Gene/Proteome Database (LMPD)

LMPD ID
LMP012962
Gene ID
192263
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class L
Gene Symbol
Pigl
Alternate Names
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; PIG-L; phosphatidylinositol glycan, class L; phosphatidylinositol-glycan biosynthesis class L protein;
Chromosome
10
Map Location
10q23
EC Number
3.5.1.89
Summary
catalyzes the N-deacetylation of N-acetyl-D-glucosaminylphosphatidylinositol in the second step of GPI anchor biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pigl

Proteins

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Refseq ID NP_620256
Protein GI 20302097
UniProt ID O35790
mRNA ID NM_138901
Length 252
MEVVGLLCVAVAVLTWGFLRVWNSAERMRSPEQAGLPGAGSRALVVIAHPDDEAMFFAPTILGLARLKQQVSLLCFSSGNYYNQGEIRKKELLQSCAVLGIPPSRVMIIDKREFPDDPEVQWDTEHVASTILQHIHANATDLVVTFDAEGVSGHSNHIALYKAVRALHSGGKLPEGCSVLTLQSVNVLRKYVFLLDLPWTLLSPQGVLFVLTSKEVAQAKKAMSCHRSQLLWFRHLYTVFSRYMSVNSLQLL

Gene Information

Entrez Gene ID
192263
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class L
Gene Symbol
Pigl
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042406 TAS:RGD C extrinsic component of endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000225 IMP:RGD F N-acetylglucosaminylphosphatidylinositol deacetylase activity
GO:0006506 IMP:RGD P GPI anchor biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00065 GPI-anchor biosynthesis, core oligosaccharide
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
rno00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953345 Metabolism of proteins
5953735 Post-translational modification: synthesis of GPI-anchored proteins
5953728 Post-translational protein modification
5953734 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related
IPR024078 Putative deacetylase LmbE-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class L
Protein Entry
PIGL_RAT
UniProt ID
O35790
Species
Rat

Comments

Comment Type Description
Catalytic Activity 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + acetate.
Function Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the PIGL family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012962 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20302097 RefSeq NP_620256 252 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Identical Sequences to LMP012962 proteins

Reference Database Accession Length Protein Name
GI:20302097 DBBJ BAA20869.1 252 PIG-L [Rattus norvegicus]
GI:20302097 GenBank AAH74020.1 252 Pigl protein [Rattus norvegicus]
GI:20302097 GenBank EDM04707.1 252 phosphatidylinositol glycan, class L [Rattus norvegicus]
GI:20302097 SwissProt O35790.1 252 RecName: Full=N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; AltName: Full=Phosphatidylinositol-glycan biosynthesis class L protein; Short=PIG-L [Rattus norvegicus]

Related Sequences to LMP012962 proteins

Reference Database Accession Length Protein Name
GI:20302097 DBBJ BAA20869.1 252 PIG-L [Rattus norvegicus]
GI:20302097 GenBank AAH74020.1 252 Pigl protein [Rattus norvegicus]
GI:20302097 GenBank EDM04707.1 252 phosphatidylinositol glycan, class L [Rattus norvegicus]
GI:20302097 SwissProt O35790.1 252 RecName: Full=N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; AltName: Full=Phosphatidylinositol-glycan biosynthesis class L protein; Short=PIG-L [Rattus norvegicus]