Gene/Proteome Database (LMPD)

LMPD ID
LMP013415
Gene ID
359725
Species
Rattus norvegicus (Rat)
Gene Name
carbonyl reductase 4
Gene Symbol
Cbr4
Alternate Names
carbonyl reductase family member 4; carbonic reductase 4; quinone reductase CBR4; 3-oxoacyl-[acyl-carrier-protein] reductase;
Chromosome
16
Map Location
16p12
EC Number
1.-.-.-

Proteins

carbonyl reductase family member 4
Refseq ID NP_872613
Protein GI 32996723
UniProt ID Q7TS56
mRNA ID NM_182672
Length 236
MDKVCAVFGGSRGIGKAVAQLMAQKGYRLAIVARNLEVAKATASELGGIHLAFRCNIAKEGDVHSTFEEMEKHLGPVNFLVNAAGINRDSLLVRTKTEDMLSQLHTNLLGTMLTCRAAMRTMIQQGGSIVNVGSIIGLKGNVGQAAYSATKGGLIGFSRSLAKEVARKKIRVNVVAPGFIHTDMTKHLKEEHFKKNIPLGRFGEALEVAHAVVFLLESPYITGHVLIVDGGLQLTA

Gene Information

Entrez Gene ID
359725
Gene Name
carbonyl reductase 4
Gene Symbol
Cbr4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 ISS:UniProtKB C mitochondrial matrix
GO:0070402 ISS:UniProtKB F NADPH binding
GO:0008753 ISS:UniProtKB F NADPH dehydrogenase (quinone) activity
GO:0048038 ISS:UniProtKB F quinone binding
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
carbonyl reductase 4
Protein Entry
CBR4_RAT
UniProt ID
Q7TS56
Species
Rat

Comments

Comment Type Description
Function The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity)
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Mitochondrion matrix .
Subunit Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013415 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32996723 RefSeq NP_872613 236 carbonyl reductase family member 4

Identical Sequences to LMP013415 proteins

Reference Database Accession Length Protein Name
GI:32996723 EMBL CBF61552.1 236 unnamed protein product [Rattus norvegicus]
GI:32996723 EMBL CBU86504.1 236 unnamed protein product [Rattus norvegicus]
GI:32996723 GenBank EDL87203.1 236 carbonic reductase 4, isoform CRA_a [Rattus norvegicus]
GI:32996723 GenBank AGX53389.1 236 Sequence 7147 from patent US 8541208

Related Sequences to LMP013415 proteins

Reference Database Accession Length Protein Name
GI:32996723 EMBL CBF61552.1 236 unnamed protein product [Rattus norvegicus]
GI:32996723 EMBL CBU86504.1 236 unnamed protein product [Rattus norvegicus]
GI:32996723 GenBank AGX53389.1 236 Sequence 7147 from patent US 8541208
GI:32996723 SwissProt Q7TS56.1 236 RecName: Full=Carbonyl reductase family member 4; AltName: Full=3-oxoacyl-[acyl-carrier-protein] reductase; AltName: Full=Quinone reductase CBR4 [Rattus norvegicus]