Gene/Proteome Database (LMPD)

LMPD ID
LMP012824
Gene ID
85243
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene Symbol
Pik3cb
Alternate Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3K; PI3Kbeta; p110beta; PI3K-beta; ptdIns-3-kinase p110; PI3-kinase subunit beta; PI3-kinase p110 subunit beta; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; catalytic phosphatidylinositol 3-kinase beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform;
Chromosome
8
Map Location
8q31
EC Number
2.7.1.153
Summary
may play a role in hepatocyte proliferation and DNA replication [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pik3cb

Proteins

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Refseq ID NP_445933
Protein GI 16758236
UniProt ID Q9Z1L0
mRNA ID NM_053481
Length 1070
MCFRSIMPPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEHEPSVLENLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEEEASPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSSSLPLPLPPKKTRVISHVWGNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCRYMDSKMKPLWLVYSNRAFGEDAVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

Gene Information

Entrez Gene ID
85243
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene Symbol
Pik3cb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031526 IDA:RGD C brush border membrane
GO:0005829 TAS:Reactome C cytosol
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005942 IDA:RGD C phosphatidylinositol 3-kinase complex
GO:0016303 IDA:RGD F 1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:RefGenome F 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035004 NAS:RGD F phosphatidylinositol 3-kinase activity
GO:0046934 IBA:RefGenome F phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0006914 IEA:UniProtKB-KW P autophagy
GO:0007155 IEA:UniProtKB-KW P cell adhesion
GO:0006897 IEA:UniProtKB-KW P endocytosis
GO:0036092 IDA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0046854 IDA:RGD P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko04960 Aldosterone-regulated sodium reabsorption
rno04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko04210 Apoptosis
rno04210 Apoptosis
ko05100 Bacterial invasion of epithelial cells
rno05100 Bacterial invasion of epithelial cells
ko04662 B cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04973 Carbohydrate digestion and absorption
rno04973 Carbohydrate digestion and absorption
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko05210 Colorectal cancer
rno05210 Colorectal cancer
ko05213 Endometrial cancer
rno05213 Endometrial cancer
ko05169 Epstein-Barr virus infection
rno05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
rno04068 FoxO signaling pathway
ko05214 Glioma
rno05214 Glioma
rno05161 Hepatitis B
ko05160 Hepatitis C
rno05160 Hepatitis C
rno04066 HIF-1 signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko05164 Influenza A
rno05164 Influenza A
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko04670 Leukocyte transendothelial migration
rno04670 Leukocyte transendothelial migration
ko05162 Measles
rno05162 Measles
ko05218 Melanoma
rno05218 Melanoma
ko04150 mTOR signaling pathway
rno04150 mTOR signaling pathway
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko05212 Pancreatic cancer
rno05212 Pancreatic cancer
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
rno04611 Platelet activation
ko04914 Progesterone-mediated oocyte maturation
rno04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05215 Prostate cancer
rno05215 Prostate cancer
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton
ko05211 Renal cell carcinoma
rno05211 Renal cell carcinoma
ko04550 Signaling pathways regulating pluripotency of stem cells
rno04550 Signaling pathways regulating pluripotency of stem cells
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko04660 T cell receptor signaling pathway
rno04660 T cell receptor signaling pathway
rno04919 Thyroid hormone signaling pathway
ko04668 TNF signaling pathway
rno04668 TNF signaling pathway
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko04930 Type II diabetes mellitus
rno04930 Type II diabetes mellitus
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Protein Entry
PK3CB_RAT
UniProt ID
Q9Z1L0
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5- trisphosphate.
Domain The inhibitory interactions with PIK3R1 are mediated by the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1; the C2 PI3K-type domain, the PI3K helical domain, and the PI3K/PI4K kinase domain with the nSH2 (N- terminal SH2) region of PIK3R1; and the PI3K/PI4K kinase domain with the cSH2 (C-terminal SH2) region of PIK3R1. The inhibitory interaction between the PI3K-ABD domain and the C2 PI3K-type domain with the iSH2 (inter-SH2) region of PIK3R1 is weak. The nuclear localization signal (NLS) is required for its function in cell survival (By similarity)
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors (By similarity)
Pathway Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00877, ECO:0000255|PROSITE- ProRule:PRU00879, ECO:0000255|PROSITE-ProRule:PRU00880}.
Similarity Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 PI3K-ABD domain. {ECO:0000255|PROSITE- ProRule:PRU00877}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PI3K-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00879}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Cytoplasm . Nucleus . Note=Interaction with PIK3R2 is required for nuclear localization and export.
Subunit Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export (By similarity). Part of a complex with PIK3R1 and PTEN (By similarity). Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions (By similarity). Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4 (By similarity). Interacts with BECN1, ATG14 and RAB5A (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012824 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758236 RefSeq NP_445933 1070 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Identical Sequences to LMP012824 proteins

Reference Database Accession Length Protein Name
GI:16758236 EMBL CAA10046.1 1070 phosphatidylinositol 3-kinase, catalytic subunit, beta isoform [Rattus norvegicus]
GI:16758236 SwissProt Q9Z1L0.1 1070 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Short=PI3-kinase subunit beta; Short=PI3K-beta; Short=PI3Kbeta; Short=PtdIns-3-kinase subunit beta; AltName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Short=PtdIns-3-kinase subunit p110-beta; Short=p110beta [Rattus norvegicus]

Related Sequences to LMP012824 proteins

Reference Database Accession Length Protein Name
GI:16758236 EMBL CAA10046.1 1070 phosphatidylinositol 3-kinase, catalytic subunit, beta isoform [Rattus norvegicus]
GI:16758236 RefSeq XP_006243704.1 1070 PREDICTED: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [Rattus norvegicus]
GI:16758236 SwissProt Q9Z1L0.1 1070 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Short=PI3-kinase subunit beta; Short=PI3K-beta; Short=PI3Kbeta; Short=PtdIns-3-kinase subunit beta; AltName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Short=PtdIns-3-kinase subunit p110-beta; Short=p110beta [Rattus norvegicus]