Gene Name
prohibitin
Gene Symbol
Phb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0031315 IDA:RGD C extrinsic component of mitochondrial outer membrane
GO:0030061 IDA:RGD C mitochondrial crista
GO:0005739 IDA:RGD C mitochondrion
GO:0005634 IDA:RGD C nucleus
GO:0006260 IEA:UniProtKB-KW P DNA replication
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0008285 IMP:RGD P negative regulation of cell proliferation
GO:0031100 IEP:RGD P organ regeneration
GO:0001552 IEP:RGD P ovarian follicle atresia
GO:0001541 IEP:RGD P ovarian follicle development
GO:0034097 IEP:RGD P response to cytokine
GO:0042493 IEP:RGD P response to drug
GO:0045471 IEP:RGD P response to ethanol
GO:0035902 IEP:RGD P response to immobilization stress
GO:0043434 IEP:RGD P response to peptide hormone

Domain Information

InterPro Annotations

Accession Description
IPR001107 Band 7 protein
IPR000163 Prohibitin

UniProt Annotations

Entry Information

Gene Name
prohibitin
Protein Entry
PHB_RAT
UniProt ID
P67779
Species
Rat

Comments

Comment Type Description
Developmental Stage Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas
Function Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Similarity Belongs to the prohibitin family
Subcellular Location Mitochondrion inner membrane .
Subunit Interacts with PHB2. Interacts with STOML2 (By similarity)
Tissue Specificity Expressed in brain, heart, intestine, kidney, liver, skeletal muscle. Highest levels in heart, liver, kidney and intestine. Also expressed in flagella of epididymal sperm

Identical and Related Proteins

Unique RefSeq proteins for LMP012502 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13937353 RefSeq NP_114039 272 prohibitin

Identical Sequences to LMP012502 proteins

Reference Database Accession Length Protein Name
GI:13937353 RefSeq XP_005075923.1 272 PREDICTED: prohibitin [Mesocricetus auratus]
GI:13937353 RefSeq XP_006924839.1 272 PREDICTED: prohibitin [Pteropus alecto]
GI:13937353 RefSeq XP_007642664.1 272 PREDICTED: prohibitin [Cricetulus griseus]
GI:13937353 RefSeq XP_007642665.1 272 PREDICTED: prohibitin [Cricetulus griseus]

Related Sequences to LMP012502 proteins

Reference Database Accession Length Protein Name
GI:13937353 DBBJ BAB27067.1 272 unnamed protein product [Mus musculus]
GI:13937353 GenBank AAH97304.1 272 Prohibitin [Rattus norvegicus]
GI:13937353 RefSeq XP_006924839.1 272 PREDICTED: prohibitin [Pteropus alecto]