Gene/Proteome Database (LMPD)

LMPD ID
LMP013347
Gene ID
312495
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol
Cyp26b1
Alternate Names
cytochrome P450 26B1;
Chromosome
4
Map Location
4q34
EC Number
1.14.-.-;
Summary
human homolog is a monooxygenase that catalyzes the inactivation of all-trans-retinoic acid to hydroxylated forms [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp26b1

Proteins

cytochrome P450 26B1
Refseq ID NP_851601
Protein GI 30842834
UniProt ID G3V7X8
mRNA ID NM_181087
Length 512
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGNLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAVREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

Gene Information

Entrez Gene ID
312495
Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Gene Symbol
Cyp26b1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008401 IMP:RGD F retinoic acid 4-hydroxylase activity
GO:0001972 IEA:Ensembl F retinoic acid binding
GO:0060349 IEA:Ensembl P bone morphogenesis
GO:0001709 IEA:Ensembl P cell fate determination
GO:0071300 IEA:Ensembl P cellular response to retinoic acid
GO:0070268 IEA:Ensembl P cornification
GO:0030326 IEA:Ensembl P embryonic limb morphogenesis
GO:0061436 IEA:Ensembl P establishment of skin barrier
GO:0007140 IEA:Ensembl P male meiosis
GO:0048387 IEA:Ensembl P negative regulation of retinoic acid receptor signaling pathway
GO:0010628 IEA:Ensembl P positive regulation of gene expression
GO:2001037 IEA:Ensembl P positive regulation of tongue muscle cell differentiation
GO:0009954 IEA:Ensembl P proximal/distal pattern formation
GO:0034653 IMP:RGD P retinoic acid catabolic process
GO:0042573 IEP:RGD P retinoic acid metabolic process
GO:0048384 IEA:Ensembl P retinoic acid receptor signaling pathway
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0043587 IEA:Ensembl P tongue morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00830 Retinol metabolism
rno00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953258 Biological oxidations
5953485 Cytochrome P450 - arranged by substrate type
5953250 Metabolism
5953326 Phase 1 - Functionalization of compounds
5954061 Vitamins

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 26, subfamily b, polypeptide 1
Protein Entry
CP26B_RAT
UniProt ID
G3V7X8
Species
Rat

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity)
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013347 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30842834 RefSeq NP_851601 512 cytochrome P450 26B1

Identical Sequences to LMP013347 proteins

Reference Database Accession Length Protein Name
GI:30842834 GenBank AAO92253.1 512 cytochrome P450RAI-2 [Rattus norvegicus]

Related Sequences to LMP013347 proteins

Reference Database Accession Length Protein Name
GI:30842834 DBBJ BAE23242.1 512 unnamed protein product [Mus musculus]
GI:30842834 GenBank AAO92253.1 512 cytochrome P450RAI-2 [Rattus norvegicus]
GI:30842834 GenBank EDL91177.1 512 cytochrome P450, family 26, subfamily b, polypeptide 1 [Rattus norvegicus]
GI:30842834 SwissProt G3V7X8.1 512 RecName: Full=Cytochrome P450 26B1 [Rattus norvegicus]