Gene/Proteome Database (LMPD)

LMPD ID
LMP012541
Gene ID
25664
Species
Rattus norvegicus (Rat)
Gene Name
peroxisome proliferator-activated receptor gamma
Gene Symbol
Pparg
Alternate Names
peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activated receptor gamma; peroxisome proliferator activator receptor, gamma;
Chromosome
4
Map Location
4q42
Summary
ligand-activated transcription factor; mediates expression of genes involved in lipid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pparg

Proteins

peroxisome proliferator-activated receptor gamma isoform 1
Refseq ID NP_037256
Protein GI 6981386
UniProt ID O88275
mRNA ID NM_013124
Length 505
MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
peroxisome proliferator-activated receptor gamma isoform 2
Refseq ID NP_001138838
Protein GI 223941854
UniProt ID O88275
mRNA ID NM_001145366
Length 475
MVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
peroxisome proliferator-activated receptor gamma isoform 2
Refseq ID NP_001138839
Protein GI 223941857
UniProt ID O88275
mRNA ID NM_001145367
Length 475
Protein sequence is identical to GI:223941854 (mRNA isoform)

Gene Information

Entrez Gene ID
25664
Gene Name
peroxisome proliferator-activated receptor gamma
Gene Symbol
Pparg
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0005634 IDA:RGD C nucleus
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0003677 IDA:RGD F DNA binding
GO:0001012 IEA:Ensembl F RNA polymerase II regulatory region DNA binding
GO:0001228 IEA:Ensembl F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682 ISS:UniProtKB F chromatin binding
GO:0008144 IEA:Ensembl F drug binding
GO:0030331 IPI:RGD F estrogen receptor binding
GO:0004879 IEA:InterPro F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0030374 ISS:UniProtKB F ligand-dependent nuclear receptor transcription coactivator activity
GO:0019903 IDA:RGD F protein phosphatase binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IDA:BHF-UCL F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008134 IPI:RGD F transcription factor binding
GO:0044212 IDA:BHF-UCL F transcription regulatory region DNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006919 IEA:Ensembl P activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050873 IEA:Ensembl P brown fat cell differentiation
GO:0045165 IEA:Ensembl P cell fate commitment
GO:0048469 IEA:Ensembl P cell maturation
GO:0071455 IEP:RGD P cellular response to hyperoxia
GO:0032869 IEA:Ensembl P cellular response to insulin stimulus
GO:0071285 IEA:Ensembl P cellular response to lithium ion
GO:0071380 IEP:RGD P cellular response to prostaglandin E stimulus
GO:0071379 IEP:RGD P cellular response to prostaglandin stimulus
GO:0071300 IEP:RGD P cellular response to retinoic acid
GO:0071306 IEP:RGD P cellular response to vitamin E
GO:0030855 IEA:Ensembl P epithelial cell differentiation
GO:0006631 TAS:RGD P fatty acid metabolic process
GO:0019395 IMP:RGD P fatty acid oxidation
GO:0042593 IEA:Ensembl P glucose homeostasis
GO:0007507 IEP:RGD P heart development
GO:0042953 IEA:Ensembl P lipoprotein transport
GO:0015909 IEA:Ensembl P long-chain fatty acid transport
GO:0045713 IEA:Ensembl P low-density lipoprotein particle receptor biosynthetic process
GO:0030224 IEA:Ensembl P monocyte differentiation
GO:0002674 IMP:RGD P negative regulation of acute inflammatory response
GO:0030308 IMP:RGD P negative regulation of cell growth
GO:0008285 IMP:RGD P negative regulation of cell proliferation
GO:0010887 IEA:Ensembl P negative regulation of cholesterol storage
GO:0032966 IMP:RGD P negative regulation of collagen biosynthetic process
GO:0060336 IEA:Ensembl P negative regulation of interferon-gamma-mediated signaling pathway
GO:2000230 IMP:RGD P negative regulation of pancreatic stellate cell proliferation
GO:0010871 IEA:Ensembl P negative regulation of receptor biosynthetic process
GO:0010891 IEA:Ensembl P negative regulation of sequestering of triglyceride
GO:0048662 IEA:Ensembl P negative regulation of smooth muscle cell proliferation
GO:0051974 IMP:RGD P negative regulation of telomerase activity
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0031100 IEP:RGD P organ regeneration
GO:0035357 IEA:Ensembl P peroxisome proliferator activated receptor signaling pathway
GO:0001890 IEA:Ensembl P placenta development
GO:0043065 IMP:RGD P positive regulation of apoptotic process
GO:0045600 ISS:HGNC P positive regulation of fat cell differentiation
GO:0046321 IMP:RGD P positive regulation of fatty acid oxidation
GO:0048714 IMP:RGD P positive regulation of oligodendrocyte differentiation
GO:0060100 IMP:RGD P positive regulation of phagocytosis, engulfment
GO:0051091 IEA:Ensembl P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 IDA:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0008217 IEA:Ensembl P regulation of blood pressure
GO:0045598 IDA:RGD P regulation of fat cell differentiation
GO:0019216 IMP:RGD P regulation of lipid metabolic process
GO:0006357 IMP:RGD P regulation of transcription from RNA polymerase II promoter
GO:0060850 ISS:UniProtKB P regulation of transcription involved in cell fate commitment
GO:0031000 IEP:RGD P response to caffeine
GO:0009409 IEP:RGD P response to cold
GO:0036270 IEP:RGD P response to diuretic
GO:0042493 IEP:RGD P response to drug
GO:0043627 IEP:RGD P response to estrogen
GO:0035902 IEP:RGD P response to immobilization stress
GO:0033993 IEP:RGD P response to lipid
GO:0055098 IEA:Ensembl P response to low-density lipoprotein particle
GO:0009612 IEP:RGD P response to mechanical stimulus
GO:1901558 IEP:RGD P response to metformin
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010033 IEP:RGD P response to organic substance
GO:0032526 ISS:UniProtKB P response to retinoic acid
GO:0042594 IEP:RGD P response to starvation
GO:0033189 IEP:RGD P response to vitamin A
GO:0050872 ISS:HGNC P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko05016 Huntington's disease
rno05016 Huntington's disease
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
rno05200 Pathways in cancer
ko05216 Thyroid cancer
rno05216 Thyroid cancer
ko05202 Transcriptional misregulation in cancer
rno05202 Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID Description
5953533 Developmental Biology
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953330 Gene Expression
5953833 Generic Transcription Pathway
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954147 Nuclear Receptor transcription pathway
5954333 PPARA activates gene expression
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954166 Transcriptional regulation of white adipocyte differentiation

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003074 Peroxisome proliferator-activated receptor
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
IPR003077 Peroxisome proliferator-activated receptor, gamma
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator-activated receptor gamma
Protein Entry
PPARG_RAT
UniProt ID
O88275
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=2; IsoId=O88275-1; Sequence=Displayed; Name=1; IsoId=O88275-2; Sequence=VSP_003649;
Enzyme Regulation PDPK1 activates its transcriptional activity independently of its kinase activity
Function Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses (By similarity)
Ptm O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes
Ptm Phosphorylated at basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at induces adipogenic activity (By similarity)
Ptm Phosphorylated by MAPK. The phosphorylation inhibits PPAR gamma activity. {ECO:0000269|PubMed:8943212, ECO:0000269|PubMed:8953045, ECO:0000269|PubMed:9030579}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Cytoplasm . Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation (By similarity)
Subunit Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with CCRN4L/NOC. Interacts with FOXO1 (acetylated form) (By similarity)
Tissue Specificity Highest expression in adipose tissue.

Identical and Related Proteins

Unique RefSeq proteins for LMP012541 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981386 RefSeq NP_037256 505 peroxisome proliferator-activated receptor gamma isoform 1
223941854 RefSeq NP_001138838 475 peroxisome proliferator-activated receptor gamma isoform 2

Identical Sequences to LMP012541 proteins

Reference Database Accession Length Protein Name
GI:6981386 DBBJ BAA36485.1 505 PPAR gamma2 [Rattus norvegicus]
GI:6981386 GenBank AAD40119.1 505 peroxisome proliferator-activated receptor gamma 2 [Rattus norvegicus]
GI:6981386 GenBank EDM02154.1 505 peroxisome proliferator activated receptor gamma, isoform CRA_a [Rattus norvegicus]
GI:223941857 GenBank EDM02155.1 475 peroxisome proliferator activated receptor gamma, isoform CRA_b [Rattus norvegicus]
GI:223941854 GenBank EDM02155.1 475 peroxisome proliferator activated receptor gamma, isoform CRA_b [Rattus norvegicus]
GI:223941854 GenBank EDM02156.1 475 peroxisome proliferator activated receptor gamma, isoform CRA_b [Rattus norvegicus]
GI:223941857 GenBank EDM02156.1 475 peroxisome proliferator activated receptor gamma, isoform CRA_b [Rattus norvegicus]
GI:223941857 RefSeq NP_001138838.1 475 peroxisome proliferator-activated receptor gamma isoform 2 [Rattus norvegicus]
GI:223941854 RefSeq NP_001138839.1 475 peroxisome proliferator-activated receptor gamma isoform 2 [Rattus norvegicus]
GI:223941857 RefSeq XP_006237071.1 475 PREDICTED: peroxisome proliferator-activated receptor gamma isoform X1 [Rattus norvegicus]
GI:223941854 RefSeq XP_006237071.1 475 PREDICTED: peroxisome proliferator-activated receptor gamma isoform X1 [Rattus norvegicus]
GI:6981386 SwissProt O88275.2 505 RecName: Full=Peroxisome proliferator-activated receptor gamma; Short=PPAR-gamma; AltName: Full=Nuclear receptor subfamily 1 group C member 3 [Rattus norvegicus]

Related Sequences to LMP012541 proteins

Reference Database Accession Length Protein Name
GI:223941857 GenBank AAD40118.1 475 peroxisome proliferator-activated receptor gamma 1 [Rattus norvegicus]
GI:223941854 GenBank AAD40118.1 475 peroxisome proliferator-activated receptor gamma 1 [Rattus norvegicus]
GI:6981386 GenBank AAD40119.1 505 peroxisome proliferator-activated receptor gamma 2 [Rattus norvegicus]
GI:223941857 GenBank AAF63385.1 475 peroxisome proliferator-activated receptor [Rattus norvegicus]
GI:223941854 GenBank AAF63385.1 475 peroxisome proliferator-activated receptor [Rattus norvegicus]
GI:223941854 GenBank AAF63386.1 475 peroxisome proliferator-activated receptor [Rattus norvegicus]
GI:223941857 GenBank AAF63386.1 475 peroxisome proliferator-activated receptor [Rattus norvegicus]
GI:6981386 GenBank EDM02154.1 505 peroxisome proliferator activated receptor gamma, isoform CRA_a [Rattus norvegicus]
GI:6981386 SwissProt O88275.2 505 RecName: Full=Peroxisome proliferator-activated receptor gamma; Short=PPAR-gamma; AltName: Full=Nuclear receptor subfamily 1 group C member 3 [Rattus norvegicus]