Gene/Proteome Database (LMPD)

LMPD ID
LMP013092
Gene ID
292661
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin I2 (prostacyclin) receptor (IP)
Gene Symbol
Ptgir
Alternate Names
prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor; prostaglandin I receptor (IP);
Chromosome
1
Map Location
1q21

Proteins

prostacyclin receptor
Refseq ID NP_001071112
Protein GI 117647216
UniProt ID P43253
mRNA ID NM_001077644
Length 416
MVASGGRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSPQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLCHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTGIMAVCSLPLTIRGFTQAIAPDSREMGDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQTPLSRPVSGRRDTLAPDSLQAKEGNWVPLSTWGTGQVAPLTAVPLSGGDGCSVGMPSKTEAVVACSLC
mat_peptide: 1..413 product: Prostacyclin receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P43253.1) calculated_mol_wt: 44359 peptide sequence: MVASGGRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSPQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLCHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTGIMAVCSLPLTIRGFTQAIAPDSREMGDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQTPLSRPVSGRRDTLAPDSLQAKEGNWVPLSTWGTGQVAPLTAVPLSGGDGCSVGMPSKTEAVVAC

Gene Information

Entrez Gene ID
292661
Gene Name
prostaglandin I2 (prostacyclin) receptor (IP)
Gene Symbol
Ptgir
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 IEA:UniProtKB-KW F G-protein coupled receptor activity
GO:0007189 IEA:Ensembl P adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0010642 IEA:Ensembl P negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0048662 IEA:Ensembl P negative regulation of smooth muscle cell proliferation
GO:0030819 IEA:Ensembl P positive regulation of cAMP biosynthetic process
GO:0043950 IEA:Ensembl P positive regulation of cAMP-mediated signaling
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
rno04611 Platelet activation
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953755 G alpha (s) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953645 Hemostasis
5953658 Platelet homeostasis
5954209 Prostacyclin signalling through prostacyclin receptor
5954201 Prostanoid ligand receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000370 Prostacyclin (prostanoid IP) receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin I2 (prostacyclin) receptor (IP)
Protein Entry
PI2R_RAT
UniProt ID
P43253
Species
Rat

Comments

Comment Type Description
Function Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Ptm Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts (non-isoprenylated C-terminus) with PDZK1

Identical and Related Proteins

Unique RefSeq proteins for LMP013092 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
117647216 RefSeq NP_001071112 416 prostacyclin receptor

Identical Sequences to LMP013092 proteins

Reference Database Accession Length Protein Name
GI:117647216 DBBJ BAA06091.1 416 prostacyclin receptor [Rattus sp.]
GI:117647216 GenBank EDM08295.1 416 prostaglandin I receptor (IP) (predicted), isoform CRA_b [Rattus norvegicus]
GI:117647216 SwissProt P43253.1 416 RecName: Full=Prostacyclin receptor; AltName: Full=Prostaglandin I2 receptor; Short=PGI receptor; Short=PGI2 receptor; AltName: Full=Prostanoid IP receptor; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013092 proteins

Reference Database Accession Length Protein Name
GI:117647216 DBBJ BAA06091.1 416 prostacyclin receptor [Rattus sp.]
GI:117647216 GenBank EDM08295.1 416 prostaglandin I receptor (IP) (predicted), isoform CRA_b [Rattus norvegicus]
GI:117647216 PRF - 413 prostacyclin receptor [Rattus norvegicus]
GI:117647216 SwissProt P43253.1 416 RecName: Full=Prostacyclin receptor; AltName: Full=Prostaglandin I2 receptor; Short=PGI receptor; Short=PGI2 receptor; AltName: Full=Prostanoid IP receptor; Flags: Precursor [Rattus norvegicus]