Gene/Proteome Database (LMPD)

LMPD ID
LMP013536
Gene ID
366196
Species
Rattus norvegicus (Rat)
Gene Name
cardiolipin synthase 1
Gene Symbol
Crls1
Synonyms
RGD1311037;
Alternate Names
cardiolipin synthase; CLS; cardiolipin synthetase;
Chromosome
3
Map Location
3q36
EC Number
2.7.8.-;

Proteins

cardiolipin synthase
Refseq ID NP_001014280
Protein GI 62079247
UniProt ID Q5U2V5
mRNA ID NM_001014258
Length 302
MLAWRVARGAWGSLRVAVRPPGARLGRGGSRRALLPPAACCLGCLAERWRLRPAAFALRLPGTSPRTHCSGAGKAAPEPAAGGDAAAQAPSARWVRASATSSYENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWANQKSALGSALDPLADKVLISILYISLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCCTAFTTAASAYSYYHYGRKTVQVIKGK

Gene Information

Entrez Gene ID
366196
Gene Name
cardiolipin synthase 1
Gene Symbol
Crls1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0016780 IEA:InterPro F phosphotransferase activity, for other substituted phosphate groups
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5954465 Acyl chain remodelling of PG
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954476 Synthesis of CL

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase

UniProt Annotations

Entry Information

Gene Name
cardiolipin synthase 1
Protein Entry
CRLS1_RAT
UniProt ID
Q5U2V5
Species
Rat

Comments

Comment Type Description
Catalytic Activity 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.
Function Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Subcellular Location Mitochondrion inner membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013536 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62079247 RefSeq NP_001014280 302 cardiolipin synthase

Identical Sequences to LMP013536 proteins

Reference Database Accession Length Protein Name
GI:62079247 GenBank AAH85849.1 302 Cardiolipin synthase 1 [Rattus norvegicus]
GI:62079247 GenBank EDL80276.1 302 similar to chromosome 20 open reading frame 155 [Rattus norvegicus]
GI:62079247 SwissProt Q5U2V5.1 302 RecName: Full=Cardiolipin synthase; Short=CLS [Rattus norvegicus]

Related Sequences to LMP013536 proteins

Reference Database Accession Length Protein Name
GI:62079247 GenBank AAH85849.1 302 Cardiolipin synthase 1 [Rattus norvegicus]
GI:62079247 GenBank EDL80276.1 302 similar to chromosome 20 open reading frame 155 [Rattus norvegicus]
GI:62079247 RefSeq NP_001019556.1 303 cardiolipin synthase isoform 1 [Mus musculus]
GI:62079247 SwissProt Q5U2V5.1 302 RecName: Full=Cardiolipin synthase; Short=CLS [Rattus norvegicus]