Gene/Proteome Database (LMPD)

LMPD ID
LMP012901
Gene ID
117547
Species
Rattus norvegicus (Rat)
Gene Name
natural cytotoxicity triggering receptor 1
Gene Symbol
Ncr1
Synonyms
Ly94; Nkp46; KILR-1; Nk-p46;
Alternate Names
natural cytotoxicity triggering receptor 1; rAR-1; NKACTR; NK-p46); NK receptor KILR-1; activating receptor 1; rat-activating receptor 1; natural killer cell p46-related protein; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46);
Chromosome
1
Map Location
1q12
Summary
has similarity to immunoglobulins; expressed in NK cells [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ncr1

Proteins

natural cytotoxicity triggering receptor 1 precursor
Refseq ID NP_476547
Protein GI 17105354
UniProt ID Q9Z0H5
mRNA ID NM_057199
Length 325
MLPTLTALLCLGLCLSQRINTEKQTLPKPIIWAKPSIMVTKGNSVNIWCQGAQSASEYQLYFEGSFFALERPKSSRSMNKVKFFISQMTSHTAGIYTCFYQSGELWSESSNPLKLVVTGLYDTPTLWVHPGPEVTLGENVTFSCHLKTATSKFFLLKERESNHIQHKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGEVENTSLAPTDPVSSLDYWEFDLSTKESGLQKDSAFWDHTAQNLIRIGLACIIVMALVWLLAEDWLSRRKDHEKLNRLTSWECRGRRRMHRYHEEEQRDAISMRELKATPGDM
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1662 peptide sequence: MLPTLTALLCLGLCLS mat_peptide: 17..325 product: Natural cytotoxicity triggering receptor 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9Z0H5.1) calculated_mol_wt: 35535 peptide sequence: QRINTEKQTLPKPIIWAKPSIMVTKGNSVNIWCQGAQSASEYQLYFEGSFFALERPKSSRSMNKVKFFISQMTSHTAGIYTCFYQSGELWSESSNPLKLVVTGLYDTPTLWVHPGPEVTLGENVTFSCHLKTATSKFFLLKERESNHIQHKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGEVENTSLAPTDPVSSLDYWEFDLSTKESGLQKDSAFWDHTAQNLIRIGLACIIVMALVWLLAEDWLSRRKDHEKLNRLTSWECRGRRRMHRYHEEEQRDAISMRELKATPGDM

Gene Information

Entrez Gene ID
117547
Gene Name
natural cytotoxicity triggering receptor 1
Gene Symbol
Ncr1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane

KEGG Pathway Links

KEGG Pathway ID Description
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity

Domain Information

InterPro Annotations

Accession Description
IPR003599 Immunoglobulin subtype
IPR013783 Immunoglobulin-like fold

UniProt Annotations

Entry Information

Gene Name
natural cytotoxicity triggering receptor 1
Protein Entry
NCTR1_RAT
UniProt ID
Q9Z0H5
Species
Rat

Comments

Comment Type Description
Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis
Similarity Belongs to the natural cytotoxicity receptor (NCR) family
Similarity Contains 2 Ig-like (immunoglobulin-like) domains
Subcellular Location Cell membrane ; Single-pass type I membrane protein .
Subunit Interacts with CD3Z and FCER1G
Tissue Specificity Weakly expressed in spleen, heart and lung

Identical and Related Proteins

Unique RefSeq proteins for LMP012901 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17105354 RefSeq NP_476547 325 natural cytotoxicity triggering receptor 1 precursor

Identical Sequences to LMP012901 proteins

Reference Database Accession Length Protein Name
GI:17105354 EMBL CAA10161.1 325 NKactR [Rattus norvegicus]
GI:17105354 GenBank AAC69890.1 325 NK receptor KILR-1 [Rattus norvegicus]
GI:17105354 GenBank EDL75826.1 325 natural cytotoxicity triggering receptor 1 [Rattus norvegicus]
GI:17105354 SwissProt Q9Z0H5.1 325 RecName: Full=Natural cytotoxicity triggering receptor 1; AltName: Full=Activating receptor 1; Short=rAR-1; AltName: Full=Lymphocyte antigen 94 homolog; AltName: Full=NK receptor KILR-1; AltName: Full=NKACTR; AltName: Full=Natural killer cell p46-related protein; Short=NK-p46; Short=NKp46; AltName: CD_antigen=CD335; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012901 proteins

Reference Database Accession Length Protein Name
GI:17105354 GenBank AAC69890.1 325 NK receptor KILR-1 [Rattus norvegicus]
GI:17105354 GenBank EDL75826.1 325 natural cytotoxicity triggering receptor 1 [Rattus norvegicus]
GI:17105354 SwissProt Q9Z0H5.1 325 RecName: Full=Natural cytotoxicity triggering receptor 1; AltName: Full=Activating receptor 1; Short=rAR-1; AltName: Full=Lymphocyte antigen 94 homolog; AltName: Full=NK receptor KILR-1; AltName: Full=NKACTR; AltName: Full=Natural killer cell p46-related protein; Short=NK-p46; Short=NKp46; AltName: CD_antigen=CD335; Flags: Precursor [Rattus norvegicus]