Gene/Proteome Database (LMPD)

LMPD ID
LMP012638
Gene ID
50557
Species
Rattus norvegicus (Rat)
Gene Name
phosphatase and tensin homolog
Gene Symbol
Pten
Synonyms
Mmac; TEP1; MMAC1;
Alternate Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mutated in multiple advanced cancers 1; protein tyrosine phosphatase and tensin-like protein; phosphatase and tensin homolog deleted on chromosome ten; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
Chromosome
1
Map Location
1q41-q43
Summary
may be involved in regulation of phosphoinositide 3-kinase and Akt kinase mediated antiapoptotic pathways [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pten

Proteins

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Refseq ID NP_113794
Protein GI 13928830
UniProt ID O54857
mRNA ID NM_031606
Length 403
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV

Gene Information

Entrez Gene ID
50557
Gene Name
phosphatase and tensin homolog
Gene Symbol
Pten
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0005737 IDA:RGD C cytoplasm
GO:0009898 IEA:Ensembl C cytoplasmic side of plasma membrane
GO:0043197 IDA:RGD C dendritic spine
GO:0005739 IDA:RGD C mitochondrion
GO:0035749 IEA:Ensembl C myelin sheath adaxonal region
GO:0043005 IDA:RGD C neuron projection
GO:0005634 IDA:RGD C nucleus
GO:0045211 IDA:RGD C postsynaptic membrane
GO:0030165 IPI:RGD F PDZ domain binding
GO:0051717 IEA:Ensembl F inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0016314 IDA:RGD F phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 IEA:InterPro F phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438 IEA:Ensembl F phosphatidylinositol-3-phosphatase activity
GO:0005161 IDA:RGD F platelet-derived growth factor receptor binding
GO:0004722 IEA:Ensembl F protein serine/threonine phosphatase activity
GO:0004725 IEA:InterPro F protein tyrosine phosphatase activity
GO:0008138 TAS:RGD F protein tyrosine/serine/threonine phosphatase activity
GO:0007092 IEA:Ensembl P activation of mitotic anaphase-promoting complex activity
GO:0007568 IEP:RGD P aging
GO:0001525 IEA:Ensembl P angiogenesis
GO:0060070 IEA:Ensembl P canonical Wnt signaling pathway
GO:0048738 IEA:Ensembl P cardiac muscle tissue development
GO:0032286 IEA:Ensembl P central nervous system myelin maintenance
GO:0021955 IEA:Ensembl P central nervous system neuron axonogenesis
GO:0060997 IEA:Ensembl P dendritic spine morphogenesis
GO:0021542 IEA:Ensembl P dentate gyrus development
GO:0043542 IEA:Ensembl P endothelial cell migration
GO:0048853 IEA:Ensembl P forebrain morphogenesis
GO:0046855 IEA:InterPro P inositol phosphate dephosphorylation
GO:0045475 IEA:Ensembl P locomotor rhythm
GO:0060292 IMP:RGD P long term synaptic depression
GO:0060291 IEA:Ensembl P long-term synaptic potentiation
GO:0060179 IEA:Ensembl P male mating behavior
GO:0042711 IEA:Ensembl P maternal behavior
GO:0007613 IMP:RGD P memory
GO:0033555 IEA:Ensembl P multicellular organismal response to stress
GO:2000134 IEA:Ensembl P negative regulation of G1/S transition of mitotic cell cycle
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0050771 IEA:Ensembl P negative regulation of axonogenesis
GO:0090344 IEA:Ensembl P negative regulation of cell aging
GO:0030336 IEA:InterPro P negative regulation of cell migration
GO:0008285 IDA:RGD P negative regulation of cell proliferation
GO:0045792 IEA:Ensembl P negative regulation of cell size
GO:0031658 IEA:Ensembl P negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002 IEA:Ensembl P negative regulation of dendritic spine morphogenesis
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0090394 IEA:Ensembl P negative regulation of excitatory postsynaptic membrane potential
GO:0051895 IEA:InterPro P negative regulation of focal adhesion assembly
GO:0031642 IEA:Ensembl P negative regulation of myelination
GO:0046621 IEA:Ensembl P negative regulation of organ growth
GO:0050765 IMP:RGD P negative regulation of phagocytosis
GO:0051898 IEA:Ensembl P negative regulation of protein kinase B signaling
GO:0090071 IEA:Ensembl P negative regulation of ribosome biogenesis
GO:2000808 IEA:Ensembl P negative regulation of synaptic vesicle clustering
GO:0031175 IDA:RGD P neuron projection development
GO:0007270 IEA:Ensembl P neuron-neuron synaptic transmission
GO:0046856 IMP:RGD P phosphatidylinositol dephosphorylation
GO:0048008 IDA:RGD P platelet-derived growth factor receptor signaling pathway
GO:0043065 IMP:RGD P positive regulation of apoptotic process
GO:2001235 IEA:Ensembl P positive regulation of apoptotic signaling pathway
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:2000463 IEA:Ensembl P positive regulation of excitatory postsynaptic membrane potential
GO:2000060 IEA:Ensembl P positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091 IEA:Ensembl P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107 IEA:Ensembl P postsynaptic density assembly
GO:0060134 IEA:Ensembl P prepulse inhibition
GO:0097105 IEA:Ensembl P presynaptic membrane assembly
GO:0060736 IEA:Ensembl P prostate gland growth
GO:0043491 IEA:Ensembl P protein kinase B signaling
GO:0050821 IEA:Ensembl P protein stabilization
GO:0002902 IEA:Ensembl P regulation of B cell apoptotic process
GO:0033032 IEA:Ensembl P regulation of myeloid cell apoptotic process
GO:0033198 IEP:RGD P response to ATP
GO:0046685 IEP:RGD P response to arsenic-containing substance
GO:0042493 IEP:RGD P response to drug
GO:0032355 IEP:RGD P response to estradiol
GO:0045471 IEP:RGD P response to ethanol
GO:0009749 IEP:RGD P response to glucose
GO:0010035 IEP:RGD P response to inorganic substance
GO:0007584 IEP:RGD P response to nutrient
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010033 IEP:RGD P response to organic substance
GO:0010043 IEP:RGD P response to zinc ion
GO:0060024 IEA:Ensembl P rhythmic synaptic transmission
GO:0035176 IEA:Ensembl P social behavior
GO:0060074 IEA:Ensembl P synapse maturation

KEGG Pathway Links

KEGG Pathway ID Description
ko05213 Endometrial cancer
rno05213 Endometrial cancer
ko04510 Focal adhesion
rno04510 Focal adhesion
rno04068 FoxO signaling pathway
ko05214 Glioma
rno05214 Glioma
rno05161 Hepatitis B
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
ko05218 Melanoma
rno05218 Melanoma
ko05206 MicroRNAs in cancer
rno05206 MicroRNAs in cancer
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko05215 Prostate cancer
rno05215 Prostate cancer
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko04530 Tight junction
rno04530 Tight junction
ko04150 mTOR signaling pathway
rno04150 mTOR signaling pathway
ko04115 p53 signaling pathway
rno04115 p53 signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5954570 Constitutive PI3K/AKT Signaling in Cancer
5953408 DAP12 interactions
5953407 DAP12 signaling
5953253 Disease
5954035 Downstream TCR signaling
5953396 Downstream signal transduction
5953994 Downstream signaling events of B Cell Receptor (BCR)
5953399 Downstream signaling of activated FGFR
5953417 Fc epsilon receptor (FCERI) signaling
5953884 GAB1 signalosome
5953410 Immune System
5953409 Innate Immune System
5954515 Inositol phosphate metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953394 NGF signalling via TRKA from the plasma membrane
5954013 Negative regulation of the PI3K/AKT network
5954478 PI Metabolism
5953885 PI-3K cascade
5953996 PI3K events in ERBB2 signaling
5953995 PI3K events in ERBB4 signaling
5953997 PI3K/AKT Signaling in Cancer
5953989 PI3K/AKT activation
5953993 PIP3 activates AKT signaling
5953474 Phospholipid metabolism
5953998 Role of LAT2/NTAL/LAB on calcium mobilization
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953540 Signaling by ERBB4
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5953397 Signaling by PDGF
5953541 Signaling by SCF-KIT
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF
5954514 Synthesis of IP3 and IP4 in the cytosol
5954499 Synthesis of PIPs at the plasma membrane
5954036 TCR signaling

Domain Information

InterPro Annotations

Accession Description
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR000008 C2 domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR016130 Protein-tyrosine phosphatase, active site
IPR029021 Protein-tyrosine phosphatase-like
IPR014020 Tensin phosphatase, C2 domain
IPR029023 Tensin phosphatase, lipid phosphatase domain

UniProt Annotations

Entry Information

Gene Name
phosphatase and tensin homolog
Protein Entry
O54857_RAT
UniProt ID
O54857
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012638 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13928830 RefSeq NP_113794 403 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Identical Sequences to LMP012638 proteins

Reference Database Accession Length Protein Name
GI:13928830 GenBank AAB96620.1 403 protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers protein [Rattus norvegicus]
GI:13928830 GenBank AAO31948.1 403 protein tyrosine phosphatase and tensin-like protein [Rattus norvegicus]
GI:13928830 GenBank EDM13141.1 403 phosphatase and tensin homolog, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012638 proteins

Reference Database Accession Length Protein Name
GI:13928830 GenBank AAB96620.1 403 protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers protein [Rattus norvegicus]
GI:13928830 GenBank AAO31948.1 403 protein tyrosine phosphatase and tensin-like protein [Rattus norvegicus]
GI:13928830 GenBank EDM13141.1 403 phosphatase and tensin homolog, isoform CRA_a [Rattus norvegicus]