Gene/Proteome Database (LMPD)

LMPD ID
LMP013345
Gene ID
312086
Species
Rattus norvegicus (Rat)
Gene Name
paraoxonase 3
Gene Symbol
Pon3
Alternate Names
serum paraoxonase/lactonase 3;
Chromosome
4
Map Location
4q13
EC Number
3.1.1.2
Summary
microsomal paraoxonase that has esterase activity on a broad range of substrates [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pon3

Proteins

serum paraoxonase/lactonase 3 precursor
Refseq ID NP_001004086
Protein GI 51854237
UniProt ID Q68FP2
mRNA ID NM_001004086
Length 354
MGKLVALTVLGASLALLGERLLNFRERVSTSREIKPTEPQNCHLIEGLENGSEDIDILPSGLAFISTGLKYPGMPSFAPDKPGRIFLMDLNEPYPKAQALEISDGFDQDSLNPHGISTFIDKDNTVYLYAVNHPHMDSTVEIFKFEEQPRSLVHLKTIKHELFESVNDIVVLGPEQFYATRDHYFTSHFLVLLEMILDPHWTSVLFYSPKEVKVVAQGFSSANGITVSLDQKYVYVADVTAKNIHIMKKHNNWDLTPVKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLIYNPEDPPGSEVLRIQDPLSDNPRVSTLYSNNGSVLQGSTVASVYHKKMLIGTIFHKALYCEL
sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1444 peptide sequence: MGKLVALTVLGASLA

Gene Information

Entrez Gene ID
312086
Gene Name
paraoxonase 3
Gene Symbol
Pon3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IMP:RGD C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0018733 IDA:RGD F 3,4-dihydrocoumarin hydrolase activity
GO:0004063 IEA:UniProtKB-EC F aryldialkylphosphatase activity
GO:0004064 IDA:RGD F arylesterase activity
GO:0047856 IDA:RGD F dihydrocoumarin hydrolase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046226 IDA:RGD P coumarin catabolic process
GO:0010124 IDA:RGD P phenylacetate catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002640 Arylesterase
IPR008364 Paraoxonase2
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
paraoxonase 3
Protein Entry
PON3_RAT
UniProt ID
Q68FP2
Species
Rat

Comments

Comment Type Description
Catalytic Activity A phenyl acetate + H(2)O = a phenol + acetate.
Catalytic Activity An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine.
Catalytic Activity An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 2 calcium ions per subunit. ;
Function Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity)
Ptm Glycosylated
Ptm The signal sequence is not cleaved
Similarity Belongs to the paraoxonase family
Subcellular Location Secreted, extracellular space .
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP013345 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51854237 RefSeq NP_001004086 354 serum paraoxonase/lactonase 3 precursor

Identical Sequences to LMP013345 proteins

Reference Database Accession Length Protein Name
GI:51854237 GenBank AAH79466.1 354 Paraoxonase 3 [Rattus norvegicus]
GI:51854237 GenBank EDM15021.1 354 paraoxonase 3, isoform CRA_b [Rattus norvegicus]
GI:51854237 SwissProt Q68FP2.1 354 RecName: Full=Serum paraoxonase/lactonase 3 [Rattus norvegicus]

Related Sequences to LMP013345 proteins

Reference Database Accession Length Protein Name
GI:51854237 GenBank AAH79466.1 354 Paraoxonase 3 [Rattus norvegicus]
GI:51854237 GenBank EDM15021.1 354 paraoxonase 3, isoform CRA_b [Rattus norvegicus]
GI:51854237 GenBank ADL98070.1 354 Sequence 11 from patent US 7718773
GI:51854237 SwissProt Q68FP2.1 354 RecName: Full=Serum paraoxonase/lactonase 3 [Rattus norvegicus]