Gene/Proteome Database (LMPD)

LMPD ID
LMP012966
Gene ID
245960
Species
Rattus norvegicus (Rat)
Gene Name
ALG10, alpha-1,2-glucosyltransferase
Gene Symbol
Alg10
Synonyms
KCR1; Alg10b;
Alternate Names
putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; potassium channel regulator 1; alpha-2-glucosyltransferase ALG10-B; alpha-1,2-glucosyltransferase ALG10-A; putative alpha-1,2-glucosyltransferase ALG10-B; asparagine-linked glycosylation protein 10 homolog B; asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B; asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase);
Chromosome
7
Map Location
7q34
EC Number
2.4.1.256
Summary
regulatory component of non-inactivating K+ channels [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Alg10

Proteins

putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Refseq ID NP_620801
Protein GI 20806143
UniProt ID O88788
mRNA ID NM_139101
Length 474
MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGRFSLSQWDPMITTLPGLYLVSVGVVKPASWILGWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFRKIQPRNKASSSIQRILSTLTLAVFPTLYFFNFLYYTEAGSVFFTLFAYLMCLYGNHRTSALLGFCGFMFRQTNIIWAAFCAGHIIAQKCSEAWKTELQKKKEERLPPAKGPLSELRRVLQFLLMYSMSLKNLSMLFLLTWPYMLLLLAFFVFVVVNGGIVVGDRSSHEACLHFPQLFYFFSFTAFFSFPHLLSPTKVKTFLSLVWKRRVQFSVITLVSVFLVWKFTYVHKYLLADNRHYTFYVWKRVFQRHEIVKYLLVPAYMFAGWAVADSLKSKSIFWNLMFFVCLVASTVPQKLLEFRYFILPYIIYRLNMPLPPISRLVCELGCYAVVNFLTFYIFLNKTFQWSDSHDIQRFMW

Gene Information

Entrez Gene ID
245960
Gene Name
ALG10, alpha-1,2-glucosyltransferase
Gene Symbol
Alg10
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0015459 IMP:RGD F potassium channel regulator activity
GO:0016758 IEA:InterPro F transferase activity, transferring hexosyl groups

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00510 N-Glycan biosynthesis
rno00510 N-Glycan biosynthesis
M00055 N-glycan precursor biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953739 Asparagine N-linked glycosylation
5953738 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5953345 Metabolism of proteins
5953728 Post-translational protein modification

Domain Information

InterPro Annotations

Accession Description
IPR016900 Alg10

UniProt Annotations

Entry Information

Gene Name
ALG10, alpha-1,2-glucosyltransferase
Protein Entry
AG10B_RAT
UniProt ID
O88788
Species
Rat

Comments

Comment Type Description
Catalytic Activity Dolichyl beta-D-glucosyl phosphate + D-Glc- alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)- (D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man- beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D- Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))- D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D- GlcNAc-diphosphodolichol + dolichyl phosphate.
Function Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2
Similarity Belongs to the ALG10 glucosyltransferase family
Subcellular Location Cell membrane ; Multi-pass membrane protein .
Subunit Interacts with KCNH1 and KCNH2
Tissue Specificity Highly expressed in brain, skeletal muscle, uterus, small intestine and liver. Moderately expressed in lung and kidney. Weakly expressed in heart and stomach

Identical and Related Proteins

Unique RefSeq proteins for LMP012966 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20806143 RefSeq NP_620801 474 putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Identical Sequences to LMP012966 proteins

Reference Database Accession Length Protein Name
GI:20806143 GenBank AAC34249.1 474 potassium channel regulator 1 [Rattus norvegicus]
GI:20806143 GenBank ABH82374.1 474 Sequence 95 from patent US 7045509
GI:20806143 GenBank EDL76589.1 474 rCG59318, isoform CRA_b [Rattus norvegicus]
GI:20806143 SwissProt O88788.1 474 RecName: Full=Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; AltName: Full=Alpha-1,2-glucosyltransferase ALG10-A; AltName: Full=Alpha-2-glucosyltransferase ALG10-B; AltName: Full=Asparagine-linked glycosylation protein 10 homolog B; AltName: Full=Potassium channel regulator 1 [Rattus norvegicus]

Related Sequences to LMP012966 proteins

Reference Database Accession Length Protein Name
GI:20806143 GenBank AAC34249.1 474 potassium channel regulator 1 [Rattus norvegicus]
GI:20806143 GenBank ABH82374.1 474 Sequence 95 from patent US 7045509
GI:20806143 GenBank EDL76589.1 474 rCG59318, isoform CRA_b [Rattus norvegicus]
GI:20806143 SwissProt O88788.1 474 RecName: Full=Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; AltName: Full=Alpha-1,2-glucosyltransferase ALG10-A; AltName: Full=Alpha-2-glucosyltransferase ALG10-B; AltName: Full=Asparagine-linked glycosylation protein 10 homolog B; AltName: Full=Potassium channel regulator 1 [Rattus norvegicus]