Gene/Proteome Database (LMPD)

LMPD ID
LMP012514
Gene ID
25511
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylethanolamine N-methyltransferase
Gene Symbol
Pemt
Synonyms
Pempt; PHOMETH;
Alternate Names
phosphatidylethanolamine N-methyltransferase; PEAMT;
Chromosome
10
Map Location
10q22
EC Number
2.1.1.17
Summary
catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pemt

Proteins

phosphatidylethanolamine N-methyltransferase
Refseq ID NP_037135
Protein GI 6981348
UniProt ID Q08388
mRNA ID NM_013003
Length 199
MSWLLGYVDPTEPSFVAAVLTIVFNPLFWNVVARWEQRTRKLSRAFGSPYLACYSLGSIILLLNILRSHCFTQAMMSQPKMEGLDSHTIYFLGLALLGWGLVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVALVYVVALLFEEPFTAEIYRRKATRLHKRS

Gene Information

Entrez Gene ID
25511
Gene Name
phosphatidylethanolamine N-methyltransferase
Gene Symbol
Pemt
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031526 IDA:RGD C brush border membrane
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:RGD C membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0042383 IDA:RGD C sarcolemma
GO:0008429 IDA:RGD F phosphatidylethanolamine binding
GO:0004608 IDA:RGD F phosphatidylethanolamine N-methyltransferase activity
GO:0080101 IEA:UniProtKB-EC F phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO:0000773 IEA:UniProtKB-EC F phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0008757 IDA:RGD F S-adenosylmethionine-dependent methyltransferase activity
GO:0006650 IMP:RGD P glycerophospholipid metabolic process
GO:0008285 IMP:RGD P negative regulation of cell proliferation
GO:0006656 IDA:RGD P phosphatidylcholine biosynthetic process
GO:0050747 IMP:RGD P positive regulation of lipoprotein metabolic process
GO:0043200 IEP:RGD P response to amino acid
GO:0042493 IDA:RGD P response to drug
GO:0045471 IEP:RGD P response to ethanol
GO:0007584 IEP:RGD P response to nutrient
GO:0033273 IDA:RGD P response to vitamin
GO:0046498 IDA:RGD P S-adenosylhomocysteine metabolic process
GO:0046500 IDA:RGD P S-adenosylmethionine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6825 phosphatidylcholine biosynthesis V

Domain Information

InterPro Annotations

Accession Description
IPR024960 Phosphatidyl-N-methylethanolamine/N-methyltransferase
IPR007318 Phospholipid methyltransferase

UniProt Annotations

Entry Information

Gene Name
phosphatidylethanolamine N-methyltransferase
Protein Entry
PEMT_RAT
UniProt ID
Q08388
Species
Rat

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. {ECO:0000255|PROSITE- ProRule:PRU00931}.
Catalytic Activity S-adenosyl-L-methionine + phosphatidyl-N- dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine
Catalytic Activity S-adenosyl-L-methionine + phosphatidyl-N- methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N- dimethylethanolamine
Function Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein .
Tissue Specificity Liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012514 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981348 RefSeq NP_037135 199 phosphatidylethanolamine N-methyltransferase

Identical Sequences to LMP012514 proteins

Reference Database Accession Length Protein Name
GI:6981348 GenBank AAA03154.1 199 phosphatidylethanolamine N-methyltransferase [Rattus norvegicus]
GI:6981348 GenBank AAH91162.1 199 Phosphatidylethanolamine N-methyltransferase [Rattus norvegicus]
GI:6981348 SwissProt Q08388.2 199 RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PEAMT; Short=PEMT [Rattus norvegicus]

Related Sequences to LMP012514 proteins

Reference Database Accession Length Protein Name
GI:6981348 GenBank AAA03154.1 199 phosphatidylethanolamine N-methyltransferase [Rattus norvegicus]
GI:6981348 GenBank AAH91162.1 199 Phosphatidylethanolamine N-methyltransferase [Rattus norvegicus]
GI:6981348 SwissProt Q08388.2 199 RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PEAMT; Short=PEMT [Rattus norvegicus]