Gene/Proteome Database (LMPD)

LMPD ID
LMP012887
Gene ID
116740
Species
Rattus norvegicus (Rat)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Gene Symbol
B3gnt5
Alternate Names
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; BGnT-5; beta3Gn-T5; lc3 synthase; beta-1,3-Gn-T5; lc(3)Cer synthase; lactotriaosylceramide synthase; beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-N-acetylglucosaminyltransferase-5; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5;
Chromosome
11
Map Location
11q23
EC Number
2.4.1.206

Proteins

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Refseq ID NP_446384
Protein GI 281306748
UniProt ID Q99NB2
mRNA ID NM_053932
Length 377
MRVFVSSRRVKRWQFFHLFAICFILSFMVFWGPINNYIMSHMKSYSYRYLINSYDFVNDSLSLKHSSVQPHHPYLINHREKCQAQDVLLLLFIKTAPENYERRSAIRKTWGNENYVQSQLNANIKILFALGTPHPLKGKELQKRLIWEDQVYHDIIQQDFTDSFHNLTFKFLLQFGWANTFCPHARFLMTADDDIFIHMPNLIEYLQGLEQVGVRDFWIGHVHRGGPPVRDKSSKYYVPYEMYKWPAYPDYTAGAAYVVSNDVAAKIYEASQTLNSSMYIDDVFMGLCANKVGVVPQDHVFFSGEGKIPYHPCIYEKMITSHGHSQDLQDLWVEATDPKVKDISKGFFGQIYCRLIKIVLLCRLTYRNSYPCRAAFA

Gene Information

Entrez Gene ID
116740
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Gene Symbol
B3gnt5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008457 IEA:Ensembl F beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
GO:0008378 IEA:InterPro F galactosyltransferase activity
GO:0047256 IEA:UniProtKB-EC F lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
GO:0008917 IEA:Ensembl F lipopolysaccharide N-acetylglucosaminyltransferase activity
GO:0007417 IEA:Ensembl P central nervous system development
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series
rno00601 Glycosphingolipid biosynthesis - lacto and neolacto series
M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer
M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953345 Metabolism of proteins
5954369 O-linked glycosylation
5954368 O-linked glycosylation of mucins
5953728 Post-translational protein modification

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Protein Entry
B3GN5_RAT
UniProt ID
Q99NB2
Species
Rat

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N- acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1)-ceramide.
Function Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development (By similarity)
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 31 family
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012887 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
281306748 RefSeq NP_446384 377 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

Identical Sequences to LMP012887 proteins

Reference Database Accession Length Protein Name
GI:281306748 GenBank EDL77982.1 377 rCG36757 [Rattus norvegicus]
GI:281306748 RefSeq XP_008767071.1 377 PREDICTED: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1 [Rattus norvegicus]
GI:281306748 SwissProt Q99NB2.2 377 RecName: Full=Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; AltName: Full=Lactotriaosylceramide synthase; Short=Lc(3)Cer synthase; Short=Lc3 synthase; AltName: Full=UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; Short=BGnT-5; Short=Beta-1,3-Gn-T5; Short=Beta-1,3-N-acetylglucosaminyltransferase 5; Short=Beta3Gn-T5 [Rattus norvegicus]

Related Sequences to LMP012887 proteins

Reference Database Accession Length Protein Name
GI:281306748 GenBank EDL77982.1 377 rCG36757 [Rattus norvegicus]
GI:281306748 RefSeq XP_008767071.1 377 PREDICTED: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1 [Rattus norvegicus]
GI:281306748 SwissProt Q99NB2.2 377 RecName: Full=Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; AltName: Full=Lactotriaosylceramide synthase; Short=Lc(3)Cer synthase; Short=Lc3 synthase; AltName: Full=UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; Short=BGnT-5; Short=Beta-1,3-Gn-T5; Short=Beta-1,3-N-acetylglucosaminyltransferase 5; Short=Beta3Gn-T5 [Rattus norvegicus]