Gene/Proteome Database (LMPD)

LMPD ID
LMP012547
Gene ID
25682
Species
Rattus norvegicus (Rat)
Gene Name
peroxisome proliferator-activated receptor delta
Gene Symbol
Ppard
Synonyms
Pparb;
Alternate Names
peroxisome proliferator-activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor, delta;
Chromosome
20
Map Location
20p12
Summary
transcription factor of the nuclear hormone receptor superfamily; may mediate the intestinal expression of target genes implicated in lipid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ppard

Proteins

peroxisome proliferator-activated receptor delta
Refseq ID NP_037273
Protein GI 241666434
UniProt ID Q99ND3
mRNA ID NM_013141
Length 440
MEQPQEETPEAREEEKEEVATGDGAPELNGGPEHTLPSSSCTDLSQNSSPSSLLDQLQMGCDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLKYEKCDRICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQQNPQLADLKAFSKHIYNAYLKNFNMTKKKARSILTGKSSHNAPFIIHDIETLWQAEKGLVWKQLVNGPPPYNEISVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSIRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILQALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHPLLQEIYKDMY

Gene Information

Entrez Gene ID
25682
Gene Name
peroxisome proliferator-activated receptor delta
Gene Symbol
Ppard
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:RGD C nucleus
GO:0008144 IEA:Ensembl F drug binding
GO:0005504 IDA:RGD F fatty acid binding
GO:0004879 TAS:RGD F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0070539 IEA:Ensembl F linoleic acid binding
GO:0051059 IPI:RGD F NF-kappaB binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 TAS:RGD F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0003713 IDA:RGD F transcription coactivator activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0060612 IEA:Ensembl P adipose tissue development
GO:0097190 IEA:Ensembl P apoptotic signaling pathway
GO:0008366 IEA:Ensembl P axon ensheathment
GO:0030154 IEA:Ensembl P cell differentiation
GO:0031589 IEA:Ensembl P cell-substrate adhesion
GO:0071456 IEA:Ensembl P cellular response to hypoxia
GO:0046697 IEP:RGD P decidualization
GO:0007566 IEP:RGD P embryo implantation
GO:0006635 IEA:Ensembl P fatty acid beta-oxidation
GO:0019395 IDA:RGD P fatty acid oxidation
GO:0015908 IEA:Ensembl P fatty acid transport
GO:0007507 IEP:RGD P heart development
GO:0030522 TAS:GOC P intracellular receptor signaling pathway
GO:0051546 IEA:Ensembl P keratinocyte migration
GO:0043616 IEA:Ensembl P keratinocyte proliferation
GO:0006629 IDA:RGD P lipid metabolic process
GO:0009299 IDA:RGD P mRNA transcription
GO:0043066 IDA:RGD P negative regulation of apoptotic process
GO:0030308 IDA:RGD P negative regulation of cell growth
GO:0032966 IMP:RGD P negative regulation of collagen biosynthetic process
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0050728 IDA:RGD P negative regulation of inflammatory response
GO:0014912 IDA:RGD P negative regulation of smooth muscle cell migration
GO:0048662 IDA:RGD P negative regulation of smooth muscle cell proliferation
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0008654 IDA:RGD P phospholipid biosynthetic process
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0045684 IDA:RGD P positive regulation of epidermis development
GO:0032024 IDA:RGD P positive regulation of insulin secretion
GO:0014068 IEA:Ensembl P positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045893 IEA:Ensembl P positive regulation of transcription, DNA-templated
GO:0045909 IDA:RGD P positive regulation of vasodilation
GO:0006029 IDA:RGD P proteoglycan metabolic process
GO:0045598 IEA:Ensembl P regulation of fat cell differentiation
GO:0014823 IEP:RGD P response to activity
GO:0009749 IEP:RGD P response to glucose
GO:0010033 IEP:RGD P response to organic substance
GO:0033189 IEP:RGD P response to vitamin A
GO:0006776 IMP:RGD P vitamin A metabolic process
GO:0042060 IEA:Ensembl P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
rno05200 Pathways in cancer
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko04310 Wnt signaling pathway
rno04310 Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953330 Gene Expression
5953833 Generic Transcription Pathway
5953467 Import of palmitoyl-CoA into the mitochondrial matrix
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954147 Nuclear Receptor transcription pathway
5953268 Pyruvate metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5954047 Regulation of pyruvate dehydrogenase (PDH) complex
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003074 Peroxisome proliferator-activated receptor
IPR003075 Peroxisome proliferator-activated receptor, beta
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator-activated receptor delta
Protein Entry
Q99ND3_RAT
UniProt ID
Q99ND3
Species
Rat

Comments

Comment Type Description
Similarity Belongs to the nuclear hormone receptor family
Similarity Contains nuclear receptor DNA-binding domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012547 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
241666434 RefSeq NP_037273 440 peroxisome proliferator-activated receptor delta

Identical Sequences to LMP012547 proteins

Reference Database Accession Length Protein Name
GI:241666434 RefSeq XP_006256228.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Rattus norvegicus]
GI:241666434 RefSeq XP_006256229.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Rattus norvegicus]
GI:241666434 RefSeq XP_006256230.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Rattus norvegicus]
GI:241666434 RefSeq XP_008771019.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Rattus norvegicus]

Related Sequences to LMP012547 proteins

Reference Database Accession Length Protein Name
GI:241666434 EMBL CAC29088.1 440 peroxisome proliferator-activated receptor beta [Rattus norvegicus]
GI:241666434 RefSeq XP_006256229.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Rattus norvegicus]
GI:241666434 RefSeq XP_006256230.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Rattus norvegicus]