Gene/Proteome Database (LMPD)

LMPD ID
LMP012658
Gene ID
57300
Species
Rattus norvegicus (Rat)
Gene Name
arylacetamide deacetylase
Gene Symbol
Aadac
Synonyms
Aada;
Alternate Names
arylacetamide deacetylase; arylacetamide deacetylase (esterase);
Chromosome
2
Map Location
2q31
EC Number
3.1.1.3;

Proteins

arylacetamide deacetylase
Refseq ID NP_065413
Protein GI 10120490
UniProt ID Q9QZH8
mRNA ID NM_020538
Length 398
MGRTIFLLISVVLVAYYIYIPLPDDIEEPWKIILGNTLLKLGGDLASFGELLGLNHFMDTVQLFMRFQVVPPTSDENVTVMETDFNSVPVRIYIPKRKSTTLRRGLFFIHGGGWCLGSAAYFMYDTLSRRTAHRLDAVVVSTDYGLAPKYHFPKQFEDVYHSLRWFLQEDILEKYGVDPRRVGVSGDSAGGNLTAAVTQQILQDPDVKIKLKVQALIYPALQALDMNVPSQQENSQYPLLTRSLLIRFWSEYFTTDRDLEKAMLLNQHVPVEFSHLLQFVNWSSLLPQRYKKGYFYKTPTPGSLELAQKYPGFTDVKACPLLANDSILHHLPMTYIITCQYDVLRDDGLMYVKRLQNTGVHVTHHHIEDGFHGALTLPGLKITYRMQNQYLNWLHKNL

Gene Information

Entrez Gene ID
57300
Gene Name
arylacetamide deacetylase
Gene Symbol
Aadac
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:UniProtKB C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0019213 ISS:UniProtKB F deacetylase activity
GO:0004806 IEA:UniProtKB-EC F triglyceride lipase activity
GO:0006629 NAS:RGD P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013094 Alpha/beta hydrolase fold-3
IPR017157 Arylacetamide deacetylase
IPR002168 Lipase, GDXG, active site

UniProt Annotations

Entry Information

Gene Name
arylacetamide deacetylase
Protein Entry
AAAD_RAT
UniProt ID
Q9QZH8
Species
Rat

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000250, ECO:0000269|PubMed:22207054}.
Similarity Belongs to the 'GDXG' lipolytic enzyme family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein . Microsome membrane ; Single-pass type II membrane protein .
Tissue Specificity Highest levels in liver with lower levels in jejunum, kidney and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012658 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10120490 RefSeq NP_065413 398 arylacetamide deacetylase

Identical Sequences to LMP012658 proteins

Reference Database Accession Length Protein Name
GI:10120490 GenBank AAD56394.1 398 arylacetamide deacetylase [Rattus norvegicus]
GI:10120490 GenBank AAF74757.1 398 arylacetamide deacetylase [Rattus norvegicus]
GI:10120490 SwissProt Q9QZH8.3 398 RecName: Full=Arylacetamide deacetylase [Rattus norvegicus]

Related Sequences to LMP012658 proteins

Reference Database Accession Length Protein Name
GI:10120490 GenBank AAD56394.1 398 arylacetamide deacetylase [Rattus norvegicus]
GI:10120490 GenBank AAF74757.1 398 arylacetamide deacetylase [Rattus norvegicus]
GI:10120490 SwissProt Q9QZH8.3 398 RecName: Full=Arylacetamide deacetylase [Rattus norvegicus]