Gene/Proteome Database (LMPD)

LMPD ID
LMP012576
Gene ID
29322
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol
Plcb3
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; PLC-beta-3; phospholipase C beta 3; phospholipase C-beta-3; phosphoinositide phospholipase C-beta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3;
Chromosome
1
Map Location
1q43
EC Number
3.1.4.11
Summary
phospholipase C isozyme activated by Gq class G proteins [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Plcb3

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Refseq ID NP_203501
Protein GI 71894813
UniProt ID Q45QJ4
mRNA ID NM_033350
Length 1236
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYEPNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLSAGTPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEEGLNRGPNVLMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTEMCQETPSQQQGSQLSSNPAPNPLDASPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSSSALSRATNVEDVKEEEKEAARQYREFQNRQVQSLLELREAQADAETERRLEHLKQAQQRLREVVLDAHTTQFKRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLLAGQQQVLQQLVEEEPKLVAQLTQECQEQRERLPQEIRRCLLGETSEGLGDGPLVACASNGHAAGSGGHQSGADSESQEENTQL

Gene Information

Entrez Gene ID
29322
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol
Plcb3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:Ensembl C nucleus
GO:0043234 IEA:Ensembl C protein complex
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0003073 IEA:Ensembl P regulation of systemic arterial blood pressure
GO:0007268 IEA:InterPro P synaptic transmission

KEGG Pathway Links

KEGG Pathway ID Description
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko05143 African trypanosomiasis
rno05143 African trypanosomiasis
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko04713 Circadian entrainment
rno04713 Circadian entrainment
ko04728 Dopaminergic synapse
rno04728 Dopaminergic synapse
ko04961 Endocrine and other factor-regulated calcium reabsorption
rno04961 Endocrine and other factor-regulated calcium reabsorption
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04540 Gap junction
rno04540 Gap junction
ko04971 Gastric acid secretion
rno04971 Gastric acid secretion
ko04724 Glutamatergic synapse
rno04724 Glutamatergic synapse
ko04912 GnRH signaling pathway
rno04912 GnRH signaling pathway
ko05016 Huntington's disease
rno05016 Huntington's disease
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno04911 Insulin secretion
ko04730 Long-term depression
rno04730 Long-term depression
ko04720 Long-term potentiation
rno04720 Long-term potentiation
ko04916 Melanogenesis
rno04916 Melanogenesis
rno01100 Metabolic pathways
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
ko04723 Retrograde endocannabinoid signaling
rno04723 Retrograde endocannabinoid signaling
ko04970 Salivary secretion
rno04970 Salivary secretion
rno04726 Serotonergic synapse
rno04919 Thyroid hormone signaling pathway
ko04918 Thyroid hormone synthesis
rno04918 Thyroid hormone synthesis
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko04310 Wnt signaling pathway
rno04310 Wnt signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954319 Activation of Kainate Receptors upon glutamate binding
5953801 Ca2+ pathway
5953653 G alpha (q) signalling events
5954210 G beta:gamma signalling through PLC beta
5954003 G-protein beta:gamma signalling
5953389 G-protein mediated events
5953642 GPCR downstream signaling
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954515 Inositol phosphate metabolism
5953250 Metabolism
5953277 Neuronal System
5953606 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
5953390 Opioid Signalling
5953388 PLC beta mediated events
5954324 Presynaptic function of Kainate receptors
5953381 Signal Transduction
5953391 Signaling by GPCR
5953803 Signaling by Wnt
5954514 Synthesis of IP3 and IP4 in the cytosol
5953276 Transmission across Chemical Synapses
5953802 beta-catenin independent WNT signaling

Domain Information

InterPro Annotations

Accession Description
IPR028390 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Protein Entry
Q45QJ4_RAT
UniProt ID
Q45QJ4
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Similarity Contains 1 C2 domain
Similarity Contains 1 PI-PLC X-box domain
Similarity Contains 1 PI-PLC Y-box domain
Similarity Contains C2 domain
Similarity Contains Cdomain
Similarity Contains PI-PLC X-box domain
Similarity Contains PI-PLC Y-box domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012576 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71894813 RefSeq NP_203501 1236 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Identical Sequences to LMP012576 proteins

Reference Database Accession Length Protein Name
GI:71894813 GenBank AAZ23846.1 1236 phospholipase C beta 3 [Rattus norvegicus]
GI:71894813 GenBank AAZ23847.1 1236 phospholipase C beta 3 [Rattus norvegicus]
GI:71894813 GenBank EDM12633.1 1236 phospholipase C, beta 3 [Rattus norvegicus]
GI:71894813 RefSeq XP_006230773.1 1236 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012576 proteins

Reference Database Accession Length Protein Name
GI:71894813 GenBank AAZ23846.1 1236 phospholipase C beta 3 [Rattus norvegicus]
GI:71894813 GenBank AAZ23847.1 1236 phospholipase C beta 3 [Rattus norvegicus]
GI:71894813 RefSeq XP_006230773.1 1236 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [Rattus norvegicus]