Gene/Proteome Database (LMPD)

LMPD ID
LMP012605
Gene ID
29539
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 2 family (mitochondrial)
Gene Symbol
Aldh2
Alternate Names
aldehyde dehydrogenase, mitochondrial; ALDH1; ALDH-E2; ALDH class 2; mitochondrial aldehyde dehydrogenase; aldehyde dehydrogenase 2, mitochondrial;
Chromosome
12
Map Location
12q16
EC Number
1.2.1.3

Proteins

aldehyde dehydrogenase, mitochondrial precursor
Refseq ID NP_115792
Protein GI 14192933
UniProt ID P11884
mRNA ID NM_032416
Length 519
MLRAALSTARRGPRLSRLLSAAATSAVPAPNQQPEVFCNQIFINNEWHDAVSKKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAAQAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
transit_peptide: 1..19 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P11884.1) calculated_mol_wt: 2139 peptide sequence: MLRAALSTARRGPRLSRLL mat_peptide: 20..519 product: aldehyde dehydrogenase, mitochondrial calculated_mol_wt: 54368 peptide sequence: SAAATSAVPAPNQQPEVFCNQIFINNEWHDAVSKKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAAQAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

Gene Information

Entrez Gene ID
29539
Gene Name
aldehyde dehydrogenase 2 family (mitochondrial)
Gene Symbol
Aldh2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0070404 IDA:RGD F NADH binding
GO:0004029 IDA:RGD F aldehyde dehydrogenase (NAD) activity
GO:0042802 IDA:RGD F identical protein binding
GO:0071398 IEP:RGD P cellular response to fatty acid
GO:0032870 IEP:RGD P cellular response to hormone stimulus
GO:0006068 IEA:UniProtKB-UniPathway P ethanol catabolic process
GO:0001889 IEP:RGD P liver development
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0032355 IEP:RGD P response to estradiol
GO:0055093 IEP:RGD P response to hyperoxia
GO:0032496 IEP:RGD P response to lipopolysaccharide
GO:0035094 IEP:RGD P response to nicotine
GO:0032570 IEP:RGD P response to progesterone
GO:0033574 IEP:RGD P response to testosterone

KEGG Pathway Links

KEGG Pathway ID Description
ko00330 Arginine and proline metabolism
rno00330 Arginine and proline metabolism
ko00053 Ascorbate and aldarate metabolism
rno00053 Ascorbate and aldarate metabolism
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
M00135 GABA biosynthesis, eukaryotes, putrescine => GABA
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
ko00340 Histidine metabolism
rno00340 Histidine metabolism
ko00310 Lysine degradation
rno00310 Lysine degradation
rno01100 Metabolic pathways
ko00040 Pentose and glucuronate interconversions
rno00040 Pentose and glucuronate interconversions
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation
ko00410 beta-Alanine metabolism
rno00410 beta-Alanine metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953258 Biological oxidations
5953325 Ethanol oxidation
5953250 Metabolism
5953672 Metabolism of serotonin
5953277 Neuronal System
5953674 Neurotransmitter Clearance In The Synaptic Cleft
5953326 Phase 1 - Functionalization of compounds
5953673 Serotonin clearance from the synaptic cleft
5953276 Transmission across Chemical Synapses

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 2 family (mitochondrial)
Protein Entry
ALDH2_RAT
UniProt ID
P11884
Species
Rat

Comments

Comment Type Description
Catalytic Activity An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Interaction Q02776:TIM50 (xeno); NbExp=3; IntAct=EBI-916402, EBI-30302;
Pathway Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Similarity Belongs to the aldehyde dehydrogenase family
Subcellular Location Mitochondrion matrix.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012605 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14192933 RefSeq NP_115792 519 aldehyde dehydrogenase, mitochondrial precursor

Identical Sequences to LMP012605 proteins

Reference Database Accession Length Protein Name
GI:14192933 EMBL CAA33101.1 519 aldehyde dehydrogenase preprotein [Rattus norvegicus]
GI:14192933 GenBank AAH62081.1 519 Aldehyde dehydrogenase 2 family (mitochondrial) [Rattus norvegicus]
GI:14192933 SwissProt P11884.1 519 RecName: Full=Aldehyde dehydrogenase, mitochondrial; AltName: Full=ALDH class 2; AltName: Full=ALDH-E2; AltName: Full=ALDH1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012605 proteins

Reference Database Accession Length Protein Name
GI:14192933 EMBL CAA33101.1 519 aldehyde dehydrogenase preprotein [Rattus norvegicus]
GI:14192933 GenBank AAH62081.1 519 Aldehyde dehydrogenase 2 family (mitochondrial) [Rattus norvegicus]
GI:14192933 SwissProt P11884.1 519 RecName: Full=Aldehyde dehydrogenase, mitochondrial; AltName: Full=ALDH class 2; AltName: Full=ALDH-E2; AltName: Full=ALDH1; Flags: Precursor [Rattus norvegicus]