Gene/Proteome Database (LMPD)

LMPD ID
LMP012675
Gene ID
60399
Species
Rattus norvegicus (Rat)
Gene Name
sphingosine-1-phosphate receptor 5
Gene Symbol
S1pr5
Synonyms
Edg8; Edg-8;
Alternate Names
sphingosine 1-phosphate receptor 5; S1P5; NRG-1; S1P receptor 5; S1P receptor Edg-8; sphingosine 1-phosphate receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; nerve growth factor-regulated G-protein-coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8;
Chromosome
8
Map Location
8q13
Summary
G protein-coupled receptor for the lysolipid phosphoric acid mediator sphingosine 1-phosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for S1pr5

Proteins

sphingosine 1-phosphate receptor 5
Refseq ID NP_068543
Protein GI 31377521
UniProt ID Q9JKM5
mRNA ID NM_021775
Length 400
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLRLSPALWFAREGGVFVALAASVLSLLAIAIERHLTMARRGPAPAASRARTLAMAVAAWGLLLTLGLLPALGWNCLGRLEACSTVLPVYAKAYVLFCVLAFLGILAAICALYARIYCQVRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSSNSLQRSPSAVGPSGGGLRRCLPPTLDRSSSPSEHSCPQRDGMDTSCSTGSPGAATANRTLVPDATD

Gene Information

Entrez Gene ID
60399
Gene Name
sphingosine-1-phosphate receptor 5
Gene Symbol
S1pr5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:RGD C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 IDA:RGD F G-protein coupled receptor activity
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0045664 IEP:RGD P regulation of neuron differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954152 G alpha (i) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954244 Lysosphingolipid and LPA receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR005386 EDG-8 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 5
Protein Entry
S1PR5_RAT
UniProt ID
Q9JKM5
Species
Rat

Comments

Comment Type Description
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins. Displays antiproliferative effects in transfected CHO-K1 and HEK293 cells.
Induction In PC-12 cells, nerve growth factor induces neuronal differentiation and represses expression of the receptor. Down- regulated also by fibroblast growth factor and dibutyryl cAMP. Epidermal growth factor, an agent that does not induce differentiation, does not repress expression. Protein kinase A appears to be an obligatory cellular component in regulation
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of the brain. Corpus callosum, optic nerve, olfactory tract, anterior commissure, internal and external capsules, fimbra of the hippocampus, mammillary tract, stria medullaris, and white matter of the cerebellum and brain stem all express the receptor. Within the striatum itself white matter fascicles express the receptor. Detected also in spleen and lung. Not observed in heart, liver, skeletal muscle, kidney, or testes. {ECO:0000269|PubMed:10532805, ECO:0000269|PubMed:10799507, ECO:0000269|PubMed:12234605}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012675 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31377521 RefSeq NP_068543 400 sphingosine 1-phosphate receptor 5

Identical Sequences to LMP012675 proteins

Reference Database Accession Length Protein Name
GI:31377521 GenBank AAF15395.1 400 growth factor-regulated G protein-coupled receptor Nrg-1 [Rattus norvegicus]
GI:31377521 GenBank ABT06636.1 400 Sequence 5 from patent US 7220580
GI:31377521 GenBank AEJ73528.1 400 Sequence 5 from patent US 7964358

Related Sequences to LMP012675 proteins

Reference Database Accession Length Protein Name
GI:31377521 GenBank AAF15395.1 400 growth factor-regulated G protein-coupled receptor Nrg-1 [Rattus norvegicus]
GI:31377521 GenBank ABT06636.1 400 Sequence 5 from patent US 7220580
GI:31377521 GenBank AEJ73528.1 400 Sequence 5 from patent US 7964358