Gene/Proteome Database (LMPD)

LMPD ID
LMP012948
Gene ID
171458
Species
Rattus norvegicus (Rat)
Gene Name
inositol polyphosphate multikinase
Gene Symbol
Ipmk
Synonyms
Impk; Ipk2;
Alternate Names
inositol polyphosphate multikinase; inositol polyphosphate kinase 2; inositol 1,3,4,6-tetrakisphosphate 5-kinase;
Chromosome
20
Map Location
20p11
EC Number
2.7.1.151
Summary
involved in the synthesis of inositol 1,4,5-trisphosphate and an inositol pyrophosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ipmk

Proteins

inositol polyphosphate multikinase
Refseq ID NP_599244
Protein GI 19705555
UniProt ID Q99NI4
mRNA ID NM_134417
Length 396
MAAEPPALRLRPPGSTGDSPPVPRLLGGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYTMVYAADCADAVLLELRKHLPKYYGVWSPPSAPNDVYLKLEDVTHKFNKPCIMDVKIGRKSYDPFASAEKIQQQVSKYPLMEEIGFLVLGMRVYHLHSDSYETQNQHYGRGLTKETLKEGVSKFFHNGFCLRKDAVAASIQKVEKILQWFENQKQLNFYASSLLFVYEGSSQPATTKSNDRTLAGRFLSKGALSDADVLECNNNFHLFSSPANGTSVGKSLSKAYSRHRKLYAKKHQSQTSLKVETLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPAGRQEIAEAEVRMIDFAHVFPSNTVDEGYVYGLKHLIAVLRSILDS

Gene Information

Entrez Gene ID
171458
Gene Name
inositol polyphosphate multikinase
Gene Symbol
Ipmk
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008440 IEA:Ensembl F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0000823 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 IEA:Ensembl F inositol tetrakisphosphate 3-kinase activity
GO:0032958 IEA:Ensembl P inositol phosphate biosynthetic process
GO:0001841 IEA:Ensembl P neural tube formation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954517 Synthesis of IPs in the nucleus

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate multikinase
Protein Entry
IPMK_RAT
UniProt ID
Q99NI4
Species
Rat

Comments

Comment Type Description
Catalytic Activity 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
Function Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity)
Similarity Belongs to the inositol phosphokinase (IPK) family
Subcellular Location Nucleus .
Tissue Specificity Highly expressed in kidney, and at lower levels in hippocampus, brain cortex, cerebellum, heart and lung

Identical and Related Proteins

Unique RefSeq proteins for LMP012948 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19705555 RefSeq NP_599244 396 inositol polyphosphate multikinase

Identical Sequences to LMP012948 proteins

Reference Database Accession Length Protein Name
GI:19705555 GenBank AAG42923.1 396 inositol polyphosphate multikinase [Rattus norvegicus]
GI:19705555 GenBank EDL97252.1 396 rCG60966, isoform CRA_b [Rattus norvegicus]
GI:19705555 SwissProt Q99NI4.1 396 RecName: Full=Inositol polyphosphate multikinase; AltName: Full=Inositol 1,3,4,6-tetrakisphosphate 5-kinase [Rattus norvegicus]

Related Sequences to LMP012948 proteins

Reference Database Accession Length Protein Name
GI:19705555 GenBank AAG42923.1 396 inositol polyphosphate multikinase [Rattus norvegicus]
GI:19705555 GenBank EDL97252.1 396 rCG60966, isoform CRA_b [Rattus norvegicus]
GI:19705555 RefSeq XP_006256407.1 397 PREDICTED: inositol polyphosphate multikinase isoform X1 [Rattus norvegicus]
GI:19705555 SwissProt Q99NI4.1 396 RecName: Full=Inositol polyphosphate multikinase; AltName: Full=Inositol 1,3,4,6-tetrakisphosphate 5-kinase [Rattus norvegicus]