Gene/Proteome Database (LMPD)
LMPD ID
LMP012642
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
fatty acid synthase
Gene Symbol
Alternate Names
fatty acid synthase;
Chromosome
10
Map Location
chromosome:10
EC Number
2.3.1.85
Summary
plays a role in lipid biosynthesis [RGD, Feb 2006]
Orthologs
Proteins
| fatty acid synthase | |
|---|---|
| Refseq ID | NP_059028 |
| Protein GI | 8394158 |
| UniProt ID | P12785 |
| mRNA ID | NM_017332 |
| Length | 2505 |
| MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGLYGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRGTNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTACSSSLLALQNAYQAIRSGECPAAIVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDSGNGYCRAEAVVAVLLTKKSLARRVYATILNAGTNTDGCKEQGVTFPSGEAQEQLIRSLYQPGGVAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQSPLLIGSTKSNMGHPEPASGLAALTKVLLSLENGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGIVGINSFGFGGANVHVILQPNTQQAPAPAPHAALPHLLHASGRTMEAVQGLLEQGRQHSQDLAFVSMLNDIAATPTAAMPFRGYTVLGVEGHVQEVQQVPASQRPLWFICSGMGTQWRGMGLSLMRLDSFRESILRSDEALKPLGVKVSDLLLSTDEHTFDDIVHSFVSLTAIQIALIDLLTSMGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDANLPAGSMAAVGLSWEECKQRCPPGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAFHSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGVKPSCTIIPLMKRDHKDNLEFFLTNLGKVHLTGIDINPNALFPPVEFPVPRGTPLISPHIKWDHSQTWDIPVAEDFPNGSSSSSATVYNIDASSESSDHYLVDHCIDGRVLFPGTGYLYLVWKTLARSLSLSLEETPVVFENVTFHQATILPRTGTVPLEVRLLEASHAFEVSDSGNLIVSGKVYQWEDPDSKLFDHPEVPIPAESESVSRLTQGEVYKELRLRGYDYGPHFQGVYEATLEGEQGKLLWKDNWVTFMDTMLQISILGFSKQSLQLPTRVTAIYIDPATHLQKVYMLEGDTQVADVTTSRCLGVTVSGGVYISRLQTTATSRRQQEQLVPTLEKFVFTPHVEPECLSESAILQKELQLCKGLAKALQTKATQQGLKMTVPGLEDLPQHGLPRLLAAACQLQLNGNLQLELGEVLARERLLLPEDPLISGLLNSQALKACIDTALENLSTLKMKVVEVLAGEGHLYSHISALLNTQPMLQLEYTATDRHPQALKDVQTKLQQHDVAQGQWDPSGPAPTNLGALDLVVCNCALATLGDPALALDNMVAALKDGGFLLMHTVLKGHALGETLACLPSEVQPGPSFLSQEEWESLFSRKALHLVGLKKSFYGTALFLCRRLSPQDKPIFLPVEDTSFQWVDSLKSILATSSSQPVWLTAMNCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSSTSHVPKLDPGSSELQKVLESDLVMNVYRDGAWGAFRHFQLEQDKPEEQTAHAFVNVLTRGDLASIRWVSSPLKHMQPPSSSGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDKCGRRVMGLVPAEGLATSVLLSPDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQHGETVLIHSGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHVLLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTFHGILLDALFEGANDSWREVAELLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHIGKVLVQVREEEPEAMLPGAQPTLISAISKTFCPEHKSYIITGGLGGFGLELARWLVLRGAQRLVLTSRSGIRTGYQAKHVREWRRQGIHVLVSTSNVSSLEGARALIAEATKLGPVGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSVSCGRGNAGQSNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIILEAMGTNDTVVGGTLPQRISSCMEVLDLFLNQPHAVLSSFVLVEKKAVAHGDGEAQRDLVKAVAHILGIRDLAGINLDSSLADLGLDSLMGVEVRQILEREHDLVLPIREVRQLTLRKLQEMSSKAGSDTELAAPKSKNDTSLKQAQLNLSILLVNPEGPTLTRLNSVQSSERPLFLVHPIEGSITVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPHRVAGYSFGACVAFEMCSQLQAQQGPAPAHNNLFLFDGSHTYVLAYTQSYRAKLTPGCEAEAEAEAICFFIKQFVDAEHSKVLEALLPLKSLEDRVAAAVDLITRSHQSLDRRDLSFAAVSFYYKLRAADQYKPKAKYHGNVILLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLEGRGLESIINIIHSSLAEPRVSVREG | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IEA:Ensembl | C | Golgi apparatus |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0042587 | IEA:Ensembl | C | glycogen granule |
| GO:0005739 | IEA:Ensembl | C | mitochondrion |
| GO:0005886 | IEA:Ensembl | C | plasma membrane |
| GO:0047451 | IEA:UniProtKB-EC | F | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity |
| GO:0004317 | IEA:InterPro | F | 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity |
| GO:0004316 | IEA:UniProtKB-EC | F | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| GO:0004315 | IEA:UniProtKB-EC | F | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| GO:0070402 | IDA:RGD | F | NADPH binding |
| GO:0004313 | IEA:UniProtKB-EC | F | [acyl-carrier-protein] S-acetyltransferase activity |
| GO:0004314 | IEA:UniProtKB-EC | F | [acyl-carrier-protein] S-malonyltransferase activity |
| GO:0008144 | IDA:RGD | F | drug binding |
| GO:0047117 | IEA:UniProtKB-EC | F | enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity |
| GO:0004319 | IEA:InterPro | F | enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity |
| GO:0004312 | IDA:RGD | F | fatty acid synthase activity |
| GO:0042802 | IPI:IntAct | F | identical protein binding |
| GO:0016295 | IEA:UniProtKB-EC | F | myristoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0004320 | IEA:UniProtKB-EC | F | oleoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0016296 | IEA:UniProtKB-EC | F | palmitoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0044822 | IEA:Ensembl | F | poly(A) RNA binding |
| GO:0042803 | IDA:RGD | F | protein homodimerization activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0006084 | IDA:RGD | P | acetyl-CoA metabolic process |
| GO:0071353 | IEA:Ensembl | P | cellular response to interleukin-4 |
| GO:0006633 | IMP:RGD | P | fatty acid biosynthetic process |
| GO:0008610 | TAS:RGD | P | lipid biosynthetic process |
| GO:0001649 | IEA:Ensembl | P | osteoblast differentiation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04152 | AMPK signaling pathway |
| rno04152 | AMPK signaling pathway |
| ko00061 | Fatty acid biosynthesis |
| rno00061 | Fatty acid biosynthesis |
| M00083 | Fatty acid biosynthesis, elongation |
| M00082 | Fatty acid biosynthesis, initiation |
| ko01212 | Fatty acid metabolism |
| rno01212 | Fatty acid metabolism |
| ko04910 | Insulin signaling pathway |
| rno04910 | Insulin signaling pathway |
| rno01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954496 | Activation of gene expression by SREBF (SREBP) |
| 5953760 | ChREBP activates metabolic gene expression |
| 5953298 | Defective AMN causes hereditary megaloblastic anemia 1 |
| 5953308 | Defective BTD causes biotidinase deficiency |
| 5953307 | Defective CD320 causes methylmalonic aciduria |
| 5953299 | Defective CUBN causes hereditary megaloblastic anemia 1 |
| 5953296 | Defective GIF causes intrinsic factor deficiency |
| 5953310 | Defective HLCS causes multiple carboxylase deficiency |
| 5953297 | Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF |
| 5953305 | Defective MMAA causes methylmalonic aciduria type cblA |
| 5953302 | Defective MMAB causes methylmalonic aciduria type cblB |
| 5953304 | Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC |
| 5953303 | Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD |
| 5953301 | Defective MTR causes methylmalonic aciduria and homocystinuria type cblG |
| 5953300 | Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE |
| 5953306 | Defective MUT causes methylmalonic aciduria mut type |
| 5953293 | Defective TCN2 causes hereditary megaloblastic anemia |
| 5953309 | Defects in biotin (Btn) metabolism |
| 5953294 | Defects in cobalamin (B12) metabolism |
| 5953295 | Defects in vitamin and cofactor metabolism |
| 5953253 | Disease |
| 5953463 | Fatty Acyl-CoA Biosynthesis |
| 5953288 | Fatty acid, triacylglycerol, and ketone body metabolism |
| 5953611 | Integration of energy metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953292 | Metabolism of vitamins and cofactors |
| 5953291 | Metabolism of water-soluble vitamins and cofactors |
| 5954497 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| 5953464 | Triglyceride Biosynthesis |
| 5953985 | Vitamin B5 (pantothenate) metabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR009081 | Acyl carrier protein-like |
| IPR014043 | Acyl transferase |
| IPR001227 | Acyl transferase domain |
| IPR016035 | Acyl transferase/acyl hydrolase/lysophospholipase |
| IPR013149 | Alcohol dehydrogenase, C-terminal |
| IPR029058 | Alpha/Beta hydrolase fold |
| IPR014031 | Beta-ketoacyl synthase, C-terminal |
| IPR014030 | Beta-ketoacyl synthase, N-terminal |
| IPR018201 | Beta-ketoacyl synthase, active site |
| IPR023102 | Fatty acid synthase, domain 2 |
| IPR011032 | GroES (chaperonin 10)-like |
| IPR016036 | Malonyl-CoA ACP transacylase, ACP-binding |
| IPR013217 | Methyltransferase type 12 |
| IPR016040 | NAD(P)-binding domain |
| IPR006162 | Phosphopantetheine attachment site |
| IPR020843 | Polyketide synthase, enoylreductase domain |
| IPR013968 | Polyketide synthase, ketoreductase domain |
| IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| IPR001031 | Thioesterase |
| IPR016039 | Thiolase-like |
| IPR016038 | Thiolase-like, subgroup |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. |
| Catalytic Activity | A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. |
| Catalytic Activity | Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]. |
| Catalytic Activity | Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+). |
| Catalytic Activity | Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. |
| Catalytic Activity | An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH. |
| Catalytic Activity | Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]. |
| Catalytic Activity | Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate. |
| Function | Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. |
| Induction | Up-regulated in livers of rats fed on a high carbohydrate diet |
| Interaction | Self; NbExp=8; IntAct=EBI-493558, EBI-493558; |
| Similarity | Contains 1 acyl carrier domain. {ECO:0000255|PROSITE- ProRule:PRU00258}. |
| Subcellular Location | Cytoplasm . Melanosome . |
| Subunit | Homodimer which is arranged in a head to tail fashion. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012642 (as displayed in Record Overview)
Identical Sequences to LMP012642 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:8394158 | GenBank | AAA57219.1 | 2505 | fatty acid synthase [Rattus norvegicus] |
| GI:8394158 | GenBank | AEK13591.1 | 2505 | Sequence 3 from patent US 7972785 |
Related Sequences to LMP012642 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:8394158 | EMBL | CAA44680.1 | 2505 | fatty acid synthase [Rattus norvegicus] |
| GI:8394158 | GenBank | AAA57219.1 | 2505 | fatty acid synthase [Rattus norvegicus] |
| GI:8394158 | GenBank | AEK13591.1 | 2505 | Sequence 3 from patent US 7972785 |