Gene/Proteome Database (LMPD)

LMPD ID
LMP013104
Gene ID
293620
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylserine synthase 2
Gene Symbol
Ptdss2
Synonyms
PSS-2;
Alternate Names
phosphatidylserine synthase 2; ptdSer synthase 2; serine-exchange enzyme II;
Chromosome
1
Map Location
1q41
EC Number
2.7.8.29

Proteins

phosphatidylserine synthase 2
Refseq ID NP_001099786
Protein GI 157821375
UniProt ID B2GV22
mRNA ID NM_001106316
Length 471
MRRGERRVAGGSGSESPLLEGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCALGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVHDGRQFLKYVDPRLGVPLPERDYGGNCLIYDADNKTDPFHNIWDKLDGFVPAHFIGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLLCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSWVRFEWKPASSLHRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDELKPHRKLGQQAWLVAAITVTELLIVVKYDPHTLTLSLPFYISQCWTLGSILVLTWTVWRFFLRDITMRYKETRRQKQQSHQAINNGDGHPGPEDDLPGTGTAEEEGTTNDGVPAEEGPSAAS

Gene Information

Entrez Gene ID
293620
Gene Name
phosphatidylserine synthase 2
Gene Symbol
Ptdss2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003882 IEA:Ensembl F CDP-diacylglycerol-serine O-phosphatidyltransferase activity
GO:0006659 IEA:UniProtKB-UniPathway P phosphatidylserine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954479 Synthesis of PS

Domain Information

InterPro Annotations

Accession Description
IPR004277 Phosphatidyl serine synthase

UniProt Annotations

Entry Information

Gene Name
phosphatidylserine synthase 2
Protein Entry
PTSS2_RAT
UniProt ID
B2GV22
Species
Rat

Comments

Comment Type Description
Catalytic Activity L-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
Function Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity)
Pathway Phospholipid metabolism; phosphatidylserine biosynthesis.
Similarity Belongs to the phosphatidyl serine synthase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Note=Highly enriched in the mitochondria-associated membrane (MAM)

Identical and Related Proteins

Unique RefSeq proteins for LMP013104 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157821375 RefSeq NP_001099786 471 phosphatidylserine synthase 2

Identical Sequences to LMP013104 proteins

Reference Database Accession Length Protein Name
GI:157821375 GenBank EDM11981.1 471 phosphatidylserine synthase 2 (predicted), isoform CRA_d [Rattus norvegicus]
GI:157821375 GenBank AAI66496.1 471 Phosphatidylserine synthase 2 [Rattus norvegicus]
GI:157821375 SwissProt B2GV22.1 471 RecName: Full=Phosphatidylserine synthase 2; Short=PSS-2; Short=PtdSer synthase 2; AltName: Full=Serine-exchange enzyme II [Rattus norvegicus]

Related Sequences to LMP013104 proteins

Reference Database Accession Length Protein Name
GI:157821375 GenBank AAH53517.1 473 Phosphatidylserine synthase 2 [Mus musculus]
GI:157821375 GenBank EDM11981.1 471 phosphatidylserine synthase 2 (predicted), isoform CRA_d [Rattus norvegicus]
GI:157821375 GenBank AAI66496.1 471 Phosphatidylserine synthase 2 [Rattus norvegicus]
GI:157821375 SwissProt B2GV22.1 471 RecName: Full=Phosphatidylserine synthase 2; Short=PSS-2; Short=PtdSer synthase 2; AltName: Full=Serine-exchange enzyme II [Rattus norvegicus]